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  4. Recombinant Human GTP-binding protein Rhes (RASD2)

Recombinant Human GTP-binding protein Rhes (RASD2)

  • 中文名称：
    人RASD2重组蛋白
  • 货号：
    CSB-YP842653HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RASD2重组蛋白
  • 货号：
    CSB-EP842653HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RASD2重组蛋白
  • 货号：
    CSB-EP842653HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RASD2重组蛋白
  • 货号：
    CSB-BP842653HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RASD2重组蛋白
  • 货号：
    CSB-MP842653HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RASD2
  • Uniprot No.：
  • 别名：
    GTP binding protein Rhes; GTP-binding protein Rhes; MGC:4834; OTTHUMP00000197925; Ras homolog enriched in striatum; RASD 2; RASD family member 2; RASD2; Rhes; RHES_HUMAN; TEM 2; TEM2; Tumor endothelial marker 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-263
  • 氨基酸序列
    MMKTLSSGNC TLSVPAKNSY RMVVLGASRV GKSSIVSRFL NGRFEDQYTP TIEDFHRKVY NIRGDMYQLD ILDTSGNHPF PAMRRLSILT GDVFILVFSL DNRESFDEVK RLQKQILEVK SCLKNKTKEA AELPMVICGN KNDHGELCRQ VPTTEAELLV SGDENCAYFE VSAKKNTNVD EMFYVLFSMA KLPHEMSPAL HRKISVQYGD AFHPRPFCMR RVKEMDAYGM VSPFARRPSV NSDLKYIKAK VLREGQARER DKC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.
  • 基因功能参考文献：
    1. Study demonstrated that variation in the gene coding for RASD2 (rs6518956) affects in vivo prefrontal and striatal phenotypes in healthy human subjects that are relevant to schizophrenia PMID: 26228524
    2. Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion PMID: 26190541
    3. Findings reveal that ras homolog enriched in striatum is localized also in striatal cholinergic interneurons and, most importantly, lack of this G-protein, significantly alters dopamine D2 receptor modulation of striatal cholinergic excitability. PMID: 25818655
    4. Rhes is reduced in the brains of Huntington's disease patients. PMID: 25556834
    5. The findings of this study suggested that Rhes may play a crucial role in striatal iron homeostasis. PMID: 23999124
    6. Rhes robustly binds the autophagy regulator Beclin-1, decreasing its inhibitory interaction with Bcl-2 independent of JNK-1 signaling. PMID: 24324270
    7. The sequestering of Rhes through its binding to mutant huntingtin may decrease the ability of Rhes to perform vital physiological functions in the striatum neurons of Huntington disease patients. (Review) PMID: 23583659
    8. Rhes is an imidazoline-regulated transcript in pancreatic beta-cells PMID: 16945334
    9. Rhes can interfere with the functional activity of wt and mutated TSHr and with the respective hormone-stimulated cAMP production of FSHr and LHr. PMID: 17556863
    10. The genes RASD2 might be vulnerability genes for neuropsychologically defined subgroups of schizophrenic patients. PMID: 18571626
    11. Binding to the Gbeta subunits involves the cationic regions of AGS1 and Rhes, and Data used Rhes-AGS1 chimeras to show that their different cationic regions determine the Gbeta-specificity of the interactions. PMID: 19255495

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor.
  • 蛋白家族：
    Small GTPase superfamily, RasD family
  • 组织特异性：
    Pancreatic endocrine cells (islets of Langerhans).
  • 数据库链接：

    HGNC: 18229

    OMIM: 612842

    KEGG: hsa:23551

    STRING: 9606.ENSP00000216127

    UniGene: Hs.474711