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  4. Recombinant Human Beta-Ala-His dipeptidase (CNDP1)

Recombinant Human Beta-Ala-His dipeptidase (CNDP1)

  • 货号：
    CSB-YP836242HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP836242HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP836242HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP836242HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP836242HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CNDP1
  • Uniprot No.：
  • 别名：
    Beta Ala His dipeptidase; Beta-Ala-His dipeptidase; Carnosinase 1; Carnosinase1; Carnosine dipeptidase 1 (metallopeptidase M20 family); Carnosine dipeptidase 1; CN1; CNDP 1; CNDP dipeptidase 1; Cndp1; CNDP1_HUMAN; CPGL2; Glutamate carboxypeptidase like protein 2; Glutamate carboxypeptidase-like protein 2; HsT2308; MGC102737; MGC10825; MGC142072; OTTHUMP00000163751; Serum carnosinase; UNQ1915/PRO4380
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-507
  • 氨基酸序列
    SPSP PPALLEKVFQ YIDLHQDEFV QTLKEWVAIE SDSVQPVPRF RQELFRMMAV AADTLQRLGA RVASVDMGPQ QLPDGQSLPI PPIILAELGS DPTKGTVCFY GHLDVQPADR GDGWLTDPYV LTEVDGKLYG RGATDNKGPV LAWINAVSAF RALEQDLPVN IKFIIEGMEE AGSVALEELV EKEKDRFFSG VDYIVISDNL WISQRKPAIT YGTRGNSYFM VEVKCRDQDF HSGTFGGILH EPMADLVALL GSLVDSSGHI LVPGIYDEVV PLTEEEINTY KAIHLDLEEY RNSSRVEKFL FDTKEEILMH LWRYPSLSIH GIEGAFDEPG TKTVIPGRVI GKFSIRLVPH MNVSAVEKQV TRHLEDVFSK RNSSNKMVVS MTLGLHPWIA NIDDTQYLAA KRAIRTVFGT EPDMIRDGST IPIAKMFQEI VHKSVVLIPL GAVDDGEHSQ NEKINRWNYI EGTKLFAAFF LEMAQLH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-3-methyl-histidine).
  • 基因功能参考文献：
    1. The distribution of the (CTG)5 homozygous genotype in the no-diabetic nephropathy (DN) and clinical-DN patients was comparable, a lower frequency was found in the biopsy proven-DN patients, particularly in females. We observed a significant trend towards high frequencies of the (CTG)5 homozygous genotype with increased time on dialysis. PMID: 28553654
    2. Considering that approximately 40 per cent of the population are homozygous for the 5L allele of (CTG) n repeat polymorphism in CNDP1 gene and seem to be less prone to develop DN, it is needed to evaluate whether the majority of diabetic patients (who do not have the 5L-5L genotype) would be benefited from supplementation with carnosine or with a more intensive monitoring PMID: 27834319
    3. Compared to healthy individuals and those with diabetes but no kidney disease, patients with diabetic nephropathy exhibited lower frequencies of 5L-5L genotype and 5L allele of CNDP1 gene, suggesting that this allele might confer protection against development of kidney disease in this population. PMID: 27834323
    4. genetic association studies in pediatric population in Germany: Data suggest that, in pediatric patients with chronic kidney disease, the nephroprotective effect of CNDP1 Mannheim genetic variant against disease progression is not restricted to patients with diabetic nephropathy. PMID: 27278783
    5. The experimentally measured higher affinity of homocarnosine for the enzyme relative to l-carnosine might be explained, at least in part, by more extensive interactions inside the monomeric and dimeric hCN1's active site. PMID: 27105448
    6. Data shows that higher carnosine content in human skeletal muscle is positively associated with insulin resistance and fasting metabolic preference for glucose. PMID: 26439389
    7. In gastrointestinal cancer, reduced plasma levels of CNDP1 associate with signs of catabolism and poor outcome. PMID: 25898255
    8. Alterations of serum carnosinase (CN1) activity has been associated with several pathological conditions, such as neurological disorders, chronic diseases and cancer PMID: 24566305
    9. This meta-analysis confirms that the carnosinase D18S880 microsatellite polymorphism is associated with daibetic nephropathy susceptibility, especially in the type 2 DM and the Caucasian population. PMID: 23402577
    10. Rs12604675-A in CNDP1 may confer susceptibility to overt proteinuria in Japanese women with type 2 diabetes. PMID: 23342076
    11. In this review, correlations between serum carnosine and carnosinase activity and polymorphism in CNDP1 gene are analyzed. The role of CNDP1 gene polymorphism the development of diabetic nephropathy and non-diabetic chronic kidney disease is discussed. PMID: 22706107
    12. Plasma levels of FLT and S100A9 proteins are up-regulated and CNDP1 levels are down-regulated in patients with glioblastoma. PMID: 23029420
    13. These findings provide nominal evidence supporting a role between CNDP1 variants and diabetic kidney disease. PMID: 21393041
    14. neither CNDP1 genotype nor the normal variation in circulating testosterone levels affects the muscular carnosine content PMID: 20865290
    15. Serum histidine dipeptide concentrations are not correlated to serum carnosinase activity PMID: 20971102
    16. CNDP1 polymorphism predicts progression to ESRD in patients with diabetic nephropathies, but only late after baseline measurements. PMID: 20711718
    17. CTG polymorphism of the CNDP1 gene does not affect survival of Chinese peritoneal dialysis subjects. PMID: 20979941
    18. Hyperglycemia enhances CNDP1 secretion and enzyme activity; data suggest that poor blood glucose control in diabetic patients might result in an increased enzyme secretion even in the presence of the (CTG)(5) allele. PMID: 20460427
    19. Association between the CNDP1 gene and diabetic nephropathy is sex specific and independent of susceptibility for type 2 diabetes. PMID: 20332346
    20. GCP II mRNA was detected in glial cells. Glial-rich regions, specifically the DLPFC and ERC white matter and the molecular and polymorphic layers in the hippocampus, express high levels of GCP II mRNA. PMID: 14560319
    21. diabetic patients with the carnosinase CNDP1 gene Mannheim variant are less susceptible for nephropathy PMID: 16046297
    22. no difference in allele or genotype frequency between centenarians & controls or between cardiovascular patients & controls; the recently identified functional carnosinase variant does not contribute to longevity or protect against coronary heart disease PMID: 16965804
    23. CPGL-B may be associated with cell growth and metastasis of HCC. PMID: 17121880
    24. This replicates the CNDP1 gene association with diabetic nephropathy (DN) that was initially detected in European Caucasians and in Arabs, and further demonstrates that the CNDP1 gene and carnosine pathway appear to play a role in susceptibility to DN. PMID: 17205963
    25. Diabetic patients homozygous for CNDP1 are protected against diabetic nephropathy. PMID: 17601991
    26. CN1-dependent susceptibility to diabetic nephropathy may at least in part be mediated by altered glucose metabolism in type 2 diabetic patients. PMID: 17601992
    27. South Asian Surinamese have a lower frequency of the 5/5 homozygous genotype, which was associated with lower carnosinase activity and genetic risk for developing diabetic nephropathy. PMID: 19577318

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M20A family
  • 组织特异性：
    Found in serum and adult nervous central system. Absent in serum from patients with homocarnosinosis.
  • 数据库链接：

    HGNC: 20675

    OMIM: 609064

    KEGG: hsa:84735

    STRING: 9606.ENSP00000351682

    UniGene: Hs.400613