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  4. Recombinant Human E3 ubiquitin-protein ligase ZNRF2 (ZNRF2)

Recombinant Human E3 ubiquitin-protein ligase ZNRF2 (ZNRF2)

  • 中文名称：
    人ZNRF2重组蛋白
  • 货号：
    CSB-YP847746HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZNRF2重组蛋白
  • 货号：
    CSB-EP847746HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZNRF2重组蛋白
  • 货号：
    CSB-EP847746HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZNRF2重组蛋白
  • 货号：
    CSB-BP847746HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZNRF2重组蛋白
  • 货号：
    CSB-MP847746HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZNRF2
  • Uniprot No.：
  • 别名：
    E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; RNF202; Zinc/RING finger protein 2; Znrf2; ZNRF2_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-242
  • 氨基酸序列
    GAKQSGPAA ANGRTRAYSG SDLPSSSSGG ANGTAGGGGG ARAAAAGRFP AQVPSAHQPS ASGGAAAAAA APAAPAAPRS RSLGGAVGSV ASGARAAQSP FSIPNSSSGP YGSQDSVHSS PEDGGGGRDR PVGGSPGGPR LVIGSLPAHL SPHMFGGFKC PVCSKFVSSD EMDLHLVMCL TKPRITYNED VLSKDAGECA ICLEELQQGD TIARLPCLCI YHKGCIDEWF EVNRSCPEHP SD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
  • 基因功能参考文献：
    1. Results detected significantly higher levels of ZNRF2 in osteosarcoma cells (OS) and provide evidence that ZNRF2 enhances OS cell growth and improves survival against doxorubicin. PMID: 28416774
    2. These findings uncover ZNRF2 as a component of the amino acid sensing machinery that acts upstream of Rag-GTPases and the V-ATPase to activate mTORC1. PMID: 27244671
    3. ZNRF1 and ZNRF2 are new players in regulation of the ubiquitous Na(+)/K(+)ATPase that is tuned to changing demands in many physiological contexts. PMID: 22797923
    4. identification of ZNRF2; data suggest that ZNRF proteins play a role in the establishment and maintenance of neuronal transmission and plasticity via their ubiquitin ligase activity [ZNRF2] PMID: 14561866
  • 亚细胞定位：
    Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein.
  • 组织特异性：
    Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.
  • 数据库链接：

    HGNC: 22316

    OMIM: 612061

    KEGG: hsa:223082

    STRING: 9606.ENSP00000323879

    UniGene: Hs.263912