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  4. Recombinant Human C-type lectin domain family 11 member A (CLEC11A)

Recombinant Human C-type lectin domain family 11 member A (CLEC11A)

  • 中文名称：
    Recombinant Human C-type lectin domain family 11 member A(CLEC11A),Yeast
  • 货号：
    CSB-YP896480HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human C-type lectin domain family 11 member A(CLEC11A),Yeast
  • 货号：
    CSB-EP896480HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human C-type lectin domain family 11 member A(CLEC11A),Yeast
  • 货号：
    CSB-EP896480HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human C-type lectin domain family 11 member A(CLEC11A),Yeast
  • 货号：
    CSB-BP896480HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human C-type lectin domain family 11 member A(CLEC11A),Yeast
  • 货号：
    CSB-MP896480HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CLEC11A
  • Uniprot No.：
  • 别名：
    C type (calcium dependent; carbohydrate recognition domain) lectin; superfamily member 3; C type lectin domain family 11 member A; C type lectin superfamily member 3; C-type lectin domain family 11 member A; C-type lectin superfamily member 3; CLC11_HUMAN; CLEC11A; CLECSF3; LSLCL; Lymphocyte secreted C type lectin; Lymphocyte secreted C-type lectin; lymphocyte secreted long form of C type lectin; p47; Stem cell growth factor; stem cell growth factor lymphocyte secreted C type lectin
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-323
  • 氨基酸序列
    ARGAEREWE GGWGGAQEEE REREALMLKH LQEALGLPAG RGDENPAGTV EGKEDWEMEE DQGEEEEEEA TPTPSSGPSP SPTPEDIVTY ILGRLAGLDA GLHQLHVRLH ALDTRVVELT QGLRQLRNAA GDTRDAVQAL QEAQGRAERE HGRLEGCLKG LRLGHKCFLL SRDFEAQAAA QARCTARGGS LAQPADRQQM EALTRYLRAA LAPYNWPVWL GVHDRRAEGL YLFENGQRVS FFAWHRSPRP ELGAQPSASP HPLSPDQPNG GTLENCVAQA SDDGSWWDHD CQRRLYYVCE FPF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone.
  • 基因功能参考文献：
    1. Clec11a maintains the adult skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts. PMID: 27976999
    2. Data show that asymptomatic patients with unstable plaques exhibited higher levels of endothelial microparticles (EMPs), CXCL9 chemokine and stem cell growth factor; lymphocyte secreted C-type lectin (SCGF-beta) compared to those with stable plaques. PMID: 26564003
    3. level of expression correlates with pain response in subjects with intervertebral disc disorders PMID: 26440592
    4. This is the first report of SCGF beta in heart failure patients. PMID: 23357302
    5. These studies highlight a possible role of SCGFalpha in imatinib-induced changes of gastrointestinal stromal tumors structure, consistent with a therapeutic response. PMID: 21943129
    6. The results presented here demonstrate that homozygous T at -539 in the SCGF promoter is associated with elevated SCGF production, enhanced erythropoiesis, and protection against severe malarial anemia. PMID: 19884328
    7. SCGF is selectively produced by osseous and hematopoietic stromal cells, and can mediate their proliferative activity on primitive hematopoietic progenitor cells. PMID: 11920266
    8. Results indicate that interleukin-4, together with recombinant human stem cell factor, can induce T cell maturation from cord blood progenitor cells, and that IL-4 increased the expression of FcepsilonRI on fetal liver mast cells. PMID: 14746805
    9. Human vascular smooth muscle cells express stem cell factor(SCF) and its receptor, c-kit. SCF is released from its membrane-bound form via MMP-9. SCF/c-kit signaling may affect SMC function via an autocrine pathway. PMID: 15234225
    10. phagocytosis of hemozoin promotes a decrease in SCGF gene products, which may contribute to reduced erythropoiesis in children with severe malarial anemia. PMID: 19528216

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  • 亚细胞定位：
    Cytoplasm. Secreted.
  • 组织特异性：
    Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.
  • 数据库链接：

    HGNC: 10576

    OMIM: 604713

    KEGG: hsa:6320

    STRING: 9606.ENSP00000250340

    UniGene: Hs.512680