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  4. Recombinant Human C2 calcium-dependent domain-containing protein 4B (C2CD4B)

Recombinant Human C2 calcium-dependent domain-containing protein 4B (C2CD4B)

  • 货号：
    CSB-YP008080HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008080HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008080HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008080HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008080HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    C2CD4B
  • Uniprot No.：
  • 别名：
    C2CD4B; FAM148B; NLF2; C2 calcium-dependent domain-containing protein 4B; Nuclear-localized factor 2; Protein FAM148B
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-364
  • 氨基酸序列
    MRLLEKLCSS AAGSSAPKPA FAKVLTPNRI PEFCIPPRLP APCTLESPIR AAAVPRRCAA ESDLWPRAAD EDAGRTDWDP RSQAALSLPH LPRVRTTYGF CALLESPHTR RKESLLLGGP PAPRPRAHSC GGGGGPDAPL GTLCGPRGPG PATPAAPGGP RLPQDALAAG PRRCRLLRVP DGLLSRALRA GRSRRLARVR SVSSGNEDEE RRAGSESPAR APSSSPLSSR APLPERLEAK GTVALGRAGD ALRLAAEYCP GTRRLRLRLL RAESLFGGAP GPRAVRCRLS LVLRPPGTAR WQCSAVVGRS RKASFDQDFC FDGLSEDEVR RLAVRVKARD EGRGRDRGRL LGQGELSLGA LLLL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in inflammatory process. May regulate cell architecture and adhesion.
  • 基因功能参考文献：
    1. rs7163757 contributes to genetic risk of islet dysfunction and type 2 diabetes by increasing NFAT-mediated islet enhancer activity and modulating C2CD4B, and possibly C2CD4A, expression in (patho)physiologic states. PMID: 29625024
    2. The present data thus provide evidence for a limited role for changes in VPS13C expression in conferring altered type 2 diabetes risk at this locus, particularly in females, and suggest that C2CD4A, but not C2CD4B, may also be involved. PMID: 27329800
    3. Loss of NLF2 gene expression in the endometrium of patients with implantation failure after in vitro ertilization treatment. PMID: 22885067
    4. Single nucleotide polymorphism in C2CD4B is associated with type 2 diabetes. PMID: 20818381
    5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20571754
    6. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20818381
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20419449
    8. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20081858
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 20185807
    10. NLF2 may play a role in regulating genes which control cellular architecture. PMID: 15527968

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    C2CD4 family
  • 组织特异性：
    Specifically expressed in endothelial cells.
  • 数据库链接：

    HGNC: 33628

    OMIM: 610344

    KEGG: hsa:388125

    STRING: 9606.ENSP00000369755

    UniGene: Hs.144372