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  4. Recombinant Human DNA repair protein XRCC1 (XRCC1)

Recombinant Human DNA repair protein XRCC1 (XRCC1)

  • 货号：
    CSB-YP026229HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP026229HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP026229HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP026229HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP026229HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    DNA repair protein XRCC1; RCC; X ray repair complementing defective repair in chinese hamster; X ray Repair Complementing Defective Repair in Chinese Hamster Cells; X ray repair complementing defective repair in chinese hamster cells 1; X ray repair cross complementing 1; X ray repair cross complementing protein 1; X ray repair; complementing defective; repair in Chinese hamster; X-ray repair cross-complementing protein 1; XRCC 1; Xrcc1; XRCC1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-633
  • 氨基酸序列
    MPEIRLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE KEEQIHSVDI GNDGSAFVEV LVGSSAGGAG EQDYEVLLVT SSFMSPSESR SGSNPNRVRM FGPDKLVRAA AEKRWDRVKI VCSQPYSKDS PFGLSFVRFH SPPDKDEAEA PSQKVTVTKL GQFRVKEEDE SANSLRPGAL FFSRINKTSP VTASDPAGPS YAAATLQASS AASSASPVSR AIGSTSKPQE SPKGKRKLDL NQEEKKTPSK PPAQLSPSVP KRPKLPAPTR TPATAPVPAR AQGAVTGKPR GEGTEPRRPR AGPEELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR PDWTRDSTHL ICAFANTPKY SQVLGLGGRI VRKEWVLDCH RMRRRLPSRR YLMAGPGSSS EEDEASHSGG SGDEAPKLPQ KQPQTKTKPT QAAGPSSPQK PPTPEETKAA SPVLQEDIDI EGVQSEGQDN GAEDSGDTED ELRRVAEQKE HRLPPGQEEN GEDPYAGSTD ENTDSEEHQE PPDLPVPELP DFFQGKHFFL YGEFPGDERR KLIRYVTAFN GELEDNMSDR VQFVITAQEW DPSFEEALMD NPSLAFVRPR WIYSCNEKQK LLPHQLYGVV PQA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.
  • 基因功能参考文献：
    1. Polymorphic variants of XRCC1 Arg399Gln and XPD Lys751Gln are not associated with the risk of gastric cancer in the Kashmiri population. PMID: 30225185
    2. The effects of chronic smoking on oral mucosa led to the methylation of genes MRE11A PMS2, XRCC1 and MLH3, but resulted in a reduction of gene expression of MRE11A and PMS2, which showed >/=50% methylation. These results provide evidence that smoking cause methylation and reduced expression of repair genes. PMID: 29775861
    3. T-77C and Arg399Gln polymorphisms of the XRCC1 gene, as well as the 186C>T and Val158Met polymorphisms of the COMT gene, increased the risk of lung cancer in non-smoking women. PMID: 30109864
    4. XRCC1 Arg194Trp, Arg280His, and Arg399Gln did not affect overall survival after platinum-based chemotherapy in ovarian cancer patients. However, disease status could affect the relationship between Arg399Gln and overall survival in these patients PMID: 30407287
    5. results suggested an increased risk for Non-Hodgkin Lymphoma regarding the XRCC1 Arg194Trp polymorphism in a Romania population, while XRCC1 Arg399Gln polymorphism is not associated with Non-Hodgkin Lymphoma. PMID: 30148297
    6. Our present case-control study has shown that tryptophan allele (R/W-W/W genotype) in XRCC1A (Arg194Trp) gene significantly increased the risk of breast cancer 1.44-fold..the present case-control study did not reveal any significant association of XRCC3 (Thr241Met) polymorphism with the risk of breast cancer in females from NE region of India PMID: 29332455
    7. The C allele of rs861539 and T allele of rs1799782 Interaction between rs1799782 and obesity and haplotype T- C were all associated with increased papillary thyroid cancer risk. PMID: 30165355
    8. We confirmed that Arg399Gln polymorphism of XRCC1 gene is a potential predictor for susceptibility to NPC, especially for Asians PMID: 30095663
    9. Review/Meta-analysis: XRCC1 Arg399Gln polymorphism might be associated with genetic susceptibility to systemic lupus erythematosus in Asians and Caucasians. PMID: 28198159
    10. Infants born to women with specific AHR and XRCC1 genotypes may have higher genetic risks for birth weight reduction PMID: 28893607
    11. XRCC1 Arg399Gln and Arg194Trp variants may modify the susceptibility to gynecologic cancers based on ethnicity and type. PMID: 28391259
    12. the XRCC1 Arg399Gln GA variant might be risk alleles for cervical cancer susceptibility in the Chinese population (meta-analysis). PMID: 27487002
    13. studied SNPs in XRCC1 and XPD have no association with the incidence of age related cataract in the analyzed group of subjects. PMID: 28560653
    14. our data confirmed the individual susceptibility to BC resulting from polymorphic markers of DNA repair genes (XRCC1), apoptosis genes (TP53), as well as of apoptosis inhibition genes (MDM2). PMID: 29132330
    15. Meta-analysis: in Non-Small-Cell Lung Carcinoma patients treated with platinum-based regimen, XRCC1 194Arg allele suggest poor objective response rate, the GlnGln genotype of XRCC1 399 suggest poorer overall survival in Caucasian patients, and longer PFS in Asian patients. PMID: 28743242
    16. Our meta-analysis suggested that Arg399Gln in XRCC1 was associated with endometriosis risk. And especially in Asians, the A allele might be a preventive factor for this disease. PMID: 28926725
    17. Our results showed that DNA base excision repair proteins APE-1 and XRCC-1 are overexpressed in tongue squamous cell carcinoma and that XRCC-1 is associated with better clinical staging and nodal status. PMID: 27925687
    18. The effect of the XRCC1 gene homozygosity, particularly Arg/Arg, on the risk for stomach cancer was elevated by a high intake of vegetable oils and salt. PMID: 29020930
    19. DNA sequencing was performed for six single-nucleotide polymorphisms in the GSTP1, RAD51, XRCC1 and XRCC3 genes in BC patients and the control group. Two variants in the 5'-UTR of the XRCC3 and RAD51 genes showed a significant association with susceptibility to breast cancer. Additionally, s reported 2 mutations in intron 7 of the XRCC3 gene. PMID: 28315507
    20. The SNPs in CYP1A1, GSTP1 and XRCC1 genes did not show significant association with complete remission (CR) rate, overall survival (OS) or event free survival (EFS). However, XRCC1 Arg194Trp SNP was associated with higher drug toxicity; carriers of variant genotypes (CT and TT) had a significantly higher frequency of myelosuppression compared to those with the wild CC genotype PMID: 28844589
    21. TGFB1 T10C and XRCC1 G399A SNPs were associated with CC risk in univariate and multivariate analysis and displayed allele-dosage effects and coselection in cancer patients. Patients harboring the majority allele TGFB1 T10 (Leu) or the variant allele XRCC1 399A (Gln) have approximately 1.5-fold increased risk to develop CC. PMID: 28906311
    22. This meta-analysis suggests that no association between rs25487 or rs1799782 gene polymorphism and risk of female reproductive cancer risk was found. PMID: 28415705
    23. HOGG1 Ser326Cys, APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms are correlated with the risk and clinicopathological features of PACG. PMID: 28396513
    24. The current meta-analysis indicated that the XRCC1 Arg399Gln polymorphism decreased the risk of cervical cancer, while the Arg194Trp and Arg280His polymorphisms were not associated with cervical caner risk. [meta-anlalysis] PMID: 27903984
    25. On univariate analysis, a statistically significant association was found between risk of hepatocellular carcinoma(HCC) and XRCC1 399Arg/Gln genotype.To our knowledge, this is the first study reporting an association between base excision repair SNP and hepatocellular carcinoma risk in a population of central-southern Italy. PMID: 28058700
    26. This meta-analysis suggested that the XRCC1 Arg399Gln polymorphism was a risk factor for cutaneous melanoma in population-based subgroup. PMID: 26967970
    27. We demonstrated that infants whose mothers smoked during pregnancy with the combination of AHR, CYP1A1, and XRCC1 polymorphisms had lower birth size. PMID: 27592400
    28. Study suggested that RAD51, XRCC1, and XRCC3 polymorphisms may be predictive factors for radiation-induced acute toxicity in rectal cancer patients treated with preoperative combined therapy. PMID: 25811296
    29. Allelic variants in ERCC1 and ERCC2 are not associated with an increased risk of developing pre-senile cataract. The presence of Gln/Gln in XRCC1 in the pre-senile cataract group with regard to the group without cataract is associated with a major risk of developing pre-senile cataract. PMID: 27668351
    30. XRCC1 Arg399Gln Gln/Gln genotype, Gln allele, and homozygote variants of XRCC3 Thr241Met polymorphism may be a risk factor for predisposition of Oral Squamous Cell Carcinoma in Turkish. In addition, XRCC3 Thr241Met genotype could be associated with tumor size and level of daily smoking. PMID: 28639054
    31. XRCC1 polymorphism is associated with colorectal cancer. PMID: 29153096
    32. We demonstrated an association between six previously published single nucleotide polymorphisms (rs15869 [ BRCA2], rs1805389 [ LIG4], rs8079544 [ TP53], rs25489 [ XRCC1], rs1673041 [ POLD1], and rs11615 [ ERCC1]) and subsequent CNS tumors in survivors of childhood cancer treated by radiation therapy. PMID: 28976792
    33. our study provided preliminary evidence that the ERCC2 rs50872 T allele was associated with a favorable survival while the XRCC1 rs25487 A allele was associated with a worse survival outcome for advanced NSCLC patients. PMID: 27465648
    34. Study confirmed an association between XRCC1 codon 399 genotype and the risk of acute radiation dermatitis in locally advanced nasopharyngeal carcinoma patients during intensity-modulated radiation therapy. PMID: 29095251
    35. This study demonstrates that the presence of His allele and Gln allele in case of SULT1A1 rs9282861 and XRCC1 rs25487, respectively, involve in lung cancer prognosis in Bangladeshi population. PMID: 29110586
    36. XRCC1 Arg399Gln variant might not be risk alleles for breast cancer susceptibility in the Chinese population (Meta-Analysis) PMID: 28397459
    37. XRCC1 and PNKP interact via a high-affinity phosphorylation-dependent interaction site in XRCC1 and a forkhead-associated domain in PNKP. Data suggest a second PNKP interaction site in XRCC1 that binds PNKP with lower affinity and independently of XRCC1 phosphorylation. (XRCC1 = X-ray repair cross complementing protein 1; PNKP = polynucleotide kinase 3'-phosphatase) PMID: 28821613
    38. APEH interacts with the amino-terminal domain of XRCC1. Localization of APEH at sites of nuclear damage is mediated by direct interaction with XRCC1. PMID: 28866241
    39. XRCC1 Arg194 allele is a predicting factor for renal cell carcinoma. PMID: 28733204
    40. this updated and cumulative meta-analysis indicated that XRCC1 Arg194Trp polymorphism was associated with increased risk for glioma PMID: 28423490
    41. Results show that some polymorphic variants in XRCC1 and OGG1 are associated with increased DNA damage in Alzheimer's Disease. PMID: 27011006
    42. meta-analysis suggested that TT genotype in the Arg194Trp polymorphism contributes to the coronary artery disease susceptibility, particularly in the Asian population PMID: 28429350
    43. The interaction of OGG1 and XRCC1 DNA repair polymorphisms and arsenic exposure enhances telomeric DNA damage. PMID: 27084675
    44. either PARP1 or PARP2 are sufficient for near-normal XRCC1 recruitment at oxidative single-strand breaks PMID: 27965414
    45. contribution of microhomology-mediated end joining (MMEJ) to DNA double-strand break repair in the genome is affected by radiation exposure via enhancement of the formation of MMEJ-proficient XRCC1 complex PMID: 27994036
    46. Trp allele of codon 194 XRCC1 is a potential risk factor for breast cancer in Kurdish ethnicity. Furthermore, effect of this polymorphism on clinical and histological features of breast cancer was significant PMID: 27279507
    47. This study suggests that the genetic variant of XRCC1 rs25487 may contribute to the etiology of ischemic stroke. PMID: 27763529
    48. Individuals carrying theGSTP1 Ile-Ile or XRCC1399 Arg-Arg genotypes showed greater DNA damage than observed for other alleles. PMID: 28622826
    49. The current meta-analysis demonstrates that the XRCC1 Arg399Gln polymorphism confers susceptibility to autoimmune diseases in Asians and Caucasians and, in particular, shows that XRCC1 Arg399Gln polymorphism is associated with rheumatoid arthritis. PMID: 27812739
    50. Specific BER proteins required for processing a DNA substrate with a uracil adjacent to a cisplatin ICL. The lack of XRCC1 leads to increased DNA damage and results in increased cisplatin cytotoxicity. PMID: 28110804

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  • 相关疾病：
    Spinocerebellar ataxia, autosomal recessive, 26 (SCAR26)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).
  • 数据库链接：

    HGNC: 12828

    OMIM: 194360

    KEGG: hsa:7515

    STRING: 9606.ENSP00000262887

    UniGene: Hs.98493