Recombinant Human Glutathione S-transferase Mu 1 (GSTM1)

1. Patients having Glutathione S-transferase M1 allele and Apolipoprotein E E2 allele are predisposed to oxidative stress-induced cardiac injury. PMID: 30095041
2. The 6-TGN levels were not affected by the GSTM1 genotype. PMID: 28045129
3. Complex Haplotypes of GSTM1 Gene Deletions Harbor Signatures of a Selective Sweep in East Asian Populations. PMID: 30061374
4. These results illustrate the potential association between rs9642880 G > T and survival in hepatocellular carcinoma patients who received radiotherapy treatment. PMID: 29396413
5. GSTM1 and GSTT1 gene polymorphisms are not associated with lipid levels in endogenous hypertriglyceridemia in Chinese population. PMID: 29896743
6. This study suggests that GSTM1 active and GSTT1 null genotype combination might be a risk factor in developing mitochondrial disease. PMID: 29235020
7. The meta-analysis showed that glutathione S-transferases GSTT1 and GSTM1 null polymorphisms are risk factors for breast cancer [Meta-analysis]. PMID: 29932073
8. individuals carrying GSTM1 null variant showed protective role against seizure. PMID: 30179425
9. Our meta-analysis supports that CYP1A1 exon7 polymorphism might contribute to individual susceptibility to esophageal cancer in the Chinese population. Gene-gene interaction analysis found a synergistic interaction between CYP1A1 mutation genotypes and GSTM1 deletion genotype. PMID: 28164573
10. The effects of GSTM1/GSTT1 genes on diabetes mellitus type 2 risk are gender dependent and may be triggered by tobacco smoking. PMID: 29111615
11. GSTM1 gene polymorphism is associated with liver diseases. PMID: 29582627
12. this is the first report on the GSTM1and GSTT1frequency distribution among the tribal population of western India. PMID: 29666321
13. s conclude that maternal GSTM1/GSTT1 gene polymorphisms present an impact on birth weight, being involved in the neonatal nutritional status. PMID: 29556619
14. VEGF, VEGFR2 and GSTM1 polymorphisms in outcome of multiple myeloma patients treated with thalidomide-based regimens PMID: 28665417
15. Based on our meta-analysis, the GSTM1 null genotype is a risk factor for CRC. PMID: 29516983
16. Indel variants of GSTM1 were typed in breast cancer patients and normal controls. GSTM1 deletion seemed to marginally increase breast cancer risk in Mexican women. PMID: 29267651
17. The current analyses suggests significant association was found between GSTM1 variants and the risk of childhood acute lymphoblastic leukemia (ALL), while no association were found between GSTT1 and GSTP1 Ile105Val polymorphism and childhood ALL risk PMID: 28176509
18. In conclusion, the present study indicated that GSTT1 deletion was associated with increased recurrence risk of breast cancer, while GSTM1 correlated with worst prognosis parameters at diagnosis, but was negatively associated with recurrence risk in luminal subtype samples. PMID: 28455582
19. Homozygous deletion of GSTM1 is associated with slower HIV disease progression. PMID: 29795558
20. The patients homozygous for the GSTM1 null alleles showed a 3.5 increased risk of Alzheimer's disease PMID: 29072550
21. Our findings suggest that the GSTM1 (-) allele may be considered as a key factor for the development of carbamazepine-induced hepatotoxicity PMID: 29523098
22. We observed an association between GSTM1 and Stevens Johnson Syndrome Toxic Epidermal Necrolysis. PMID: 28689274
23. Using PCR, analyzed copy number variations in glutathione S-transferase M1 (GSTM1) gene and determined their genetic contribution in Tunisian rheumatoid arthritis (RA). PMID: 28703442
24. GSTM1 showed a significant association with several GV, arterial stiffness, and SV balance indexes. In particular, the GSTM1 deletion positively correlates with lower values of these indexes when compared to the presence of the gene. PMID: 29452132
25. Individuals with ASD (autism spectrum disorder)showed a significant diminished level of reduced glutathione, however, the distribution of GSTT1, GSTM1, and GSTP1 polymorphisms was not found to be associated with autism in this study population. PMID: 29072241
26. GSTM1 and GSTT1 gene polymorphisms are closely correlated with the pathogenesis of COPD. PMID: 28951769
27. Analyses of the GSTM1 polymorphisms demonstrated that there was a significantly increased Esophageal Carcinoma risk in GSTM1 null genotype carriers (OR = 1.319, 95% CI = 1.125-1.546, p for heterogeneity <0.001).In the GSTM1-GSTT1 interaction analysis, we discovered remarkably enhanced EC risk for patients with the GSTM1 and GSTT1 dual null genotypes (OR = 1.962, 95% CI = 1.178-3.268, p for heterogeneity <0.001) PMID: 29215312
28. The findings indicate that GSTM1 may be a causal gene of both anti-tuberculosis drug-induced hepatotoxicity and schizophrenia. (Meta-analysis) PMID: 27580934
29. findings indicated that GSTM1 polymorphism might affect the association between exposure to perfluorinated compounds (PFCs) and birth weight, suggesting the effect of genetic susceptibility on the relationship between prenatal PFCs exposure and birth outcomes PMID: 27206125
30. This study showed a significant trend towards an association with the combination of the GSTM1/GSTT1 double null polymorphism and generalized vitiligo. Individuals with GSTM1 null/GSTT1+ heterozygosis have a 2.97 odds protection from having generalized vitiligo compared with patients. PMID: 29641697
31. The findings are consistent with the notion that the frequency of homozygous carriers of the GSTM1(0/0)/GSTT1(0/0) genotype is increased among males with reproductive problems. PMID: 28744640
32. The neonates who had GSTT1 or GSTM1 polymorphism were associated with an increased risk of being small for gestational age SGA. A combination of the GSTT1 and GSTM1 null genotype exacerbated the effect of maternal environmental tobacco smoke exposure on SGA more than the presence of either genotype alone (odds ratio=8.90, 95% confidence interval=1.00-79.5). PMID: 28216421
33. GSTT1 and GSTM1 may modulate DNA damage levels of p53 gene when exposed to polycyclic aromatic hydrocarbons. PMID: 28426525
34. Carriers of GSTM1-null and GSTP1-variant genotypes are in increased risk of RCC development. On the contrary, GSTM1-null genotype is associated with favorable postoperative prognosis in ccRCC. PMID: 28284893
35. Suggest that the donors and recipients' GSTM1 polymorphism may be a major risk factor for oxidative stress and delayed graft function in kidney transplant recipients. PMID: 28575886
36. The combination of glutathione S-transferase theta 1 (GST T1) null/glutathione S-transferase mu 1 (GST M1) wild genotype was significantly more frequent in diabetic patients than controls, indicating a significantly increased risk of type 1 diabetes mellitus (T1DM). PMID: 27908841
37. This meta-analysis demonstrates that the GSTM1-null, GSTT1-null, and GSTM1/GSTT1 double-null genotypes are associated with increased bladder cancer risk. PMID: 27911277
38. the study findings allow us to conclude that the deletion genotypes of GSTM1 and GSTT1 are associated with infertility in Russian men. PMID: 29376593
39. this meta-analysis indicates that the combined effects of the GSTM1 and GSTT1 polymorphisms are associated with increased lung cancer risk in Asians, Caucasians, and Indians. PMID: 28427236
40. Our results suggest that GSTM1 and GSTT1 gene deletion/null gene polymorphisms are not a key modulators of the risk of developing colorectal cancer in Kashmiri population. PMID: 28485343
41. People with glutathione s-transferase enzyme gene variations (GSTM1 and GSTT1 deletions) are at a higher risk for developing multiple sclerosis, which can be due to a decrease in enzymatic activity and their levels in nerve cells and the brain. PMID: 29055472
42. The GSTM1-null genotype might be associated with higher risk for early onset severe mental disorders. PMID: 27114251
43. Findings suggest that the GSTM1 null genotype is a risk modifier for cutaneous melanoma. PMID: 27540835
44. We aimed to assess the impact of DE and allergen co-exposure on lung function and the influence of GSTM1 or GSTT1 variation.plasma protein carbonyl level 4h after co-exposure was higher in the individuals who have the GSTT1 null genotype PMID: 27151508
45. Review/Meta-analysis: GSTM1 null genotype is a low-penetrant risk factor for developing breast cancer in the Chinese population. PMID: 28164656
46. the presence of a GSTM1 *null and GSTT1 *null alleles were independent predictors for COPD in females. PMID: 27421065
47. Our meta-analysis revealed strong association of rs1048943 in CYP1A1, but a suggestive association of deletion polymorphisms in GSTT1 and GSTM1 with lung cancer, which provides a comprehensive insight on the overall effect of the polymorphic variants, reported in various case-control studies on Indian population, on the risk of lung cancer development PMID: 29076184
48. The selective effect of PEITC on detoxification in subjects lacking both GSTM1 and GSTT1 genes supports the epidemiologic findings of stronger protection by dietary isothiocyanates against the development of lung cancer in such individuals PMID: 27099270
49. Polymorphisms of GSTM1 is associated with lung cancer. PMID: 28770368
50. The loss of GSTM1 was significantly associated with incident kidney and heart failure, independent of traditional risk factors. These results suggest GSTM1 function is a potential treatment target for the prevention of kidney and heart failure PMID: 28720685

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HGNC: 4632

OMIM: 138350

KEGG: hsa:2944

STRING: 9606.ENSP00000311469

UniGene: Hs.301961