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  4. Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22), partial

Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22), partial

  • 中文名称：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22(ADAM22),partial,Yeast
  • 货号：
    CSB-YP865198HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22(ADAM22),partial,Yeast
  • 货号：
    CSB-EP865198HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22(ADAM22),partial,Yeast
  • 货号：
    CSB-EP865198HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22(ADAM22),partial,Yeast
  • 货号：
    CSB-BP865198HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22(ADAM22),partial,Yeast
  • 货号：
    CSB-MP865198HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ADAM22
  • Uniprot No.：
  • 别名：
    A disintegrin and metalloproteinase domain 22; ADA22_HUMAN; ADAM 22; ADAM metallopeptidase domain 22; adam22; and cysteine-rich protein 2; Disintegrin and metalloproteinase domain-containing protein 22; disintegrin-like; MDC 2; MDC2; Metalloproteinase disintegrin ADAM22 3; Metalloproteinase like disintegrin like and cysteine rich protein 2; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like; MGC149832
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.
  • 基因功能参考文献：
    1. the LGI1-ADAM22 complex functions as the trans-synaptic machinery for precise synaptic transmission PMID: 29670100
    2. ADAM22 is critically involved in miR-449a-reduced tamoxifen resistance of estrogen receptor-positive breast cancer cells as a direct target of miR-449a. PMID: 30278449
    3. these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy PMID: 27760137
    4. Disruption of LGI1-ADAM22 interaction reduces synaptic AMPA receptors in hippocampal neurons. PMID: 24227725
    5. Data suggest that ADAM22 plays roles in cell differentiation, cell migration, and resistance to endocrine therapy in breast cancer; ADAM22 may serve as biomarker for poor disease-free survival in breast cancer patients. [REVIEW] PMID: 23810013
    6. findings suggest that SRC-1 switches steroid-responsive tumors to a steroid-resistant state in which the SRC-1 target gene ADAM22 has a critical role PMID: 22072566
    7. Mutations in disintegrin domain sequence in ADAM22 gene is associted with reduced LGI4-binding abilities resulting in epilepsy. PMID: 20156119
    8. Transgenic leucine-rich glioma-inactivated 4 (Lgi4) and transgenic Adam22 proteins are both expressed in Schwann cells as well as in sensory neurons; binding of Lgi4 to axonal Adam22 is required on axons to drive myelin formation. PMID: 20220021
    9. role for the 14-3-3zeta/ADAM 22 association in the regulation of cell adhesion and related signaling events PMID: 12589811
    10. demonstrated a functional role for ADAM22/14-3-3 in cell adhesion and spreading PMID: 15882968
    11. ADAM22, a brain-specific cell surface protein, mediates growth inhibition using an integrin dependent pathway. It is expressed in normal brain but not in high-grade gliomas. PMID: 16385342
    12. This study indicated ADAM22 gene is probably not a major gene for this epilepsy syndrome. PMID: 17681454
    13. Differential coding potential of ADAM22 mRNAs. PMID: 17884303
    14. our results suggest that neither ADAM22 nor any of the three Kv1 channel genes are major causative genes for ADLTE. PMID: 18440780
    15. The pro domains of ADAMs are expressed as two subdomains. The most N-terminal subdomain (ADAM22-P(N)) was found to be susceptible to proteolysis and was required for folding stability of the second subdomain (ADAM22-P(C)). PMID: 18593599

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon.
  • 组织特异性：
    Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues.
  • 数据库链接：

    HGNC: 201

    OMIM: 603709

    KEGG: hsa:53616

    STRING: 9606.ENSP00000265727

    UniGene: Hs.256398