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  4. Recombinant Human F-box only protein 21 (FBXO21)

Recombinant Human F-box only protein 21 (FBXO21)

  • 货号：
    CSB-YP008488HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008488HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008488HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008488HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008488HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FBXO21
  • Uniprot No.：
  • 别名：
    DKFZp434G058; F box only protein 21; F box protein 21; F-box only protein 21; FBX21 ; FBX21_HUMAN; Fbxo21; FLJ90233; KIAA0875; MGC26682
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-628
  • 氨基酸序列
    MAAAAVDSAM EVVPALAEEA APEVAGLSCL VNLPGEVLEY ILCCGSLTAA DIGRVSSTCR RLRELCQSSG KVWKEQFRVR WPSLMKHYSP TDYVNWLEEY KVRQKAGLEA RKIVASFSKR FFSEHVPCNG FSDIENLEGP EIFFEDELVC ILNMEGRKAL TWKYYAKKIL YYLRQQKILN NLKAFLQQPD DYESYLEGAV YIDQYCNPLS DISLKDIQAQ IDSIVELVCK TLRGINSRHP SLAFKAGESS MIMEIELQSQ VLDAMNYVLY DQLKFKGNRM DYYNALNLYM HQVLIRRTGI PISMSLLYLT IARQLGVPLE PVNFPSHFLL RWCQGAEGAT LDIFDYIYID AFGKGKQLTV KECEYLIGQH VTAALYGVVN VKKVLQRMVG NLLSLGKREG IDQSYQLLRD SLDLYLAMYP DQVQLLLLQA RLYFHLGIWP EKSFCLVLKV LDILQHIQTL DPGQHGAVGY LVQHTLEHIE RKKEEVGVEV KLRSDEKHRD VCYSIGLIMK HKRYGYNCVI YGWDPTCMMG HEWIRNMNVH SLPHGHHQPF YNVLVEDGSC RYAAQENLEY NVEPQEISHP DVGRYFSEFT GTHYIPNAEL EIRYPEDLEF VYETVQNIYS AKKENIDE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
  • 基因功能参考文献：
    1. Ser291-phosphorylated form of the multifunctional protein and stem cell marker, CD44, inhibits FBXO21-directed degradation of P-gp. PMID: 26299618
    2. SCF(FBXO21) polyubiquitylates EID1 both in vitro and in vivo and is required for the efficient degradation of EID1 in both cycling and quiescent cells. PMID: 26631746
    3. The results suggest that EID1 is a bona fide substrate of FBXO21 and that the control of EID1 abundance by SCF(FBXO)(21) might affect the transcriptional repression activity of EID1. PMID: 26085330
  • 数据库链接：

    HGNC: 13592

    OMIM: 609095

    KEGG: hsa:23014

    STRING: 9606.ENSP00000328187

    UniGene: Hs.740376