Recombinant Human Forkhead box protein P2 (FOXP2)

1. To examine whether the variant in the FOXP2 gene contributes toward SCZ susceptibility, we carried out an association analysis of the SNP rs10447760 of the FOXP2 gene in a case-control study (1405 cases, 1137 controls) from China. We identified no association of rs10447760 in the FOXP2 gene with SCZ (P>0.05). A meta-analysis indicated that the SNP rs10447760 was not associated with susceptibility to SCZ in Han Chinese. PMID: 29346177
2. These findings suggest a novel miR-23a/FOXP2 link contributing to pancreatic ductal adenocarcinoma development and invasion. PMID: 29141872
3. Data confirmed that miR196b could directly bind to 3'UTR of FOXP2 mRNA and repress its expression. miR196b and FOXP2 showed a negative correlation in HCC tissues. More importantly, upregulation of FOXP2 antagonized miR196bmediated migration and invasion in Hep3B cells. Furthermore, FOXP2 knockdown partially reversed the antimetastatic function of the miR196b inhibitor on HCCLM3 cells. PMID: 29207173
4. SNPs in WNT2 and FOXP2 are associated with clinical symptom severity of autism spectrum disorders. PMID: 28081867
5. we have identified a novel de novo missense variant in FOXP1 that is identical to the most well-studied etiological variant in FOXP2. Functional characterization revealed clear similarities between these equivalent mutations in terms of their impact on protein function. PMID: 28741757
6. FOXP2 anomaly is either directly or indirectly associated with atypical development of widespread subcortical networks early in life. PMID: 27734906
7. Our findings suggest that the FOXP2 rs10447760 polymorphism may not contribute to the development of schizophrenia, but may contribute to the clinical symptoms of schizophrenia among Han Chinese PMID: 28421313
8. FOXP2 frontal cortex expression abnormalities were identified in Frontotemporal Degeneration patients. PMID: 27497476
9. Increased frequency of FOXP2 expression significantly correlated with FOXP1-positivity, and FOXP1 co-immunoprecipitated FOXP2 from activated B-cell-diffuse large B-cell lymphoma (ABC-DLBCL) cells. PMID: 27224915
10. These findings suggest that miR-139 plays a suppressive role in the regulation of osteosarcoma cell proliferation and migration via directly targeting FOXP2. PMID: 28993144
11. results provide evidence that FOXP2 SNPs influence aspects of human inner speech and fluency that are related to lateralized phenotypes, and suggest that the evolution of human language, as mediated by the adaptive evolution of FOXP2, involved features of inner speech PMID: 28609679
12. An intragenic deletion in FOXP2. PMID: 27572252
13. The proposes a binding model for the FOXP2 FHD that involves three types of binding sequence: low affinity sites which allow for rapid scanning of the genome by the protein in a partially unstructured state; moderate affinity sites which serve to locate the protein near target sites and high-affinity sites which secure the protein to the DNA . PMID: 28104810
14. FOXP2 can be modified with all three human SUMO proteins and that PIAS1 promotes this process. PMID: 26867680
15. FOXP2 is a substrate for SUMOylation and SUMOylation of FOXP2 plays a functional role in regulating its transcriptional activity. PMID: 26212494
16. CNTNAP2 is transcriptionally regulated by FOXP2. PMID: 26497390
17. Data suggest FOXP2 binds DNA as monomer; FOXP2 hinge loop domain mutants exhibit either decreased formation of homodimer (A539P) or decreased dissociation of homodimer (F541C); naturally occurring reverse mutation (P539A) increases DNA binding affinity. PMID: 26950495
18. Genetic variants in FOXP2 may be significant for rare forms of language impairment, they do not contribute appreciably to individual variation in the normal range as found in the general population. PMID: 27064276
19. Our results suggested that FOXP2 expression was downregulated in Hepatocellular carcinoma tumor tissues, and reduced FOXP2 expression was associated with poor overall survival PMID: 26142732
20. TBR1 homodimerizes; it interacts with FOXP2, a transcription factor implicated in speech/language disorders, and this interaction is disrupted by pathogenic mutations affecting either protein PMID: 25232744
21. FOXF2 deficiency enhances metastatic ability of BLBC cells by activating the EMT program through upregulating the transcription of TWIST1. PMID: 25848863
22. Random monoallelic expression impacts the haploinsufficiency phenotypes observed for FOXP2 mutations. PMID: 25422445
23. pH had a direct effect on FOXP2 binding to DNA affinity. PMID: 26055196
24. FOXP2 SNPs influence the use of speech sound learning strategies. PMID: 25995468
25. repression of expression is a feature of aggressive breast cancer, and an independent prognostic parameter for overall patient survival PMID: 25515522
26. These results indicate that language and speech ability is affected by an interaction between FOXP2 and MAOA, but not by either gene separately. PMID: 24356376
27. Foxp2(hum/hum) mice learn stimulus-response associations faster than their WT littermates in situations in which declarative and procedural forms of learning could compete during transitions toward proceduralization of action sequences. PMID: 25225386
28. These results reveal novel regulatory functions of the human FOXP2 3' UTR sequence and regulatory interactions between multiple miRNAs and the human FOXP2 gene. PMID: 25269856
29. Study provides an improved estimate of the contribution of mutations in GNPTAB, GNPTG and NAGPA to persistent stuttering, and suggests that variants in FOXP2 and CNTNAP2 are not involved in the genesis of familial persistent stuttering PMID: 24807205
30. Specific expression of FOXP2 in cerebellum improves ultrasonic vocalization in heterozygous but not in homozygous Foxp2 (R552H) knock-in pups. PMID: 24607928
31. Report of the first preliminary evidence for a gene-environment interaction in predicting the experience of auditory verbal hallucinations (AVHs) in people with schizophrenia-spectrum diagnoses, suggesting that FOXP2 may be a susceptibility gene for AVHs PMID: 24360035
32. Variation in FOXP2 may contribute to the inter-individual variability in hemispheric asymmetries for speech perception. PMID: 23911943
33. these results suggest FoxP2 modulates the development of neural circuits through regulating synaptogenesis and that SRPX2 is a synaptogenic factor that plays a role in the pathogenesis of language disorders. PMID: 24179158
34. No evidence for the association of FOXP2 and CNTNAP2 genes with language traits was observed in this analysis. PMID: 23277129
35. Among 12 genotyped SNPs only rs10447760 was located on the 5'UTR of FoxP2 and was significantly associated with schizophrenia (allelic P = 0.00069) and major depression (allelic P = 0.0011)in the Chinese Han population. PMID: 22404659
36. Molecular evolution of the FOXP2 gene and changes in the transcription regulation of gene expression. PMID: 23197593
37. Strong expression of the neuronal transcription factor FOXP2 is linked to an increased risk of early PSA recurrence in ERG fusion-negative prostate cancers. PMID: 23559350
38. FOXP2 targets show evidence of positive selection in European populations. PMID: 23602712
39. Our data do not support the previous hypothesis that the parental origin of FOXP2 alterations could influence the severity of speech impairment. PMID: 22105961
40. Foxp2 is implicated as a component of the neurobiological basis of sex differences in mammalian vocal communication. PMID: 23426656
41. study demonstrates inhibition of DISC1 promoter activity and protein expression by forkhead-box P2, a transcription factor implicated in speech and language function. PMID: 22434823
42. The single-marker and multiple-marker analyses showed an association between FOXP2 and combined Attention-deficit/hyperactivity disorder in the German cohort. PMID: 22504457
43. This paper will review evidence (referring to the <>FOXP2 as a leading example), try to suggest plausible reasons for such a perplexing output, and discuss if such reasons really explain the aetiology of language disorders--{REVIEW} PMID: 21652119
44. Genetic variations within FOXP2, APOE, and PRNP modulate primary progressive aphasia disease, leading to a specific regional hypoperfusion according to different molecular pathways. PMID: 22129783
45. Although FOXP2 transgene is expressed in many brain regions and has multiple roles during mammalian development, the protein affects the brain regions that are connected via cortico-basic ganglia circuits. PMID: 21111790
46. Word repetition in members affected by an inherited speech-language disorder is severely impaired, and brain activation is significantly reduced in the premotor, supplementary and primary motor cortices, as well as in the cerebellum and basal ganglia. PMID: 21576028
47. our data may hint at a role of FOXP2 genetic variants in dyslexia-specific brain activation and demonstrate use of imaging genetics in dyslexia research. PMID: 21897444
48. children found with a deletion involving the FOXP2 region should be evaluated for CAS PMID: 22144704
49. FOXP2 binds directly to the 5' regulatory region of MET, and overexpression of FOXP2 results in transcriptional repression of MET in fetal cerebral cortex. PMID: 21832174
50. These results suggest that FOXP2 is a binding partner for the nuclear translocation of POT1. PMID: 21684252

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HGNC: 13875

OMIM: 602081

KEGG: hsa:93986

STRING: 9606.ENSP00000386200

UniGene: Hs.282787