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  4. Recombinant Human Beta-2-glycoprotein 1 (APOH)

Recombinant Human Beta-2-glycoprotein 1 (APOH)

  • 货号：
    CSB-YP001939HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001939HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001939HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001939HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001939HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Activated protein C binding protein; Activated protein C-binding protein; Anticardiolipin cofactor; APC inhibitor; Apo-H; APOH; APOH_HUMAN; apolipoprotein H (beta-2-glycoprotein I); Apolipoprotein H; B2G1; B2GP1; B2GPI; Beta 2 glycoprotein I; Beta 2 glycoprotein I precursor; Beta(2)GPI; Beta-2-glycoprotein 1; Beta-2-glycoprotein I; BG; Glycoprotein 1; beta-2; Glycoprotein I; beta-2; OTTMUSP00000003033
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-345
  • 氨基酸序列
    G RTCPKPDDLP FSTVVPLKTF YEPGEEITYS CKPGYVSRGG MRKFICPLTG LWPINTLKCT PRVCPFAGIL ENGAVRYTTF EYPNTISFSC NTGFYLNGAD SAKCTEEGKW SPELPVCAPI ICPPPSIPTF ATLRVYKPSA GNNSLYRDTA VFECLPQHAM FGNDTITCTT HGNWTKLPEC REVKCPFPSR PDNGFVNYPA KPTLYYKDKA TFGCHDGYSL DGPEEIECTK LGNWSAMPSC KASCKVPVKK ATVVYQGERV KIQEKFKNGM LHGDKVSFFC KNKEKKCSYT EDAQCIDGTI EVPKCFKEHS SLAFWKTDAS DVKPC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
  • 基因功能参考文献：
    1. This study aimed to explore the mechanism of a novel mutation (p.Lys38Glu) in apolipoprotein H (APOH) gene causing hereditary beta2-glycoprotein I (beta2GPI) deficiency and thrombosis in a proband with thrombophilia. PMID: 30074200
    2. Data suggest alpha-1-antitrypsin (A1AT) and APOH (beta-2-glycoprotein-1) could represent promising markers for renal carcinogenesis in Von Hippel-Lindau disease (VHLD) patients. PMID: 28004973
    3. Suggest that anti-beta2 GPI antibodies bind to beta2 GPI-PS complexes expressed on microparticles. Consequent loss of beta2 GPI-PS expression on MPs may impair scavenging and contribute to the accumulation of circulating PS-negative MPs, a possible source of autoantigens in systemic lupus erythematosus. PMID: 28667788
    4. the data revealed that reduced beta2GPI exerts protective effects from glucoseinduced injury in human umbilical cord vein endothelial cells. PMID: 28731130
    5. Data suggest that, in patients with anti-GPIIb/IIIa-mediated immune thrombocytopenia, diminished plasma levels of beta2-GPI are linked to enhanced complement activation. PMID: 29350259
    6. The aim of this study was to assess clinical utility of the anti-Domain 1 B2GP1 antibodies in the diagnosis and risk stratification of antiphospholipid syndrome. Anti-Domain 1 test does not add accuracy in predicting Antiphospholipid syndrome thrombotic complications on the top of accuracy offered by classic tests. PMID: 28363116
    7. we have demonstrated a pathogenic role for aPL containing samples, mediated via aPL-2bGPI interactions, resulting in activation of the pro-apoptotic p38 MAPK pathway. PMID: 28079888
    8. Pretransplant IgA-aB2GP1 was the main risk factor for graft thrombosis and early graft loss after renal transplantation. PMID: 27140515
    9. These results suggest that antibodies directed against domain 1 of beta-2-glycoprotein 1 may contribute to antiphospholipid syndrome risk assessment, due to their association with the diagnosis of systemic autoimmunity and with more aggressive triple antiphospholipid antibody profiles, such as triple positivity and lupus anticoagulant activity. PMID: 27770664
    10. Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein are Strongly Associated with the Occurrence of Acute Thrombotic Events. PMID: 27063992
    11. Genome-wide significant results in or near the APOH gene on chromosome 17 have been found for plasma apolipoprotein H levels in middle-aged and older adults. PMID: 27030319
    12. Prevalence and pathogenicity of IgA aB2GPI antibodies may vary from a population of ESRD patients to another. PMID: 26900811
    13. The association of IL28B and APOH single nucleotide polymorphisms (SNPs) with sustained virological response and of ITPA SNPs with anemia related phenotypes. PMID: 26670100
    14. We identified APOH as an obesity-resistance gene that interacts with FTO rs9939609 to more than double the occurrence of thinness. PMID: 26711810
    15. Trp316Ser variant (rs1801690) near the apolipoprotein H (beta2-glycoprotein-I) gene was associated with serum lipid parameters in Chinese volunteers. Suggest that there may be have racial/ethnic-and/or gender-specificity. PMID: 26261630
    16. Using affinity chromatography, polymyxin B can effectively decrease the binding of beta2GP1 to immobilize phosphatidylserine. PMID: 24275099
    17. Plasma apolipoprotein H limits HCV replication and associates with response to NS3 protease inhibitor-based therapy. PMID: 25556540
    18. The renoprotective and antifibrosis effects of beta2GPI and reduced beta2GPI on diabetic nephropathy were closely associated with suppressing the activation of the TGF-beta1-p38 MAPK pathway. PMID: 26045739
    19. Apo H is up-regulated in aspirin-tolerant asthma (ATA) compared to aspirin-exacerbated respiratory disease (AERD) and normal controls, suggesting that Apo H may be involved in different pathogenesis of ATA from AERD PMID: 24120690
    20. the V/V genotype and the V-encoding allele at position 247 of the beta2GPI gene had strong correlation with the occurrence of thrombosis and the production of the anti-beta2GPI antibodies. PMID: 24661363
    21. Apolipoprotein H expression is associated with IL28B Single Nucleotide Polymorphism and viral clearance in hepatitis C virus infection. PMID: 24905490
    22. The interaction between beta2GPI and TLR4 is confirmed by the reduction of anti-beta2GPI antibody binding and by the up-regulation of E-selectin or ICAM-1 by TLR4 silencing in HUVEC. PMID: 24685231
    23. APOH is a new candidate gene associated with thrombosis PMID: 25081279
    24. Data indicate that subjects with xidized low-density lipoprotein/beta2-glycoprotein I (oxLDL/beta2GPI) above the median (0.25 U/mL) were more likely to have arterial or venous disease. PMID: 25405208
    25. Serum from peripheral arterial disease patients with elevated beta2 glycoprotein I antibodies induces a genomic overexpression of TLR4 and its cellular signalling molecules in endothelial cells. PMID: 24472415
    26. Pretransplant IgA-aB2GPI-ab may have a detrimental effect on early clinical outcomes after renal transplantation. PMID: 25071084
    27. Partial or complete removal of the carbohydrate chains uncover cryptic epitopes present in beta(2)GPI. PMID: 25256745
    28. Serum beta2-GPI-Lp(a) levels were increased in ischemic stroke patients PMID: 24315780
    29. beta(2) GPI functions as a physiologic anticoagulant by inhibiting the key procoagulant activities of thrombin without affecting its unique anticoagulant function PMID: 23578283
    30. In seeking to identify proteins phosphorylated during anti-beta2GPI antibody-induced endothelial activation, we observed phosphorylation of nonmuscle myosin II regulatory light chain (RLC), which regulates cytoskeletal assembly. PMID: 23954892
    31. beta2GPI is a major autoantigen in the antiphospholipid syndrome; this protein can bind to the surface of apoptotic cells, playing a dual role as immunogen and as pathophysiological target of antiphospholipids. PMID: 23713583
    32. Both NF-kappaB and c-Jun/AP-1 can be activated and play important roles in the process of anti-beta2GPI/beta2GPI-induced tissue factor expression in monocytes. PMID: 23467542
    33. IgA antibodies to beta-glycoprotein I are detrimental to the clinical outcome of hemodialysis patients. PMID: 22358146
    34. Identify common variants reflecting the genetic architecture influencing plasma beta2 -GPI levels. PMID: 23279374
    35. This review discusses the characteristics of beta2GPI, an antigen of central importance in antiphospholipid syndrome (APS), as well as the targeting of the beta2GPI/anti-beta2GPI interaction in the treatment of APS. PMID: 23692565
    36. Beta(2)-GPI plays an essential role in the down-regulation of VEGF-induced endothelial responses. PMID: 22956423
    37. MAPKs (p38, ERK1/2 and JNK1/2) were the crucial downstream targets of the anti-beta(2)GPI/beta(2)GPI -triggered TLR4 signaling pathways in THP-1 cells. PMID: 22940059
    38. anti-beta(2)GPI/beta(2)GPI complex induced TF and TNF-alpha expression involving both TLR4/MyD88 and TLR4/TRIF signaling pathways and TLR4 and its adaptors might be molecular targets for therapy of antiphospholipid syndrome PMID: 22964479
    39. anti-oxLDL-beta2GPI antibodies and IgM anti-Elevated oxLDL-beta2GPI antibodies were detected in systemic lupus erythematosus, which may contribute to the elevated cardiovascular risk in SLE patients. PMID: 23214196
    40. Findings support the notion that the beta2-glycoprotein I (beta2GPI) Valine/Leucine247 polymorphism plays a role, but is probably not crucial in the pathogenesis of anti-phospholipid syndrome influencing development of anti-beta2GPI and thrombosis. PMID: 22399073
    41. Recent developments in our understanding of the antiphospholipid syndrome. (review) PMID: 22394675
    42. [review] Val/Val genotype of beta2-GPI gene is associated with antiphospholipid syndrome (APS), by patients with APS, with production of anti-beta2-GPI antibodies. PMID: 22246055
    43. epitope glycine40-arginine43 of domain I of beta2GPI predominantly responsible for binding thrombosis related antibodies [review] PMID: 22635228
    44. immunocomplexes of Hep, beta2GPI and anti-beta2GPI IgG in plasma of patients with antiphospholipid syndrome PMID: 22635233
    45. among Spanish Caucasians, polymorphisms at codon 247 (Val247Leu) do not seem to influence primary antiphospholipid syndrome pathogenesis. PMID: 21240499
    46. Letter: report breast cancer patient with elevated anti-beta2-glycoprotein I antibody and cerebellar ataxia. PMID: 22427365
    47. Increased complexes of beta(2)-glycoprotein I with lipoprotein(a)is associated with coronary artery disease. PMID: 22056596
    48. A review of the role of oxidative stress in beta2-GPI-mediated immune responses. PMID: 21999151
    49. [REVIEW] function in innate immunity; function of beta(2) -GPI seems to depend on the structural conformation of the protein PMID: 21535391
    50. role of beta2-GPI in placentation: Data suggest that in some women with habitual miscarriage, antagonism of beta2-GPI by autoantibodies against beta2-GPI suppresses PlGF production in trophoblasts and causes failure of placenta formation/function. PMID: 21501325

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed by the liver and secreted in plasma.
  • 数据库链接：

    HGNC: 616

    OMIM: 138700

    KEGG: hsa:350

    STRING: 9606.ENSP00000205948

    UniGene: Hs.445358