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  4. Recombinant Human Heterogeneous nuclear ribonucleoprotein L-like (HNRPLL)

Recombinant Human Heterogeneous nuclear ribonucleoprotein L-like (HNRPLL)

  • 货号：
    CSB-YP010630HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP010630HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP010630HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010630HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010630HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HNRNPLL
  • Uniprot No.：
  • 别名：
    BLOCK24; Heterogeneous nuclear ribonucleoprotein L like; Heterogeneous nuclear ribonucleoprotein L-like; HNRLL_HUMAN; hnRNPLL; HNRPLL; SRRF; Stromal RNA regulating factor ; Stromal RNA-regulating factor
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-542
  • 氨基酸序列
    MSSSSSSPRE TYEEDREYES QAKRLKTEEG EIDYSAEEGE NRREATPRGG GDGGGGGRSF SQPEAGGSHH KVSVSPVVHV RGLCESVVEA DLVEALEKFG TICYVMMMPF KRQALVEFEN IDSAKECVTF AADEPVYIAG QQAFFNYSTS KRITRPGNTD DPSGGNKVLL LSIQNPLYPI TVDVLYTVCN PVGKVQRIVI FKRNGIQAMV EFESVLCAQK AKAALNGADI YAGCCTLKIE YARPTRLNVI RNDNDSWDYT KPYLGRRDRG KGRQRQAILG EHPSSFRHDG YGSHGPLLPL PSRYRMGSRD TPELVAYPLP QASSSYMHGG NPSGSVVMVS GLHQLKMNCS RVFNLFCLYG NIEKVKFMKT IPGTALVEMG DEYAVERAVT HLNNVKLFGK RLNVCVSKQH SVVPSQIFEL EDGTSSYKDF AMSKNNRFTS AGQASKNIIQ PPSCVLHYYN VPLCVTEETF TKLCNDHEVL TFIKYKVFDA KPSAKTLSGL LEWECKTDAV EALTALNHYQ IRVPNGSNPY TLKLCFSTSS HL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
  • 基因功能参考文献：
    1. Loss-of-function mutation of hnRNPLL disrupts peripheral T cell accumulation even in the absence of CD45 protein, indicating that hnRNPLL acts through an independent mechanism to promote peripheral T cell longevity. PMID: 20505149
    2. Participation of SRRF (Stromal RNA Regulating Factor) isoforms in post-transcriptional events in bone marrow stromal cells; an important role in regulation of the RNA expression that directs the bone marrow stromal cells differentiation pathway PMID: 15256261
    3. identification of heterogeneous ribonucleoprotein L-like (hnRNPLL) as a critical inducible regulator of CD45 alternative splicing PMID: 18669861
    4. These data establish that hnRNP LL plays a critical and unique role in the signal-induced regulation of CD45 and demonstrate the utility of cell-based screens for the identification of novel splicing regulatory factors. PMID: 18719244
  • 组织特异性：
    Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung.
  • 数据库链接：

    HGNC: 25127

    OMIM: 611208

    KEGG: hsa:92906

    STRING: 9606.ENSP00000387088

    UniGene: Hs.445497