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  4. Recombinant Human Endonuclease V (ENDOV)

Recombinant Human Endonuclease V (ENDOV)

  • 中文名称：
    人ENDOV重组蛋白
  • 货号：
    CSB-YP818733HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ENDOV重组蛋白
  • 货号：
    CSB-EP818733HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ENDOV重组蛋白
  • 货号：
    CSB-EP818733HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ENDOV重组蛋白
  • 货号：
    CSB-BP818733HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ENDOV重组蛋白
  • 货号：
    CSB-MP818733HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ENDOV
  • Uniprot No.：
  • 别名：
    ENDOVEndonuclease V; hEndoV; EC 3.1.26.-; Inosine-specific endoribonuclease
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-282
  • 氨基酸序列
    MALEAAGGPP EETLSLWKRE QARLKAHVVD RDTEAWQRDP AFSGLQRVGG VDVSFVKGDS VRACASLVVL SFPELEVVYE ESRMVSLTAP YVSGFLAFRE VPFLLELVQQ LREKEPGLMP QVLLVDGNGV LHHRGFGVAC HLGVLTDLPC VGVAKKLLQV DGLENNALHK EKIRLLQTRG DSFPLLGDSG TVLGMALRSH DRSTRPLYIS VGHRMSLEAA VRLTCCCCRF RIPEPVRQAD ICSREHIRKS LGLPGPPTPR SPKAQRPVAC PKGDSGESSA LC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing (Probable). Binds branched DNA structures.; Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Cleaves tRNAs containing inosine.; Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Cleaves tRNAs containing inosine.
  • 基因功能参考文献：
    1. hEndoV is redistributed to stress granules as a strategy to create a local environment low in ATP to permit hEndoV activity. PMID: 27573237
    2. Inosine-specific ribonuclease activity of natural variants of human endonuclease V PMID: 27800608
    3. ENDOV was significantly associated with schizophrenia. PMID: 25053281
    4. Human EndoV appears inactive on DNA, but has been shown to incise various RNA substrates containing inosine. [review] PMID: 25824682
    5. This previously unknown RNA incision activity may suggest a role for endonuclease V in normal RNA metabolism. PMID: 23912683
    6. hEndoV controls the fate of inosine-containing RNA in humans. PMID: 23912718
    7. ENDOV is localized in the cytoplasm and nucleoli of human cells. PMID: 23139746
    8. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20819778

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm. Nucleus, nucleolus. Cytoplasm, Stress granule.; [Isoform 6]: Cytoplasm. Nucleus, nucleolus. Cytoplasm, Stress granule.; [Isoform 7]: Cytoplasm. Nucleus, nucleolus. Cytoplasm, Stress granule.
  • 蛋白家族：
    Endonuclease V family
  • 数据库链接：

    HGNC: 26640

    KEGG: hsa:284131

    STRING: 9606.ENSP00000429190

    UniGene: Hs.389678