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  4. Recombinant Human Forkhead box protein L1 (FOXL1)

Recombinant Human Forkhead box protein L1 (FOXL1)

  • 货号：
    CSB-YP613276HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP613276HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP613276HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP613276HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP613276HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FOXL1
  • Uniprot No.：
  • 别名：
    FKH 6; FKH6; FKHL 11; FKHL11; Forkhead (Drosophila) like 11; Forkhead box L1; Forkhead box protein L1; Forkhead related protein FKHL11; Forkhead related transcription factor 7; Forkhead-related protein FKHL11; Forkhead-related transcription factor 7; FOX L1; FOXL 1; Foxl1; FOXL1_HUMAN; FREAC 7; FREAC-7; FREAC7
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-345
  • 氨基酸序列
    MSHLFDPRLP ALAASPMLYL YGPERPGLPL AFAPAAALAA SGRAETPQKP PYSYIALIAM AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN LSLNDCFVKV PREKGRPGKG SYWTLDPRCL DMFENGNYRR RKRKPKPGPG APEAKRPRAE THQRSAEAQP EAGSGAGGSG PAISRLQAAP AGPSPLLDGP SPPAPLHWPG TASPNEDAGD AAQGAAAVAV GQAARTGDGP GSPLRPASRS SPKSSDKSKS FSIDSILAGK QGQKPPSGDE LLGGAKPGPG GRLGASLLAA SSSLRPPFNA SLMLDPHVQG GFYQLGIPFL SYFPLQVPDT VLHFQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.
  • 基因功能参考文献：
    1. FOXL1 inhibited the proliferation, invasion, and migration of breast cancer.FOXL1 expression was reduced in breast cancer. PMID: 27938507
    2. our findings provide evidence that FOXL1 might serve as a candidate tumor suppressor and a potential prognostic biomarker for gastric cancer PMID: 26960689
    3. the downregulation of FOXL1 expression was associated with osteosarcoma cell growth. Restoration of FOXL1 gene expression by gene therapy may have a therapeutic potential for patients with osteosarcoma PMID: 26062977
    4. dysregulated FOXL1 is involved in tumorigenesis and progression of gallbladder cancer. PMID: 25010679
    5. results suggest that Foxl1 plays an inhibitory role in renal tumor progression. PMID: 24427331
    6. Lower FOXL1 expression is correlated with metastasis and advanced pathologic stage of pancreatic cancer. PMID: 23801748
    7. two novel de novo mutations in rare patients inherited gene variants in FOXL1. PMID: 21457232
    8. FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1. PMID: 21536545

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 3817

    OMIM: 603252

    KEGG: hsa:2300

    STRING: 9606.ENSP00000326272

    UniGene: Hs.533830