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  4. Recombinant Human B-cell CLL/lymphoma 6 member B protein (BCL6B)

Recombinant Human B-cell CLL/lymphoma 6 member B protein (BCL6B)

  • 中文名称：
    Recombinant Human B-cell CLL/lymphoma 6 member B protein(BCL6B),Yeast
  • 货号：
    CSB-YP818679HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human B-cell CLL/lymphoma 6 member B protein(BCL6B),Yeast
  • 货号：
    CSB-EP818679HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human B-cell CLL/lymphoma 6 member B protein(BCL6B),Yeast
  • 货号：
    CSB-EP818679HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human B-cell CLL/lymphoma 6 member B protein(BCL6B),Yeast
  • 货号：
    CSB-BP818679HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human B-cell CLL/lymphoma 6 member B protein(BCL6B),Yeast
  • 货号：
    CSB-MP818679HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BCL6B
  • Uniprot No.：
  • 别名：
    BCL6B; BAZF; ZNF62B-cell CLL/lymphoma 6 member B protein; Bcl6-associated zinc finger protein; Zinc finger protein 62
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-479
  • 氨基酸序列
    MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPLEAEPP TPPTAPPPGS PRRSEGHPDP PTESRSCSQG PPSPASPDPK ACNWKKYKYI VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS SSSSEEGPIP GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH TGEKPYHCSI CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR AHVLIHTGEK PYPCPTCGTR FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR HKSQLRLHLR QKHGAATNTK VHYHILGGP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.
  • 基因功能参考文献：
    1. BCL6B suppressed the proliferation and migration of colorectal carcinoma cells cells indirectly, via inhibition of PI3K. PMID: 29393377
    2. BCL6B plays a pivotal role as a prognostic biomarker for HCC. PMID: 25970780
    3. Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cells to become resistant to 5-FU. PMID: 25909168
    4. BCL6B functions as a tumor suppressor that inhibits HCC metastases in vitro and in vivo. PMID: 25218345
    5. Patients with three or more methylated CpG sites in the BCL6B promoter were significantly associated with poor survival. PMID: 25008234
    6. BCL6B methylation may serve as a novel potential non-invasive plasma biomarker for the detection of gastric cancer PMID: 24191714
    7. BCL6B plays a pivotal role as a potential tumour suppressor in GC. Detection of methylated BCL6B may serve as an independent biomarker for the prognosis of GC. PMID: 21917650

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitously expressed with higher expression found in heart and placenta.
  • 数据库链接：

    HGNC: 1002

    OMIM: 608992

    KEGG: hsa:255877

    STRING: 9606.ENSP00000293805

    UniGene: Hs.22575