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  4. Recombinant Human Forkhead box protein F1 (FOXF1)

Recombinant Human Forkhead box protein F1 (FOXF1)

  • 货号：
    CSB-YP619641HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP619641HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP619641HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP619641HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP619641HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FOXF1
  • Uniprot No.：
  • 别名：
    AI450827; FKH L5; FKHL 5; FKHL5; Forkhead (Drosophila) like 5; Forkhead box F1; Forkhead box protein F1; Forkhead drosophila homolog like 5; Forkhead like 5; Forkhead related activator 1; Forkhead related protein FKHL5; Forkhead related transcription factor 1; Forkhead-related activator 1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1; FOX F1; FOXF 1; foxf1; FOXF1_HUMAN; FREAC 1; FREAC-1; FREAC1; HFH 8; MGC105125
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-379
  • 氨基酸序列
    MSSAPEKQQP PHGGGGGGGG GGGAAMDPAS SGPSKAKKTN AGIRRPEKPP YSYIALIVMA IQSSPTKRLT LSEIYQFLQS RFPFFRGSYQ GWKNSVRHNL SLNECFIKLP KGLGRPGKGH YWTIDPASEF MFEEGSFRRR PRGFRRKCQA LKPMYSMMNG LGFNHLPDTY GFQGSAGGLS CPPNSLALEG GLGMMNGHLP GNVDGMALPS HSVPHLPSNG GHSYMGGCGG AAAGEYPHHD SSVPASPLLP TGAGGVMEPH AVYSGSAAAW PPSASAALNS GASYIKQQPL SPCNPAANPL SGSLSTHSLE QPYLHQNSHN APAELQGIPR YHSQSPSMCD RKEFVFSFNA MASSSMHSAG GGSYYHQQVT YQDIKPCVM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Probable transcription activator for a number of lung-specific genes.
  • 基因功能参考文献：
    1. a novel cascade mediated by AP-1 and FOXF1 that regulates oncogene-induced senescence, is reported. PMID: 30119690
    2. circNASP contributes to malignant behaviors of osteosarcoma cells by miR-1253/FOXF1 pathway. PMID: 29678578
    3. the varients of FOXP1 and FOXF1 genes are functionally associated with oesophageal adenocarcinoma in Chinese population. PMID: 29666340
    4. gene polymorphism is associated with increased colorectal cancer risk in the Han Chinese population PMID: 28404937
    5. we describe monozygotic twins and one full-term newborn with ACD and gastrointestinal malformations caused by de novo mutations of FOXF1 on the maternal-inherited alleles. PMID: 28256047
    6. reported the first familial case of ACDMVP as a result of maternal somatic mosaic FOXF! mutation, which provided additional evidence for this novel imprinting disorder PMID: 27109257
    7. FOXF1 promotes prostate tumor growth and progression by activating ERK5 signaling PMID: 27165781
    8. the R139Q substitution in FOXF1 causes infantile hypertrophic pyloric stenosis in a family and implies a novel pathological pathway for the condition PMID: 27855150
    9. Single-nucleotide polymorphisms FOXF1 rs9936833 and MHC rs9257809 remained significantly associated with presence of gastroesophageal acid reflux. The association for risk allele C in FOXF1 rs9936833 and risk allele A in MHC rs9257809 with the presence of acid reflux suggests a potential pathophysiologic mechanism for the role of genetic influences in Barret Esophagus development. PMID: 26822871
    10. FOXF1 mutations may have an extremely variable phenotype, possibly as a result of somatic mosaicism and complex gene regulation. PMID: 27145217
    11. There were decreased levels of Gsa, FOXF1, CREB1, and phosphorylated CREB1 proteins in intestinal muscle layers of patients with chronic intestinal pseudo-obstruction, compared with tissues from controls. PMID: 28043906
    12. Data show that MeCP2 promotes gastric cancer (GC) cell proliferation via FOXF1-mediated Wnt5a/beta-Catenin signaling pathway, and suppresses GC cell apoptosis through MYOD1-mediated Caspase-3 signaling pathway. PMID: 28131747
    13. Results show that FoxF1 increases invasiveness of breast cancer cells by upregulating LOX. PMID: 26908052
    14. we provide supportive evidence that genetic variants at FOXP1, BARX1, and FOXF1 confer risk for the development of EAC. PMID: 26383589
    15. Point mutations of FOXF1 gene is associated with alveolar capillary dysplasia. PMID: 27071622
    16. Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association PMID: 26294094
    17. FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification. PMID: 26293303
    18. FOXF1 behaved not only as a reprogramming regulator that mediates stemness but also as a putative tumor suppressor that contributes to p21-regulated growth suppression during fusion process PMID: 25237908
    19. Data indicate that constitutional duplication of FOXF1 in humans is not associated with any pediatric lung abnormalities. PMID: 25472632
    20. we narrowed the regulatory region located ~272 kb upstream to FOXF1 to ~60 kb and showed that its loss correlated with a decrease of FOXF1 expression in vivo. PMID: 24842713
    21. FOXF1 was induced by the antifibrotic mediator Prostaglandin E2 and repressed by the profibrotic cytokine TGF-beta1, and FOXF1 repressed cell growth and collagen-1 expression in normal lung fibroblasts, consistent with participation in antifibrotic pathways. PMID: 25260753
    22. FOXF1 and p53 form a portion of a regulatory transcriptional network that appears to have an important role in cancer cell invasion and migration. PMID: 24186199
    23. Bmi1 and FoxF1 may cooperate with hedgehog signaling in non-small-cell lung carcinogenesis. PMID: 23864317
    24. Novel FOXF1 deep intronic deletion causes lethal lung developmental disorder, alveolar capillary dysplasia with misalignment of pulmonary veins. PMID: 23943206
    25. Case Report: heterozygous nonsense mutation c.539C>A;p.S180X in the first exon of FOXF1, in a patient with alveolar capillary dysplasia with misalignment of pulmonary veins associated with annular pancreas and intestinal malrotation. PMID: 23407133
    26. We identified two additional genic and eight genomic deletions upstream to FOXF1. These results corroborate and extend our previous observations and further establish involvement of FOXF1 in ACD/MPV and lung organogenesis. PMID: 23505205
    27. this study provides evidence that MHC rs9257809 and FOXF1 rs9936833 variants, associated with Barrett's esophagus, also increase esophageal carcinoma and esophageal adenocarcinoma susceptibility in Caucasians PMID: 23504527
    28. Deletions in the regulatory sequence of maternally inherited FOXF1 were identified in patients with persistent fetal circulation syndrome. PMID: 23034409
    29. findings show FOXF1 is frequently overexpressed in colorectal tumor epithelial cells and underexpressed/lost in tumor-associated stromal fibroblasts; identified that overexpressed FOXF1 proteins are mislocalized in the cytoplasm of tumor epithelial cells, which positively correlates with poor prognostic factors of colorectal cancer PMID: 23103611
    30. FOXF1 expression is predominantly silenced in breast and colorectal cancer cell lines with inactive p53 PMID: 21964066
    31. Results from mutational analysis of FOXF1 showed normal sequences and no genomic imbalances affecting the FOX gene cluster on chromosome 16q24 in the studied patients. PMID: 21315191
    32. FOFOXF1 was highly expressed in metastatic rhabdomyosarcoma, alveolar tumor samples and with a significant lower expression in non-metastatic samples PMID: 21271214
    33. Recognition of a specific syndrome is possible, one of several examples discussed being the recently described association of intestinal malrotation with alveolar capillary dysplasia, due to mutations in the forkhead box transcription factor FOXF1. PMID: 20549505
    34. FoxF1 was found to be a direct repressed target of NF1-C2; first evidence for a role of FoxF1 in cancer and regulation of EMT; overexpression associated with mesenchymal phenotype, increased invasiveness and enhanced growth of breast carcinoma xenografts PMID: 20145151
    35. Observations suggest that hedgehog-dependent FoxF1 is a clinically relevant lung CAF-inducing factor, and support experimentally the general concept that CAF properties can be induced by activation of developmentally important transcription factors. PMID: 20233876
    36. A role for FOXF1 in esophageal atresia, tracheoesophageal fistula and the VACTERL association is presented. PMID: 19822228
    37. A pattern of strong Shh expression with weak expression of Foxf1 in all cases of UIP (usual interstitial pneumonitis) and a complementary expression of Shh and Foxf1 in cases of nonspecific interstitial pneumonitis (NSIP-F). PMID: 16448649
    38. FOXF1 induces growth hormone variant expression by interaction with a FOXF1/FOXF2 cis-element in the proximal promoter PMID: 16772323
    39. Inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations. PMID: 19500772

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  • 相关疾病：
    Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in lung and placenta.
  • 数据库链接：

    HGNC: 3809

    OMIM: 265380

    KEGG: hsa:2294

    STRING: 9606.ENSP00000262426

    UniGene: Hs.155591