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  4. Recombinant Human Fibulin-1 (FBLN1)

Recombinant Human Fibulin-1 (FBLN1)

Unavailable
  • 货号：
    CSB-YP008452HU
  • 规格：
    ￥2208
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    FBLN1
  • Uniprot No.：
  • 别名：
    Basement membrane protein 90; BM 90; FBLN; Fbln1; FBLN1_HUMAN; FIBL 1; FIBL-1; FIBL1; Fibulin 1; Fibulin-1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Yeast
  • 分子量：
    77.3 kDa
  • 表达区域：
    30-703aa
  • 氨基酸序列
    DVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal Myc-tagged and C-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
  • 基因功能参考文献：
    1. FBLN1 and STK31 can be possible screening and differentiating biomarkers of colorectal cancer PMID: 29715435
    2. Fibulin-1 is expressed in breast cancer cell lines, interacts wtih SHBG, and is increased by estradiol PMID: 29940241
    3. This study demonstrated that FBLN1 can effectively promote osteogenic differentiation of human nasal inferior turbinate-derived mesenchymal stem cells into osteoblasts. PMID: 28445604
    4. This study demonstrated that fibulin-1 (FBLN1) was detected in the serums of Alzheimer disease patients PMID: 27911324
    5. Interestingly and in contrast with our expectation, we found that the expression level of FBLN-4 and BCRP were downregulated in tumor compared to adjacent normal tissues. FBLN-4 was associated with grade histology and therefore can be considered as a potential prognostic biomarker. PMID: 28282800
    6. Serum and vitreous fibulin-1 concentrations are elevated under diabetic retinopathy condition. PMID: 27422995
    7. Galectin-3 and fibulin-1 levels are elevated in heart failure patients with impaired glucose metabolism. Reduced LV contractile reserve among HF patients with DM does not to have an independent impact on plasma Gal-3 and fibulin-1 levels. PMID: 28068900
    8. changes in methylation levels in cfDNA associated with hepatocellular carcinoma and could represent useful plasma-based biomarker PMID: 28333958
    9. The FBLN1/FGF8 interaction may also be involved in the survival of neural crest cell population during development. PMID: 27402846
    10. Low expression of fibulin-1 is associated with gastric cancer. PMID: 26779638
    11. LDH associated positively with fibulin-1 (beta = 0.23; p < 0.001) and ROS (beta = 0.11; p = 0.30) in blacks only with cardiovascular disease. PMID: 26631026
    12. The procedure described is the first to our knowledge that enables a large scale purification of Fibulin-1 from human plasma. PMID: 26826315
    13. Study identifies a novel fibulin-1D variant, named fibulin-1D', comprising 638 amino acids with molecular weight of 70.5 kDa. Fibulin-1D' lacks a secretion sequence, has a truncated N-terminus domain and binds to the intracellular domain of integrin beta1. PMID: 25661773
    14. The purpose of this study was to develop and characterize robust quantitative assays for the emerging cardiovascular biomarker fibulin-1 and its circulating isoforms in human plasma. PMID: 25331251
    15. Extracellular matrix biomarker, fibulin-1 and its association with soluble uPAR in a bi-ethnic South African population PMID: 25456503
    16. Treatment with low-dose spironolactone reduced plasma fibulin-1 levels in patients with type 2 diabetes and resistant hypertension. PMID: 24739800
    17. fibulin-1 expression is associated with NMIBC grade and recurrence, it is epigenetically down-regulated and functions as a tumor suppressor gene and angiogenesis inhibitor in bladder cancer. PMID: 25234557
    18. Plasma fibulin-1 is independently associated with pulse wave velocity in type 2 diabetics. PMID: 23866070
    19. Increased levels of fibulin-1 were independently associated with higher levels of suPAR and NT-proBNP especially in patients with lower aortic valve stenosis PMID: 25014213
    20. Mutation of fibulin-1 causes a novel syndrome involving the central nervous system and connective tissues. PMID: 24084572
    21. FBLN1 functions as a novel candidate tumor suppressor gene in CM, and its downregulation may be due to promoter hypermethylation. PMID: 23907575
    22. Increased plasma fibulin-1 levels are associated with diabetes and impaired kidney function. PMID: 23294625
    23. Fibulin-1 is down regulated in renal cell carcinoma through promoter hypermethylation. PMID: 23391467
    24. In single regression analysis, NT-proBNP was significantly associated with fibulin-1 in African men and Caucasian women. PMID: 22349089
    25. Fibulin-1 is down-regulated in atrial tissue from patients with atrial fibrillation, perhaps reflecting the myocardial structural changes that may have taken place during arrhythmia. PMID: 20451270
    26. plasma levels of fibulin-1 could serve as a potential indicator to monitor kidney malfunction or kidney damage PMID: 21888404
    27. Fibulin-1 accumulates in the arterial wall and in plasma of patients with type 2 diabetes, and appears to be a factor associated with arterial extracellular matrix changes in type 2 diabetes. PMID: 21926180
    28. Promoter hypermethylation of FBLN1 was significantly associated with advanced stage hepatocellular carcinoma, multiple tumors and increased tumor size. PMID: 21268132
    29. data collectively suggest fibulin-1C may be worthy of further investigation as a target for airway remodeling in asthma PMID: 20967215
    30. Fibulin-1 protein was expressed in guinea pig sclera and cultured human scleral fibroblasts. PMID: 20405022
    31. the pattern of fibulin-1 within human atherosclerotic lesions and the potential for fibulin-1, perhaps derived from the blood and acting in conjunction with fibrinogen, to play a role in the etiology and cardiovascular disease progression PMID: 19693531
    32. Fibulin-1 has pronounced inhibitory effects on cell attachment and spreading promoted by fibronectin (FN) and suppresses the motility of a variety of cell types on FN substrates. PMID: 11792823
    33. structural and functional characterization of promoter PMID: 11829738
    34. FBLN1 disrupted by a t(12;22) translocation is associated with a complex type of synpolydactyly. PMID: 11836357
    35. binding of HPV E6 protein to fibulin-1 PMID: 12200142
    36. findings indicate that elevated expression and altered processing of fibulin-1 is associated with human breast cancer PMID: 12644824
    37. The gene responsible for a unique vitreoretinal dystrophy is located on chromosome 22q13. PMID: 12912698
    38. mutations in the splice acceptor site of fibulin-1 exon 19, but no MYH9 mutations,were found in family individuals affected by autosomal-dominant giant platelet syndromes associated with aberrant antisense gene regulation of the fibulin-1 gene. PMID: 14635206
    39. FBLN seems to have an immunological and pathobiological role in breast neoplasm surveillance. PMID: 14691454
    40. The preferential induction of the fibulin-1C variant, which is overexpressed in ovarian and breast cancer, might play an important role in estrogen-promoted carcinogenesis. PMID: 15528301
    41. fiblin-1 is an important molecule that mediates progesterone action in human endometrial stromal cells differentiation towards implantation PMID: 15774544
    42. fibulin-1 is a new regulator of ADAMTS-1-mediated proteoglycan proteolysis and may play an important role in proteoglycan turnover in tissues where there is overlapping expression PMID: 16061471
    43. Coexpression of fibulin-1 with GROalpha abrogates key aspects of the transformed phenotype, including colonic tumor formation in a murine xenograft model. PMID: 17062666
    44. degradation of basement membrane by cathepsin D liberates both fibulin-1 fragments and fibulin-5, which function to inhibit angiogenesis PMID: 18222970
    45. FBLN1 was identified as a novel candidate tmour suppressor gene epigenetically downregulated in gastric cancer PMID: 18985039
    46. Like tenascin-C, fibulin-1 inhibits fibroblast spreading and cell-mediated contraction of a fibrin-fibronectin matrix. PMID: 19109427
    47. fibulin-1 and -2 respond differentially to single and repeated damaging noxae, and their expression is differently present in liver cells PMID: 19609566

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  • 相关疾病：
    A chromosomal aberration involving FBLN1 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with RASSF8. Fibroblasts derived from a patient with synpolydactyly displayed alterations in the level of isoform D splice variant incorporated into the ECM and secreted into the conditioned culture medium. By contrast, the expression of isoform C was not perturbed in the patients fibroblasts. Furthermore, no aberrant polypeptides were detected in extracts of cultured patients fibroblasts. The translocation t(12;22) may result in haploinsufficiency of the isoform D splice variant, which could lead to the observed limb malformation.
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibulin family
  • 组织特异性：
    Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.
  • 数据库链接：

    HGNC: 3600

    OMIM: 135820

    KEGG: hsa:2192

    STRING: 9606.ENSP00000331544

    UniGene: Hs.24601