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  4. Recombinant Human Autophagy-related protein 16-2 (ATG16L2)

Recombinant Human Autophagy-related protein 16-2 (ATG16L2)

  • 货号：
    CSB-YP843310HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP843310HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP843310HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP843310HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP843310HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    A16L2_HUMAN; APG16-like 2; ATG16 autophagy related 16-like 2; ATG16B; Atg16l2; autophagy related 16-like 2 (S. cerevisiae); Autophagy-related protein 16-2; WD repeat-containing protein 80; WDR80
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-619
  • 氨基酸序列
    MAGPGVPGAP AARWKRHIVR QLRLRDRTQK ALFLELVPAY NHLLEKAELL DKFSKKLQPE PNSVTPTTHQ GPWEESELDS DQVPSLVALR VKWQEEEEGL RLVCGEMAYQ VVEKGAALGT LESELQQRQS RLAALEARVA QLREARAQQA QQVEEWRAQN AVQRAAYEAL RAHVGLREAA LRRLQEEARD LLERLVQRKA RAAAERNLRN ERRERAKQAR VSQELKKAAK RTVSISEGPD TLGDGMRERR ETLALAPEPE PLEKEACEKW KRPFRSASAT SLTLSHCVDV VKGLLDFKKR RGHSIGGAPE QRYQIIPVCV AARLPTRAQD VLDAHLSEVN AVRFGPNSSL LATGGADRLI HLWNVVGSRL EANQTLEGAG GSITSVDFDP SGYQVLAATY NQAAQLWKVG EAQSKETLSG HKDKVTAAKF KLTRHQAVTG SRDRTVKEWD LGRAYCSRTI NVLSYCNDVV CGDHIIISGH NDQKIRFWDS RGPHCTQVIP VQGRVTSLSL SHDQLHLLSC SRDNTLKVID LRVSNIRQVF RADGFKCGSD WTKAVFSPDR SYALAGSCDG ALYIWDVDTG KLESRLQGPH CAAVNAVAWC YSGSHMVSVD QGRKVVLWQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner.
  • 基因功能参考文献：
    1. ATG16L2 is a susceptibility gene for Crohn's disease in the Chinese population. The rs11235604 single nucleotide polymorphism is remarkably associated with downregulation of the expression of ATG16L2. PMID: 27611316
    2. A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2. PMID: 26663301
    3. Atg16L2 may play an important role in autophagy of T cells and serve as a potential biomarker to predict clinical relapse of Multiple sclerosis PMID: 24406150
    4. Three novel risk loci including ATG16L2 were discovered by genome-wide association study in the Korean Crohn's disease population, of which two showed patterns of association in the International Inflammatory Bowel Disease Genetics Consortium dataset. PMID: 23850713
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    WD repeat ATG16 family
  • 数据库链接：

    HGNC: 25464

    KEGG: hsa:89849

    STRING: 9606.ENSP00000326340

    UniGene: Hs.653186