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  4. Recombinant Human Condensin-2 complex subunit H2 (NCAPH2)

Recombinant Human Condensin-2 complex subunit H2 (NCAPH2)

  • 中文名称：
    人NCAPH2重组蛋白
  • 货号：
    CSB-YP746912HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NCAPH2重组蛋白
  • 货号：
    CSB-EP746912HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NCAPH2重组蛋白
  • 货号：
    CSB-EP746912HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NCAPH2重组蛋白
  • 货号：
    CSB-BP746912HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NCAPH2重组蛋白
  • 货号：
    CSB-MP746912HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NCAPH2
  • Uniprot No.：
  • 别名：
    CAP H2; CAP H2 subunit of the condensin II complex; CAPH2; Chromosome associated protein H2; Chromosome-associated protein H2; CNDH2_HUMAN; Condensin-2 complex subunit H2; hCAP H2; hCAP-H2; Kleisin beta; Kleisin-beta; Ncaph2; Non SMC condensin II complex subunit H2; Non-SMC condensin II complex subunit H2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-605
  • 氨基酸序列
    MEDVEARFAH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDEGKTT MNFIEAALLI QGSACVYSKK VEYLYSLVYQ ALDFISGKRR AKQLSSVQED RANGVASSGV PQEAENEFLS LDDFPDSRTN VDLKNDQTPS EVLIIPLLPM ALVAPDEMEK NNNPLYSRQG EVLASRKDFR MNTCVPHPRG AFMLEPEGMS PMEPAGVSPM PGTQKDTGRT EEQPMEVSVC RSPVPALGFS QEPGPSPEGP MPLGGGEDED AEEAVELPEA SAPKAALEPK ESRSPQQSAA LPRRYMLRER EGAPEPASCV KETPDPWQSL DPFDSLESKP FKKGRPYSVP PCVEEALGQK RKRKGAAKLQ DFHQWYLAAY ADHADSRRLR RKGPSFADME VLYWTHVKEQ LETLRKLQRR EVAEQWLRPA EEDHLEDSLE DLGAADDFLE PEEYMEPEGA DPREAADLDA VPMSLSYEEL VRRNVELFIA TSQKFVQETE LSQRIRDWED TVQPLLQEQE QHVPFDIHTY GDQLVSRFPQ LNEWCPFAEL VAGQPAFEVC RSMLASLQLA NDYTVEITQQ PGLEMAVDTM SLRLLTHQRA HKRFQTYAAP SMAQP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. Seems to have lineage-specific role in T-cell development.
  • 基因功能参考文献：
    1. Results suggest that DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy through apoptosis PMID: 27356276
    2. DNA methylation in the NCAPH2/LMF2 promoter region is significantly decreased in Alzheimer disease. PMID: 26742120
    3. CAPH2 protein accumulates as cells approach senescence, and knockdown of CAPH2 inhibits senescence. PMID: 26017022
    4. The CAP-H2 subunit of the condensin II complex implicated in chromosome assembly and segregation PMID: 14532007
  • 亚细胞定位：
    Nucleus. Chromosome. Note=Distributed along the arms of chromosomes assembled in vivo and in vitro.
  • 蛋白家族：
    CND2 H2 (condensin-2 subunit 2) family
  • 数据库链接：

    HGNC: 25071

    OMIM: 611230

    KEGG: hsa:29781

    STRING: 9606.ENSP00000299821

    UniGene: Hs.730607