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  4. Recombinant Human Caspase-5 (CASP5), partial

Recombinant Human Caspase-5 (CASP5), partial

  • 货号：
    CSB-EP004550HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Apoptosis related cysteine protease; CASP-5; CASP5; CASP5_HUMAN; Caspase-5 subunit p10; ICE(rel)-III; ICERELIII; ICH 3; ICH 3 protease; Protease ICH-3; Protease TY; TY; TY protease
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    37.8kDa
  • 表达区域：
    137-327aa
  • 氨基酸序列
    DQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
  • 基因功能参考文献：
    1. Long non-coding RNA CASP5 promotes the malignant phenotypes of human glioblastoma multiforme. PMID: 29715460
    2. Study shows that CASP5 was positively correlated with inflammation in rheumatoid arthritis (RA), and provides evidence that certain CASP5 SNPs were associated with an increased risk of RA. PMID: 29158166
    3. Th17 micro-milieu via IL-17A regulates NLRP1-dependent CASP5 activity in psoriatic skin autoinflammation. PMID: 28422993
    4. CASP5 gene overexpression significantly promoted angiogenesis ability of HMEC-1 cells, which was probably achieved by inhibiting angpt-1/Tie2 and promoting VEGF-1 signal pathway. PMID: 26884849
    5. The distribution of the other genotypes; rs507879, rs518604 and rs523104 of caspase-5) was not significantly different between patients with psoriasis vulgaris and the healthy controls. PMID: 25753570
    6. Data show that exposure of hepatocytes to direct hypoxia resulted in acid sphingomyelinase activation and ceramide elevation associated with activation of caspase 5 and the subsequent cleavage of HuR and apoptotic cell death. PMID: 22906436
    7. Mutual activation between caspase-5 and -1 suggests caspase-5 may work predominantly in concert with caspase-1 in modulating retinal pigment epithelium inflammatory responses. PMID: 21969293
    8. analysis of concerted antigen processing of a short viral antigen by human caspase-5 and -10 PMID: 21454616
    9. Caspase-5 and the inflammasome may have an important role in the inflammatory response in psoriasis. PMID: 21191419
    10. Unfavorable significance of CASP5 heterozygous genotype explained by its role in inflammation-related processes. PMID: 20434535
    11. Identification of caspase-5 coding region microsatellite mutations in vivo implicates this gene in the pathogenesis of human T-LBL/ALL PMID: 12479849
    12. Caspase-5 might be a suppressor gene of highly metastatic potential in lung cancer PMID: 12964016
    13. CASPASE-5, an acknowledged frameshift target in MSI+ gastrointestinal tract tumors, was frequently mutated in Microsatellite instability+ cell lines PMID: 15886296
    14. novel exon was present in six alternatively spliced caspase-5 mRNA variants expressed in human peripheral blood mononuclear cells (PBMC) and encoded the previously unknown amino-terminus of caspase-5. PMID: 16893518
    15. Caspase-5 gene is commonly mutated in the cancers with microsatellite instability suggesting that inactivation of caspase-5 may play a role in their tumorigenesis. PMID: 18430458
    16. Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer. PMID: 19203830
    17. Single nucleotide polymorphisms in CASP5 and RBBP8 gene are associated with survival in ovarian cancer patients. PMID: 19270026

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  • 蛋白家族：
    Peptidase C14A family
  • 组织特异性：
    Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.
  • 数据库链接：

    HGNC: 1506

    OMIM: 602665

    KEGG: hsa:838

    STRING: 9606.ENSP00000376849

    UniGene: Hs.213327