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  4. Recombinant Human Follistatin-related protein 3 (FSTL3)

Recombinant Human Follistatin-related protein 3 (FSTL3)

  • 货号：
    CSB-YP009026HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009026HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009026HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009026HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009026HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FSTL3
  • Uniprot No.：
  • 别名：
    FLRG; follistatin-like 3; follistatin-like 3 glycoprotein ; Follistatin-like protein 3; Follistatin-related gene protein; Follistatin-related protein 3; FSRP; Fstl3; FSTL3_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-263
  • 氨基酸序列
    MGSG NPAPGGVCWL QQGQEATCSL VLQTDVTRAE CCASGNIDTA WSNLTHPGNK INLLGFLGLV HCLPCKDSCD GVECGPGKAC RMLGGRPRCE CAPDCSGLPA RLQVCGSDGA TYRDECELRA ARCRGHPDLS VMYRGRCRKS CEHVVCPRPQ SCVVDQTGSA HCVVCRAAPC PVPSSPGQEL CGNNNVTYIS SCHMRQATCF LGRSIGVRHA GSCAGTPEEP PGGESAEEEE NFV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
  • 基因功能参考文献：
    1. FSTL3 expression in invasive breast cancer is inversely associated with tumor size and nuclear grade but it does not predict disease relapse in the short term. PMID: 28178680
    2. first trimester maternal serum levels not altered in women who develop gestational diabetes mellitus PMID: 27623975
    3. Human renal dysfunction is the strongest independent predictor of FSTL3 serum concentrations in multivariate analyses. PMID: 28339962
    4. The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower. PMID: 26898119
    5. FSTL3 is a critical mediator of exercise-dependent bone formation PMID: 25937185
    6. Elevated FSTL-3 concentrations were attributable to preeclampsia and were associated with increased likelihood of later developing preeclampsia, suggesting further study as a biomarker prior to clinically evident disease. PMID: 24700053
    7. The elevation of Follistatin-like-3 was demonstrated in late second trimester of pregnancy destined to developing preeclampsia, suggesting its causal role in the pathogenesis and prediction of preeclampsia. PMID: 24475769
    8. Resistance exercise resulted in a significant downregulation of MSTN and FBXO32 mRNA expression and a significant upregulation in FSTL3 and SMURF1 mRNA expression, and carbohydrate and protein feeding have little influence on the these markers expression. PMID: 22476926
    9. Suggest FSTL3 has a role in paracrine communication between cardiomyocytes and fibroblasts. PMID: 22915069
    10. Data suggest that serum levels of FSTL3 are higher in pre-eclampsia than in controls; placental expression of FSTL3 is also increased in pre-eclampsia compared with controls; no differences were observed between mild and severe pre-eclampsia. PMID: 22568578
    11. After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed higher levels of follistatin-like protein 3 while postmenopausal women using HT showed a significant increased expression over controls. PMID: 22395277
    12. Maternal and placental FSTL3 concentrations were reduced in GDM women compared with normally pregnant women, suggesting FSTL3 may play an important role in the pathogenesis of gestational diabetes PMID: 22122995
    13. Structure of myostatin.follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. PMID: 22052913
    14. GDF9 decreases basal and activin A-induced FST and FSTL3 expression, and this explains, in part, its enhancing effects on activin A-induced inhibin beta(B)-subunit mRNA expression and inhibin B production in hGL cells PMID: 21829661
    15. FLRG can be successfully detected in maternal plasma in the first trimester of pregnancy but its levels are not significantly altered in the presence of Down syndrome fetuses. PMID: 20063262
    16. First-trimester FSTL3 levels are associated with glucose intolerance and gestational diabetes later in pregnancy. PMID: 20007937
    17. Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function PMID: 11948405
    18. our present data suggest that protein kinase C and A signal transduction pathways differently regulate the expression of FLRG in human ovarian granulosa-luteal cells PMID: 12397211
    19. Follistatin and FLRG proteins downmodulate the effects of activin A and BMP2 on erythroid maturation. PMID: 12531697
    20. likely to be a local regulator of activin action in gonadal development and gametogenesis PMID: 14739256
    21. Data report the endometrial mRNA and peptide expression of follistatin-related gene (FLRG), a protein that binds activin-A, preventing its interaction. PMID: 15130517
    22. review discusses differences between signal targets of follistatin and FLRG and distinct functions and mechanisms for these two proteins in the human hematopoietic system PMID: 15451575
    23. comparison of the kinetics of FST isoform and FSTL3 biosynthesis, trafficking, and secretion PMID: 16150905
    24. IGFBP1 and Follistatin-like 3 are highly up-regulated in intrauterine growth restriction in the placenta. PMID: 16338475
    25. the differential biological actions among the FST isoforms and FSTL3 are primarily dependent on their relative cell-surface binding ability and ligand specificity PMID: 16627583
    26. Follistatin-like 3 expression was low in normal but enhanced in malignant rat liver. in human normal liver, in contrast, it was abundantly expressed but downregulated in liver cancer PMID: 16935389
    27. Ovarian endometriotic lesions show a deranged expression of activin A-binding proteins FLRG and follistatin, which may result in an altered effect of activin A on angiogenesis and/or endometrial differentiation. PMID: 17296189
    28. TNFalpha activates FLRG expression at the transcriptional level. PMID: 17395406
    29. Overexpression of FLRG, an antagonist of activin is associated with increased breast tumor cell growth PMID: 17671190
    30. Data show that the nuclear isoform of FLRG lacks an intrinsic transactivation domain, but enhances AF10-mediated transcription, probably through promoting the homo-oligomerization of AF10, thus facilitating the recruitment of co-activators. PMID: 17868029
    31. Hypoxia enhances the expression of FSTL3 and its release from PHT cells. PMID: 17959243
    32. Elevated myocardial expression of FST-like genes is a feature of heart failure, and may be linked to both disease severity and mechanisms underlying recovery. PMID: 18617621
    33. analysis of the structure of the FSTL3.activin A complex PMID: 18768470
    34. FLRG expression was regulated in the epithelial cytoplasm and nucleus of the malignant breast tissue. PMID: 19740438

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  • 相关疾病：
    A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
  • 亚细胞定位：
    [Isoform 1]: Secreted.; [Isoform 2]: Nucleus.
  • 组织特异性：
    Expressed in a wide range of tissues.
  • 数据库链接：

    HGNC: 3973

    OMIM: 605343

    KEGG: hsa:10272

    STRING: 9606.ENSP00000166139

    UniGene: Hs.529038