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  4. Recombinant Human COMM domain-containing protein 7 (COMMD7)

Recombinant Human COMM domain-containing protein 7 (COMMD7)

  • 货号：
    CSB-YP774817HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP774817HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP774817HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP774817HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP774817HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    COMMD7
  • Uniprot No.：
  • 别名：
    C20orf92; Chromosome 20 open reading frame 92; COMD7_HUMAN; COMM domain containing 7; COMM domain containing protein 7; COMM domain-containing protein 7; COMMD 7; COMMD7; dJ1085F17.3; FLJ14987; MGC33315; OTTHUMP00000030609
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-200
  • 氨基酸序列
    MGRLHCTEDP VPEAVGGDMQ QLNQLGAQQF SALTEVLFHF LTEPKEVERF LAQLSEFATT NQISLGSLRS IVKSLLLVPN GALKKSLTAK QVQADFITLG LSEEKATYFS EKWKQNAPTL ARWAIGQTLM INQLIDMEWK FGVTSGSSEL EKVGSIFLQL KLVVKKGNQT ENVYIELTLP QFYSFLHEME RVRTSMECFC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity.
  • 基因功能参考文献：
    1. COMMD7 activates CXCL10 production by regulating NFkappaB and the production of ROS. The present study highlighted the role of COMMD7 in the development of HCC, and provides novel options for anticancer drug design. PMID: 29532873
    2. COMMD7 up-regulation is correlated with a novel NF-kappaB positive feedback loop in hepatocellular carcinoma, regulation cell proliferation, cell migration and apoptosis. PMID: 27129158
    3. High COMMD7 expression was specifically detected in pancreatic ductal adenocarcinoma tissues and pancreatic ductal adenocarcinoma cell lines. In addition, COMMD7 overexpression positively correlated with histological differentiation and tumor node metastasis (TNM) stage. PMID: 27350032
    4. The present data suggests a potential role of CXCL10 in the oncogenic function of COMMD7. PMID: 28142122
    5. COMMD7's binding to NEMO does not interfere with the binding to the IKKs, and that the disruption of the IKK complex through the use of the NBP competitor impairs the termination of NF-kappaB activity PMID: 26060140
    6. COMMD7 contributes to hepatocellular carcinoma progression by reducing cell apoptosis and overcoming cell cycle arrest. PMID: 23049798
    7. BC047440 can promote the growth and invasion of hepatocellular carcinoma. PMID: 20979692

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  • 亚细胞定位：
    Cytoplasmic vesicle.
  • 组织特异性：
    Widely expressed with highest expression in lung.
  • 数据库链接：

    HGNC: 16223

    OMIM: 616703

    KEGG: hsa:149951

    STRING: 9606.ENSP00000278980

    UniGene: Hs.408427