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  4. Recombinant Human Cell surface glycoprotein CD200 receptor 1 (CD200R1), partial

Recombinant Human Cell surface glycoprotein CD200 receptor 1 (CD200R1), partial

  • 货号：
    CSB-YP851547HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP851547HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP851547HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP851547HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP851547HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CD 200R; CD200 cell surface glycoprotein receptor; CD200 receptor 1; Cd200r1; Cell surface glycoprotein CD200 receptor 1; Cell surface glycoprotein OX2 receptor 1; Cell surface glycoprotein OX2 receptor; cell surface glycoprotein receptor CD200; CRTR 2; CRTR2; HCRTR2; MO2R1_HUMAN; MOX2 receptor; MOX2R; OX2R
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
  • 基因功能参考文献：
    1. Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis PMID: 27929051
    2. we demonstrated for the first time that CD200R is highly expressed on cells involved in type 2 immune responses, namely on Th2, Tc2, ILC2, and basophils. All these cell types play a role in type 2 inflammation. PMID: 28106273
    3. Residual CD200 activity may prevent completion of abortions via induction of Treg cells. In chronic histiocytic intervillositis, infiltrating maternal effector T cells may block Treg induction. An autocrine role for CD200-CD200R interaction versus inhibition of soluble CD200 by soluble CD200R is discussed. PMID: 28326648
    4. MMP12-producing monocyte-derived cells in gingival tissue of periodontitis patients also had reduced CD200R surface levels. Treatment with a CD200R ligand reduced CSF2-induced MMP12 production in these cells. This novel association of the CD200/CD200R pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression. PMID: 29101312
    5. Coexpression of CD200R-CD28 enhances function in WT1-specific T-cell receptor - transduced human primary T cells. PMID: 29042364
    6. Our findings suggest a promising role of CD200R as a prognostic marker in predicting elevated recurrence and reduced survival, and a potential therapeutic target in treating hepatocellular carcinoma. PMID: 27562325
    7. we revealed a critical role for CD200R signaling in limiting the growth and metastasis of CD200(+) tumors. PMID: 27385779
    8. Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages. PMID: 26923638
    9. Inflammatory Bowel Disease patients showed a significant decrease in the percentage of plasmacytoid dendritic cells and myeloid dendritic cells expressing CD200R1 compared to that of the control group. PMID: 26690123
    10. CD200-CD200R1 signaling may be required for human pregnancy success. PMID: 26123445
    11. This is the first report of CD200R1 expression by human epithelial tumor cells, and specifically, early-stage human breast cancer cells. It is also the first report of CD200R1 expression by term placental villous trophoblasts. PMID: 26011475
    12. data show that the expression of CD200R, CD95 and CD95L was influenced by cardiac surgery and imply the role of these membrane molecules in cell regulation-inhibition and apoptosis following cardiac surgery. PMID: 25404054
    13. The s showed that the viral orthologues e127 from rat cytomegalovirus and K14 from human herpesvirus 8 do not bind the activating CD200R-like proteins from their respective species, although they do bind the inhibitory receptors. PMID: 26538068
    14. The proportion of CD200R1+ cells in PBMCs, peripheral CD14+ cells and CD4+ T cells was significantly lower in rheumatoid arthritis patients compared to controls. PMID: 25261692
    15. We demonstrate a significant correlation between CD200R1 positive cells and disease severity in rheumatoid arthritis (RA) patients, thus indicating the relevance of the CD200/CD200R1 signaling pathway potential involvement in the pathogenesis of RA. PMID: 24496593
    16. The mechanism underlying ESA might be associated with enhanced expression of CD200 and CD200R in the trophoblast, leading to an upregulation of the immune response during the first trimester of pregnancy. PMID: 25145957
    17. The expression of CD200R as well as B7-H4 co-stimulatory molecules on CD14(+) cells were significantly higher in cord blood when compared with peripheral blood. PMID: 23066977
    18. Measurement of sCD200 and/or sCD200R1 may prove a useful and rapid means of monitoring subjects at risk of bone loss. PMID: 24333170
    19. [review] CD200R1 is comparable to other pathogen-targeted inhibitory receptors; its signaling pathway is utilized by a diverse number of pathogens and represents a novel targeting strategy for infectiouis diseases. PMID: 24388216
    20. Mesenchymal stem cells, through the expression of CD200, play a major role in the regulation of bone resorption and bone physiology and the CD200-CD200R couple could be a new target to control bone diseases. PMID: 23940819
    21. The expression of CD200 and its receptor, CD200R, on CD83+ monocyte-derived dendritic cells (Mo-DCs), pulsed or not with autologous tumor cell lysates (aTCL) in patients who suffer from laryngeal carcinoma, were examined. PMID: 23690219
    22. blocking CD200 on tumor cells may have opposite effects on tumor proliferation depending on the "affinity" of the macrophages to form the CD200-CD200R-complex with tumor cells. PMID: 23541619
    23. CD200 and CD200R1 expression and function are abnormal in systemic lupus erythematosus PMID: 22621248
    24. in cutaneous squamous cell carcinoma, CD200 expression on local blood vessels may promote tumor progression by suppressing CD200R myeloid cells during diapedesis PMID: 23560298
    25. Mesenchymal stromal cells are able to modulate the expression of both CD200 and CD200R on some T-cells. PMID: 22575528
    26. these results indicate a role of CD200R:CD200 in T cell responses to helminths which has diagnostic and prognostic relevance as a marker of infection for chronic schistosomiasis in mouse and man. PMID: 22496920
    27. Mechanistically, Kaposi's sarcoma-associated herpesvirus viral OX2 protein and CD200 expression on antigen presenting cells suppressed the phosphorylation of ERK1/2 mitogen-activated protein kinase in responding T cells. PMID: 22491458
    28. The role of the CD200-CD200R axis in bone marrow-derived mesenchymal stem cell mediated immunosuppression was studied using THP-1 human macrophages. PMID: 22363701
    29. Dok1 negatively regulates Dok2-mediated CD200R signaling through the recruitment of CrkL. PMID: 21078907
    30. results suggest an intrinsic abnormality in the CD200-CD200R signaling in monocyte-derived macrophages during aging and, especially, in Parkinson disease PMID: 19924532
    31. The CD200 receptor gene family resembles the signal regulatory proteins and killer Ig-related receptors in having receptor family members with potential activatory and inhibitory functions that may play important roles in immune regulation and balance. PMID: 12960329
    32. Human Herpesvirus-8 K14 protein interacts with human CD200R during the lytic cycle. Despite sharing only 40% primary sequence identity, K14 and CD200 interacts with CD200R with an almost identical and low affinity (K(D) = 0.5 microM) PMID: 15220441
    33. CD200R represents a novel and potent inhibitory receptor that can be targeted in vivo to regulate mast cell-dependent pathologies. PMID: 15661892
    34. Human CD200R is an important regulatory molecule of basophil activation. PMID: 16177086
    35. Reactions with CD200 antigen modulate immunomodulation for prevention of undesired immune responses of the skin. PMID: 16354172
    36. In human tonsils, CD200R is differentially expressed on B cells, with high expression on memory cells and plasmablasts. PMID: 17714785
    37. Review highlights the close correlation between CD200-CD200 receptor (CD200R), microglia activation, and Parkinson's disease. PMID: 18040859
    38. The CD200-CD200R pathway seems of critical relevance for macrophage-mediated damage in autoimmune inflammation of the CNS. PMID: 18164423
    39. CD200-mediated immune suppression may occur not only via neuron-microglia interactions, but also via glia-glia interactions, especially in inflammatory conditions in which an immune-suppressive environment needs to be restored. PMID: 19151626
    40. CD200R inhibits the activation of human myeloid cells through direct recruitment of Dok2 and subsequent activation of RAS p21 protein activator 1. PMID: 19786546

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
  • 蛋白家族：
    CD200R family
  • 组织特异性：
    Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and
  • 数据库链接：

    HGNC: 24235

    OMIM: 607546

    KEGG: hsa:131450

    UniGene: Hs.309158