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  4. Recombinant Human Coiled-coil domain-containing protein 134 (CCDC134)

Recombinant Human Coiled-coil domain-containing protein 134 (CCDC134)

  • 中文名称：
    Recombinant Human Coiled-coil domain-containing protein 134(CCDC134),Yeast
  • 货号：
    CSB-YP863989HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Coiled-coil domain-containing protein 134(CCDC134),Yeast
  • 货号：
    CSB-EP863989HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Coiled-coil domain-containing protein 134(CCDC134),Yeast
  • 货号：
    CSB-EP863989HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Coiled-coil domain-containing protein 134(CCDC134),Yeast
  • 货号：
    CSB-BP863989HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Coiled-coil domain-containing protein 134(CCDC134),Yeast
  • 货号：
    CSB-MP863989HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CCDC134
  • Uniprot No.：
  • 别名：
    CC134_HUMAN; ccdc134; coiled-coil domain containing 134; Coiled-coil domain-containing protein 134; dJ821D11.3; FLJ22349; MGC21013
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-229
  • 氨基酸序列
    TLRTSLDP SLEIYKKMFE VKRREQLLAL KNLAQLNDIH QQYKILDVML KGLFKVLEDS RTVLTAADVL PDGPFPQDEK LKDAFSHVVE NTAFFGDVVL RFPRIVHYYF DHNSNWNLLI RWGISFCNQT GVFNQGPHSP ILSLMAQELG ISEKDSNFQN PFKIDRTEFI PSTDPFQKAL REEEKRRKKE EKRKEIRKGP RISRSQSEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling.; In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
  • 基因功能参考文献：
    1. CCDC134 may also act as a novel regulator of human alteration/deficiency in activation 2a, and be involved in the p300-CBP-associated factor complex and affect its acetyltransferase activity PMID: 29115376
    2. CCDC134 promotes cell proliferation through the JAK3-STAT5 pathway. PMID: 25125657
    3. The attenuated expression of CCDC134 promoted the activation of Erk1/2 and JNK/SAPK, but had no effect on p38 in gastric cancer. PMID: 23070808
    4. CCDC134 might act as a novel regulator of hADA2a, and plays roles in the PCAF complex via hADA2a to affect its acetyltransferase activity and UV-induced DNA damage repair. PMID: 22644376
    5. These results clearly indicate that CCDC134 is a novel member of the secretory family and down-regulates the Raf-1/MEK/ERK and JNK/ SAPK pathways. PMID: 18087676

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Secreted. Endoplasmic reticulum.
  • 蛋白家族：
    CCDC134 family
  • 组织特异性：
    Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level). Also detected in placenta. Highest expression in
  • 数据库链接：

    HGNC: 26185

    KEGG: hsa:79879

    STRING: 9606.ENSP00000255784

    UniGene: Hs.474991