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Recombinant Human Cortistatin (CORT)

  • 中文名称：
    Recombinant Human Cortistatin(CORT),Yeast
  • 货号：
    CSB-YP005821HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Cortistatin(CORT),Yeast
  • 货号：
    CSB-EP005821HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Cortistatin(CORT),Yeast
  • 货号：
    CSB-EP005821HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Cortistatin(CORT),Yeast
  • 货号：
    CSB-BP005821HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Cortistatin(CORT),Yeast
  • 货号：
    CSB-MP005821HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CORT
  • Uniprot No.：
  • 别名：
    CORT; UNQ307/PRO350Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-17]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    77-105
  • 氨基酸序列
    QEGA PPQQSARRDR MPCRNFFWKT FSSCK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
  • 基因功能参考文献：
    1. Patients with newly diagnosed type 2 diabetes mellitus had lower plasma levels of vortistatin (CST) than healthy controls, and plasma CST was associated with glucose metabolism and insulin resistance. PMID: 28526556
    2. There is a relationship between plamsa CST and BCKDK in sepsis patients. PMID: 27773658
    3. Cortistatin emerges as a natural endogenous regulator of smooth muscle cells under pathological conditions and an attractive candidate for the pharmacological management of vascular diseases that course with neointimal lesion formation. PMID: 23595952
    4. Identifies post-translational cleavage products of the homologous rat protein. PMID: 10461921
    5. The cortistatin expression in the temporal lobe of Alzheimer's disease patients is decressed. PMID: 20164562
    6. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. PMID: 12161511
    7. first extensive study demonstrating that lymphoid tissues and immune cells express different levels of CST mRNA and that its expression can be regulated; hypothesize a role as an endogenous ligand of at least the sst2 receptor in the immune system PMID: 12519865
    8. study demonstrates for the first time a selective and inducible expression of the recently discovered cortistatin, as well as somatostatin receptor 2, in human monocyte-derived cells PMID: 12684217
    9. cortistatin-14 shown to be a high affinity ligand for G protein coupled receptor MrgX2 which is expressed in dorsal root ganglion PMID: 12915402
    10. Cortistatin plays a role in the auto/paracrine regulation of the endocrine pancreas PMID: 14669820
    11. Intravitreous somatostatin-like immunoreactivity deficit occurs in ptients with proliferative diabetic retinopathy. PMID: 16043736
    12. Human immune cells produce CST, whereas macrophage lineage and activated endothelium express sst2, and human lymphocytes express sst3. The human thymus expresses sst1, 2, 3, MrgX2 and almost all immune cells express GHS-R. [review] PMID: 18450367
    13. A lower expression of CST exists in diabetic retinas and it is associated with retinal neurodegeneration. PMID: 18709137

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Somatostatin family
  • 组织特异性：
    Expressed in a subset of GABAergic cells in the cortex and hippocampus.
  • 数据库链接：

    HGNC: 2257

    OMIM: 602784

    KEGG: hsa:1325

    STRING: 9606.ENSP00000366248

    UniGene: Hs.412311