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  4. Recombinant Human GRB2-associated-binding protein 2 (GAB2)

Recombinant Human GRB2-associated-binding protein 2 (GAB2)

  • 货号：
    CSB-YP892175HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP892175HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP892175HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP892175HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP892175HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    GAB 2; Gab2; GAB2_HUMAN; Grb 2 associated binder 2; GRB 2 associated binding protein 2; Grb2 associated binder 2; GRB2 associated binder 2 pp100; GRB2 associated binding protein 2; GRB2-associated binder 2; GRB2-associated-binding protein 2; Growth factor receptor bound protein 2 associated protein 2; Growth factor receptor bound protein 2-associated protein 2; KIAA0571; p97; PH domain containing adaptor molecule p97; pp100
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-676
  • 氨基酸序列
    MSGGGDVVCT GWLRKSPPEK KLRRYAWKKR WFILRSGRMS GDPDVLEYYK NDHSKKPLRI INLNFCEQVD AGLTFNKKEL QDSFVFDIKT SERTFYLVAE TEEDMNKWVQ SICQICGFNQ AEESTDSLRN VSSAGHGPRS SPAELSSSSQ HLLRERKSSA PSHSSQPTLF TFEPPVSNHM QPTLSTSAPQ EYLYLHQCIS RRAENARSAS FSQGTRASFL MRSDTAVQKL AQGNGHCVNG ISGQVHGFYS LPKPSRHNTE FRDSTYDLPR SLASHGHTKG SLTGSETDNE DVYTFKTPSN TLCREFGDLL VDNMDVPATP LSAYQIPRTF TLDKNHNAMT VATPGDSAIA PPPRPPKPSQ AETPRWGSPQ QRPPISENSR SVAATIPRRN TLPAMDNSRL HRASSCETYE YPQRGGESAG RSAESMSDGV GSFLPGKMIV GRSDSTNSED NYVPMNPGSS TLLAMERAGD NSQSVYIPMS PGAHHFDSLG YPSTTLPVHR GPSRGSEIQP PPVNRNLKPD RKAKPTPLDL RNNTVIDELP FKSPITKSWS RANHTFNSSS SQYCRPISTQ SITSTDSGDS EENYVPMQNP VSASPVPSGT NSPAPKKSTG SVDYLALDFQ PSSPSPHRKP STSSVTSDEK VDYVQVDKEK TQALQNTMQE WTDVRQSSEP SKGAKL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
  • 基因功能参考文献：
    1. Alzheimer's Disease risk variant rs2373115 is associated with increased NARS2 expression in brain. GAB2 expression is increased in AD brain tissue. PMID: 30088171
    2. Knockdown of Gab2 suppressed the activity of both PI3K/AKT and MAPK/ERK pathways in HER2-overexpressing breast cancer cells. PMID: 30326469
    3. these findings demonstrate that miR-485 may play tumour suppressive roles in Colorectal cancer (CRC)by directly targeting GAB2 and indirectly regulating AKT and ERK signalling pathways, suggesting that miR-485 may be a potential therapeutic target for patients with this disease PMID: 29781037
    4. Gab2 is overexpressed in UMs and plays an important role in UM invasion. Moreover, our findings suggest a novel role for Gab2 in modulating MMP-2, MMP-9, and fascin expression in regulating the invasion of UM tumor cells PMID: 28791340
    5. a common locus (rs3740677) in 3' UTR of GAB2 sequence which is targeted by the miRNA-185 was explored the probable associations of rs3740677 with risk for late-onset AD (LOAD) in a large scale case-control study from Chinese Han populations. PMID: 27311772
    6. we provided evidences to imply that miR-302c-3p downregulation in human RCC cells causes Gab2 over-expression, Akt hyper-activation and cell proliferation. PMID: 28412750
    7. study identified that GAB2 as an adaptor protein was preferentially induced in Th2 differentiation and regulated Th2 immune responses PMID: 28477539
    8. The proto-oncogene GAB2 (11q14.1) was significantly amplified in non-smokers patients and GAB2 protein was relatively up-regulated in non-smoker than smoker tissues. GAB2 may represent a potential biomarker for lung SCC in non-smokers PMID: 28960030
    9. Results show that up-regulation of Gab2 expression was found to be positively correlated with VEGF in colorectal cancer (CRC) tissues, and suggest that Gab2 promotes intestinal tumor growth and angiogenesis through upregulation of VEGF expression mediated by the MEK/ERK/c-Myc pathway. PMID: 28420432
    10. The model showed agreement at several key nodes, involving scaffolding proteins Gab1, Gab2 and their complexes with Shp2. VEGFR2 recruitment of Gab1 is greater in magnitude, slower, and more sustained than that of Gab2. As Gab2 binds VEGFR2 complexes more transiently than Gab1, VEGFR2 complexes can recycle and continue to participate in other signaling pathways. PMID: 23805312
    11. The s showed that GAB2 is cleaved at G238 during Coxsackievirus type B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676. PMID: 28361043
    12. Studied BAK1, SPRY4 and GAB2 SNPs in pediatric germ cell tumors(GCT); found a variant in SPRY4 was associated with reduced risk of GCT; a variant in BAK1 was positively associated with GCT with a strong estimated effect for testis tumors; and a SNP in GAB2 was associated with increased risk for GCT. PMID: 28295819
    13. overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating expression of CXCL1, CXCL2 and CXCL8 that is IKKbeta-dependent. PMID: 26657155
    14. GAB2 is a key intermediary between YAP/TAZ and the PI3K/AKT pathway. PMID: 28202507
    15. The findings of this study suggested that GAB2 rs2373115 may contribute to Alzheimer's disease susceptibility only in European population but not in East Asian population. PMID: 28320126
    16. ERK1 and ERK2 interact with Gab2 via a novel docking motif, which is required for subsequent Gab2 phosphorylation in response to ERK1/2 activation. PMID: 28096188
    17. GAB2 is a functional downstream target of miR-302a in glioma. GAB2 role in cell proliferation, migration and invasion of glioma. PMID: 28000880
    18. overexpression of GAB2 suppressed the expression of miR197 in glioblastoma cells. PMID: 27035789
    19. GAB2 might promote hepatocellular carcinoma (HCC) cell proliferation by enhancing ERK signaling. PMID: 27026230
    20. Data indicate that the most prominent proteins associating with Gab2 are PTPN11, PIK3R1 and ARID3B. PMID: 27025927
    21. Study shows that Gab2 is significantly upregulated in metastasis-positive colorectal cancer (CRC) tissues and suggest that it plays a vital role in regulating CRC metastasis and a potential target for diagnosis. PMID: 26754532
    22. Grb2-associated binder 2 silencing impairs growth and migration of non-small cell lung cancer cells via PI3K-Akt signaling. PMID: 26617767
    23. Gab2 may be involved in the onset and progression of HCC, but its expression is unable to serve as an independent prognosis factor in HCC patients. PMID: 27544933
    24. miR125a-5p acting as a novel Gab2 suppressor is partly down- regulated by DNA hypermethylation in glioma PMID: 25598421
    25. GAB2, GSPT1, TFDP2 and ZFPM1 are four new susceptibility loci for testicular germ cell tumor. PMID: 26503584
    26. Data indicate that high-grade serous ovarian carcinoma (HGSC) cell lines with high GRB2 associated binding protein 2 (GAB2) expression are more responsive to phosphatidylinositol 3-kinases (PI3K) inhibitor PF-04691502. PMID: 25852062
    27. Gab2 expression may play an important role in the progression of colorectal carcinoma. PMID: 26045784
    28. In colorectal cancer, miR-125b mediates PAR2-induced cancer cell migration by targeting Gab2. PMID: 26354435
    29. Upregulations of Gab1 and Gab2 proteins associate with tumor progression of human gliomas. PMID: 24998422
    30. Down-regulation of Gab2 has a protective function during M. tuberculosis infection, revealing a potential negative regulatory role for Gab2 in immunity to TB. PMID: 24805943
    31. Gab2 protein expression was remarkably reduced in temporal neocortex of TLE patients PMID: 24327320
    32. High Gab2 expression is associated with glioma. PMID: 23231021
    33. GAB2 has a role as an ovarian cancer oncogene, trnasforming immortalized ovarian and fallopian tube secretory epithelial cells PMID: 24385586
    34. the GAB2 gene may be associated with sporadic Alzheimer's disease risk. PMID: 24161894
    35. Gab2 may protect neurons against late-onset Alzheimer's disease. PMID: 23724096
    36. interactions between the GAB2 and GSK3B polymorphisms and the well-established genetic factor APOE may modify the overall risk of Alzheimer disease. PMID: 23525328
    37. GAB2 is a novel regulator of tumor angiogenesis in NRAS-driven melanoma PMID: 22926523
    38. results indicate that RSK directly phosphorylates Gab2 on 3 serine residues; findings show RSK-mediated Gab2 phosphorylation inhibits Shp2 recruitment, suggesting RSK mediates a negative-feedback loop that attenuates Gab2-dependent functions including cell motility PMID: 23401857
    39. these data underscore the critical roles of Gab1 and Gab2 in IL-22-mediated HaCaT cell proliferation, migration, and differentiation. PMID: 22851227
    40. These results define a novel role for Gab2 in mediating mucin gene expression and GCH; these findings have important implications for the pathogenesis and therapy of airway inflammatory diseases. PMID: 22859374
    41. significant association between the GAB2 gene and morphological brain differences in 755 young adult twins.(GAB2) has been shown to provide a 1.27-1.51 increased odds of developing late Alzheimer's. PMID: 22856364
    42. Gab2 overexpression, via activation of the PI3K-Zeb1 pathway, promotes characteristics of epithelial-to-mesenchymal transition in ovarian cancer cells PMID: 21996746
    43. Our findings implicate an association between genetic variations of GAB2 and Alzheimer disease in Han Chinese PMID: 21285854
    44. Both phosphatidylinositol (PI)-3 kinase and SH2 domain-containing protein tyrosine phosphatase (SHP)2 binding sites of Gab2 are required for mast cell degranulation and the anaphylaxis response. PMID: 21653832
    45. over-expressed in malignant lung tissues PMID: 21552417
    46. Gab2 regulates cytoskeletal organization and cell motility by regulating RhoA activation and binding to Shp2. PMID: 21118992
    47. The findings implicate GAB2 as a susceptibility gene for late-onset Alzheimer disease in Han Chinese. PMID: 21108942
    48. this study supports the association between the possibly protective GAB2 haplotype and the risk of late-onset Alzheimer's disease in APOEepsilon4 carriers PMID: 20888920
    49. GAB2 rs2373115 polymorphism was not a remarkable factor in developing Alzheimer disease among Mongolian. PMID: 20188796
    50. findings indicate that while Gab2 expression is not prognostic in breast cancer, its role in early disease evolution warrants further analysis PMID: 20087860

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  • 亚细胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    GAB family
  • 数据库链接：

    HGNC: 14458

    OMIM: 606203

    KEGG: hsa:9846

    STRING: 9606.ENSP00000354952

    UniGene: Hs.429434