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  4. Recombinant Human Forkhead box protein D1 (FOXD1)

Recombinant Human Forkhead box protein D1 (FOXD1)

  • 货号：
    CSB-YP619085HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP619085HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP619085HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP619085HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP619085HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FOXD1
  • Uniprot No.：
  • 别名：
    Brain Factor 2; FKH L8; FKHL 8; FKHL8; Forkhead (Drosophila) like 8; Forkhead box D1; Forkhead box protein D1; Forkhead drosophila homolog like 8; Forkhead like 8; Forkhead related activator 4; Forkhead related protein FKHL8; Forkhead related transcription factor 4; Forkhead-related protein FKHL8; Forkhead-related transcription factor 4; FOX D1; FOXD 1; foxd1; FOXD1_HUMAN; FREAC 4; FREAC-4; FREAC4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-465
  • 氨基酸序列
    MTLSTEMSDA SGLAEETDID VVGEGEDEED EEEEDDDEGG GGGPRLAVPA QRRRRRRSYA GEDELEDLEE EEDDDDILLA PPAGGSPAPP GPAPAAGAGA GGGGGGGGAG GGGSAGSGAK NPLVKPPYSY IALITMAILQ SPKKRLTLSE ICEFISGRFP YYREKFPAWQ NSIRHNLSLN DCFVKIPREP GNPGKGNYWT LDPESADMFD NGSFLRRRKR FKRQPLLPPN AAAAESLLLR GAGAAGGAGD PAAAAALFPP APPPPPHAYG YGPYGCGYGL QLPPYAPPSA LFAAAAAAAA AAAFHPHSPP PPPPPHGAAA ELARTAFGYR PHPLGAALPG PLPASAAKAG GPGASALARS PFSIESIIGG SLGPAAAAAA AAQAAAAAQA SPSPSPVAAP PAPGSSGGGC AAQAAVGPAA ALTRSLVAAA AAAASSVSSS AALGTLHQGT ALSSVENFTA RISNC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells. Involved in transcriptional activation of PGF and C3 genes.
  • 基因功能参考文献：
    1. as well as stemness abilities but stronger senescence and higher apoptosis rate. CONCLUSION: We found that overexpression of miR-338-5p suppresses glioma cell proliferation, migration, and invasion and accelerates its senescence and apoptosis by decreasing FOXD1 expression via inhibition of activation of MAPK-signaling pathway. PMID: 30225541
    2. FOXD1 is overexpressed in osteosarcoma while MiR-30a-5p is lowexpressed. MiR-30a-5p directly regulates FOXD1 by binding its 3'-UTR. PMID: 29936179
    3. FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation PMID: 30158529
    4. FOXD1 promoted the expression of Plk2 mRNA and protein in colorectal cancer cells. PMID: 29864920
    5. Results showed that FOXD1 is a major actor in mammalian reproduction as sequence variants generated recurrent spontaneous abortion (RSA) and embryonic resorption (ER). Data propose that the FOXD1-p.429AlaAla mutation might be used as an RSA molecular marker while FOXD1 p.Ala88Gly variant might have a protective effect. PMID: 27805902
    6. our findings define a FOXD1-ALDH1A3 pathway in controling the clonogenic and tumorigenic potential of mesenchymal glioma stem-like cells in glioblastoma tumors PMID: 27569208
    7. The role of FOXD1 in glioma tumorigenesis, migration and progression.High FOXD1 expression in glioma. PMID: 28075458
    8. FOXD1 promotes breast cancer proliferation and chemotherapeutic drug resistance by targeting p27 PMID: 25462566
    9. Lung cancer patients with high FOXD1 expression survive for a significantly shorter time than those with low FOXD1 expression. PMID: 25550559
    10. In this review, we focus on the role of four specific FOX factors (FOXD1, FOXL2, FOXO1 and FOXP3) in gonadotropin hormone production PMID: 24099863
    11. the level of Smad6s can alter the level of TGF-beta and the subsequent induction of PAI-1 via a FoxD1 transcription site PMID: 15716278

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 3802

    OMIM: 601091

    KEGG: hsa:2297

    STRING: 9606.ENSP00000462795

    UniGene: Hs.519385