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  4. Recombinant Human Cyclin-G1 (CCNG1)

Recombinant Human Cyclin-G1 (CCNG1)

  • 货号：
    CSB-YP004820HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004820HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004820HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004820HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004820HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CCNG 1; CCNG; CCNG1; CCNG1_HUMAN; CYCG1; Cyclin G; Cyclin G1; Cyclin-G; Cyclin-G1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-295
  • 氨基酸序列
    MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR LRDFEVKDLL SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS CFYLAVKSIE EERNVPLATD LIRISQYRFT VSDLMRMEKI VLEKVCWKVK ATTAFQFLQL YYSLLQENLP LERRNSINFE RLEAQLKACH CRIIFSKAKP SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF WQELVSKCLT EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
  • 基因功能参考文献：
    1. miR-516b functions as a tumor suppressor by directly modulating CCNG1 expression in esophageal squamous carcinoma cells. PMID: 30119241
    2. Low CCNG1 expression is associated with cancer. PMID: 29787434
    3. Data show that the miR-27b/cyclin G1 protein (CCNG1)/p53 tumor suppressor protein (P53)/miR-508-5p axis plays important roles in gastric cancer (GC)-associated multidrug resistance (MDR). PMID: 26623719
    4. Results show that miR-23b may inhibit epithelial ovarian tumorigenesis and progression by targeting CCNG1 and modulating the expression of the relevant genes. PMID: 26872615
    5. OA induced cell cycle arrest in lung cancer cells through miR-122/Cyclin G1/MEF2D pathway. This finding may contribute to the understanding of the molecular mechanism of OA's anti-tumor activity PMID: 25472877
    6. Progesterone-induced cyclin G1 mediates the inhibitory effect of progesterone on endometrial epithelial cell proliferation. PMID: 25007270
    7. cyclin G1 exerts negative control on proliferation of endometrial carcinoma cells (ECCs). PMID: 23589924
    8. cyclin G1 levels were increased in normal tissue compared with hepatocellular carcinoma tissue and vary over the course of the cell cycle, with equal distribution between the nucleus and cytoplasm. PMID: 22835824
    9. data suggest that the deficiency of progesterone and its receptors is an important cause of the decreased expression of cyclin G1 in endometrial carcinoma, which may account for carcinogenesis and development of endometrial carcinomas PMID: 22649121
    10. Cyclin G1 overexpression enhanced Akt activation through interaction with p85 (regulatory subunit of phosphoinositide 3-kinase) PMID: 22271581
    11. Expression of cyclin G1 and G2 is strongly associated with nasopharyngeal carcinoma cell differentiation. PMID: 21688120
    12. Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity. PMID: 22105316
    13. Low expression of P27(kip1) and the high expression of cyclin G in patients acute leukemia may have some correlation with genesis and development of the disease. PMID: 19698214
    14. cyclin G1 has growth inhibitory activity that is mechanistically linked to ARF-p53 and pRb tumor suppressor pathways. PMID: 12556559
    15. does not increase significantly during colorectal carcinogenesis and during later metastasis to lymph nodes. PMID: 12684677
    16. cyclin G has a role in ATM-dependent p53 regulation and in cell cycle regulation during DNA damage PMID: 15077171
    17. cyclin G1 is a target of miR-122a in human hepatocellular carcinoma PMID: 17616664
    18. the cyclin box has a role in the proteasome-mediated degradation of cyclin G1 PMID: 18632610
    19. The B'alpha1 subunit of the serine/threonine protein phosphatase 2A, which binds to cyclin G1, can stabilize cyclin G1 under unstressed conditions and upon DNA damage, as well as inhibit the ability of cyclin G1 to be ubiquitinated. PMID: 18981217
    20. Results show that in patients resected for HCC, lower miR-122 levels were associated with a shorter TTR, whereas higher cyclin G1 expression was related to a lower survival, suggesting that miR-122 might represent an effective molecular target for HCC. PMID: 19584283

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  • 亚细胞定位：
    Nucleus. Note=DNA replication foci after DNA damage.
  • 蛋白家族：
    Cyclin family, Cyclin G subfamily
  • 组织特异性：
    High levels in skeletal muscle, ovary, kidney and colon.
  • 数据库链接：

    HGNC: 1592

    OMIM: 601578

    KEGG: hsa:900

    STRING: 9606.ENSP00000344635

    UniGene: Hs.79101