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  4. Recombinant Human Cyclin-G2 (CCNG2)

Recombinant Human Cyclin-G2 (CCNG2)

  • 货号：
    CSB-YP621960HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP621960HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP621960HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP621960HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP621960HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CCNG 2; Ccng2; CCNG2 protein; CCNG2_HUMAN; Cyclin-G2; CyclinG2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-344
  • 氨基酸序列
    MKDLGAEHLA GHEGVQLLGL LNVYLEQEER FQPREKGLSL IEATPENDNT LCPGLRNAKV EDLRSLANFF GSCTETFVLA VNILDRFLAL MKVKPKHLSC IGVCSFLLAA RIVEEDCNIP STHDVIRISQ CKCTASDIKR MEKIISEKLH YELEATTALN FLHLYHTIIL CHTSERKEIL SLDKLEAQLK ACNCRLIFSK AKPSVLALCL LNLEVETLKS VELLEILLLV KKHSKINDTE FFYWRELVSK CLAEYSSPEC CKPDLKKLVW IVSRRTAQNL HNSYYSVPEL PTIPEGGCFD ESESEDSCED MSCGEESLSS SPPSDQECTF FFNFKVAQTL CFPS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in growth regulation and in negative regulation of cell cycle progression.
  • 基因功能参考文献：
    1. Low CCNG2 expression is associated with colorectal cancer. PMID: 30106441
    2. EGF-induced, calpain-mediated proteolysis contributes to the rapid destruction of cyclin G2 and that the PEST domain is critical for EGF/calpain actions PMID: 28640887
    3. Taken together, our novel findings demonstrate that cyclin G2 has potent tumor-suppressive effects in Epithelial ovarian cancer (EOC) by inhibiting EMT through attenuating Wnt/beta-catenin signaling. PMID: 26876206
    4. CycG2 contributes to signaling networks that limit breast cancer. PMID: 27753529
    5. CCNG2 knockdown eradicated the effects of miR-340 silencing. PMID: 27374211
    6. Neisseria meningitidis caused changes in the abundance of several cell cycle regulatory mRNAs, including the cell cycle inhibitors p21(WAF1/CIP1) and cyclin G2 in human brain microvascular endothelial cells. PMID: 26149128
    7. Upregulation of miR1246 mediated the malignant progression of colorectal cancer and is partly attributed to the downregulation of the expression of CycG2. PMID: 26573378
    8. miR-93-CCNG2 axis may be involved in Laryngeal squamous cell carcinoma proliferation and progression. PMID: 25309979
    9. Data shows the human CCNG2 and CDK4 expression of visceral adipose tissue are inversely associated with glucose and insulin resistance. PMID: 24708911
    10. Data (from studies using BeWo cells, a choriocarcinoma cell line, as model of placentation) suggest that miR-378a-5p (microRNA 378a) inhibits cell differentiation in syncytiotrophoblasts, in part, by down-regulating CCNG2 (cyclin G2) expression. PMID: 25122062
    11. miR-1246 expression was associated with chemoresistance and CSC-like properties via CCNG2, and could predict worse prognosis in pancreatic cancer patients PMID: 25117811
    12. Cyclin G2-involved invasion in vitro and in vivo. PMID: 24339739
    13. Low CCNG2 expression is associated with thyroid cancer. PMID: 24289643
    14. CCNG2 may play important roles as a negative regulator to kidney cancer ACHN cell by promoting degradation of CDK2. PMID: 24272084
    15. The level of CCNG2 was correlated with T stages, lymph node metastasis, clinic stage, and histological grade (P < 0.05) in colorectal carcinoma. PMID: 24307622
    16. CCNG2 may play important roles as a negative regulator to esophageal cancer cell by promoting degradation of CDK2. PMID: 24297335
    17. CCNG2 expression decreased in prostate cancer and correlated significantly with lymph node metastasis, clinic stage, and Gleason score. PMID: 24293374
    18. CCNG2 expression decreased in gastric cancer and correlated significantly T stages, lymph node metastasis, clinical stage, histological grade, and poor overall survival PMID: 24248541
    19. Regulation of cyclin G2 is a key mechanism whereby insulin, insulin analogues and IGF-I stimulate cell proliferation. PMID: 24059861
    20. These findings show that FOXA1, but not ER- alpha, is essential for AHR(aryl hydrocarbon receptor) -dependent regulation of CCNG2(cyclin G2 ), assigning a role for FOXA1 in AHR action. PMID: 22596188
    21. Our results suggest that CycG2 contributes to DNA damage-induced G(2)/M checkpoint by enforcing checkpoint inhibition of CycB1-Cdc2 complexes. PMID: 22589537
    22. These findings showed that Nodal signaling promotes cyclin G2 transcription by upregulating FoxO3a expression, inhibiting FoxO3a phosphorylation and enhancing its synergistic interaction with Smads. PMID: 21532621
    23. cyclin G2 also associates with various PP2A B' regulatory subunits, as previously shown for cyclin G1 PMID: 11956189
    24. ectopic expression of cyclin G2 inhibits cell proliferation PMID: 12452053
    25. Involved in progression and regulation of telomerase PMID: 16364039
    26. Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter PMID: 16608856
    27. Cyclin G2 may modulate the cell cycle and cellular division processes through modulation of PP2A and centrosomal associated activities. PMID: 17123511
    28. Cyclin G2 expression is modulated by HER2 signaling through multiple pathways including phosphoinositide 3-kinase, c-jun NH(2)-terminal kinase, and mTOR signaling. PMID: 18025271
    29. our results suggest that cotylenin A and rapamycin induce inhibition of cancer cell growth through the induction of cyclin G2. PMID: 18754885
    30. The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2. PMID: 18784254
    31. Cyclin G2 appears to be a negative cell-cycle regulator in gastric cancer, and its expression seems to be inversely related to gastric cancer progression. PMID: 19559447

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cyclin family, Cyclin G subfamily
  • 组织特异性：
    High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle.
  • 数据库链接：

    HGNC: 1593

    OMIM: 603203

    KEGG: hsa:901

    STRING: 9606.ENSP00000315743

    UniGene: Hs.740456