Recombinant Human Autophagy-related protein 16-1 (ATG16L1)

1. genetic associations studies conducted in population of postmenopausal women in Brazil: Data suggest that a genetic polymorphism in ATG16L1 (T300A) is associated with cardiovascular disease in postmenopausal women in the population studied (after adjustments for confounding variables). PMID: 30236831
2. show that the WD repeat-containing C-terminal domain (WD40 CTD) of ATG16L1 is essential for LC3 recruitment to endolysosomal membranes during non-canonical autophagy PMID: 29317426
3. the role of the autophagy elongation complex (ATG5-12/16L1) in Hepatitis C virus replication and membranous web formation, was examined. PMID: 28067309
4. The association of ATG16L1 to Crohn's disease in Iranian patients was confirmed while it was shown that the studied polymorphisms in IRGM was not associated with Crohn's disease. PMID: 29960072
5. T300A polymorphism alters the function of motif-containing molecules that engage ATG16L1 through the WD40 domain PMID: 27273576
6. Two SNPs (rs4663421 and rs6758317) and the TT haplotype of the ATG16L1 gene are possibly associated with ankylosing spondylitis susceptibility in a Chinese Han female population. PMID: 28952203
7. the ATG16L1 genotype was significantly associated with the risk of developing Crohn's disease. PMID: 27698206
8. The identification, purification, biochemical characterization and crystallization of the proteolytically stable ATG16L1 subfragment, 72-307, are reported here. PMID: 28994404
9. Our results suggest that these three genes that are critical components of the autophagy pathway (ATG16L, ATG2B, ATG5) are not significant risk factors among Spanish patients with either pseudoexfoliation syndrome or pseudoexfoliation glaucoma. PMID: 27960588
10. TMEM74 promotes tumor cell survival by inducing autophagy via interactions with ATG16L1 and ATG9A. PMID: 29048433
11. HBV gained access to Atg5-12/16L1 via interaction of its core protein with the Atg12 moiety of the complex. In contrast, subsequent autophagosome maturation and closure events were unnecessary for HBV replication, as evidenced by inhibition of Atg8/LC3 conjugation. Interfering with the HBV/Atg12 cross talk may be a tool for virus control. PMID: 29367244
12. genetic variations in ATG16L1 can predict brain metastasis (BM) and that genome analysis would facilitate stratification of patients for BM prevention trials. PMID: 28441070
13. transient expression of ATG16L1 not only inhibited autophagosome biogenesis, but also aberrantly targeted RAB11-positive recycling endosomes, resulting in recycling endosome aggregates. PMID: 27875067
14. the ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants PMID: 27893720
15. this study shows that the association between ATG16L1 and Crohn's disease is mediated at least in part through Rac1 hyperactivation and subsequent defective dendritic cell migration PMID: 27435106
16. the data suggested that genetic variants within the ATG16L1 gene promoter were not a risk factor for sporadic Parkinson's disease development PMID: 28279708
17. Polymorphism in ATG16L1 gene is associated withinflammatory bowel disease. PMID: 28542425
18. EVA1A interacts with the WD repeats of ATG16L1 through its C-terminal and promotes ATG12-ATG5/ATG16L1 complex recruitment to the autophagic membrane and enhances the formation of the autophagosome. PMID: 27490928
19. Identified and present structure of the predicted WD40 domain boundaries of the autophagy-related protein 16-1 (ATG16L1). PMID: 28685931
20. this study revealed that ATG16L1 deficiency led to alterations in macrophage function that contribute to the severity of Crohn disease PMID: 28130498
21. The present results support the hypothesis that Trimethylamine N-oxide may be involved in the pathogenesis of inflammatory bowel disease by impacting ATG16L1-induced autophagy and activating NLRP3 inflammasome. PMID: 28629999
22. MicroRNA-410 regulates autophagy-related gene ATG16L1 expression and enhances chemosensitivity via autophagy inhibition in osteosarcoma.( PMID: 28138700
23. we focus on the contributions of the plasma membrane to autophagosome biogenesis governed by ATG16L1 and ATG9A trafficking, and summarize the physiological and pathological implications of this macroautophagy route, from development and stem cell fate to neurodegeneration and cancer. PMID: 27758042
24. ATG16L1 T300A Polymorphism is Correlated with Gastric Cancer Susceptibility. PMID: 26547861
25. Induction of Anti-TNF induced macrophages is impaired in donors carrying the T300A risk allele for the ATG16L1 suggesting that an intact autophagy pathway may be important for an optimal response to anti-TNF therapy in inflammatory bowel disease. PMID: 26417049
26. The Egr-1 and Atg16L1 genes' polymorphisms were significant risk factors for susceptibility to chronic obstructive pulmonary disease (COPD) . These results demonstrate that autophagy regulator genetic mutations are associated with COPD in male smokers. PMID: 24012056
27. Subjects homozygous for the autophagy-related 16-like protein (ATG16L1) CD-associated gene variant (rs2241880), had low SHIP mRNA expression and activity. PMID: 26226011
28. The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. PMID: 25645662
29. ATG16L1 as a bona fide physiological CSNK2 and PPP1 substrate, which reveals a novel molecular link from CSNK2 to activation of the autophagy-specific ATG12-ATG5-ATG16L1 complex and autophagy induction PMID: 26083323
30. Knockdown of Atg16L1, a crucial autophagy gene, leads to developmental retention of early-stage cells in various tissues where the differentiation of stem cells is retarded. PMID: 26837467
31. Antibacterial autophagy is impaired in CLEC12A-deficient cells, and this effect is exacerbated in the presence of the ATG16L1( *)300A risk allele. PMID: 26095365
32. ATG16L1 may be used as a biomarker for selecting oral squamous cell carcinoma patients with a more aggressive phenotype. PMID: 25060858
33. CNTNAP3 could upregulate the expression of ATG16L1 and increase autophagy vacuoles PMID: 25883416
34. decreased expression in colon biopsies of Crohn's disease patients; conversely, increased expression in ulcerative colitis patients PMID: 25886994
35. ATG16L1 variant rs2241880 was associated with 38% increase in the risk for Crohn's disease for higher mutational load, whereas IL23R variant rs11209026 decreased the risk by 54% for higher mutational load. PMID: 25738374
36. CD patients homozygous for the ATG16L1-T300A risk allele show impaired clearance of pathosymbionts in ileal inflammation indicating that ATG16L1 is essential for effective elimination of pathosymbionts upon inflammation. PMID: 25253126
37. genotyped 31 Crohn's disease (CD)-associated genes in 102 Slovenian patients. The strongest association for treatment response defined as decrease in CRP levels was found for ATG16L1 SNP rs10210302. PMID: 25712183
38. These two steps are essential for the maturation of small single-membrane autophagic precursors containing ATG16L1 and mATG9 proteins into double-membrane autophagosomes PMID: 25461811
39. The signaling axis of HIF-1a, miR-20a-5p, and ATG16L1 in autophagic process might be a critical adapting mechanism for ischemic kidney injury. PMID: 26165754
40. ATG16L1 gene does play a role in the pathogenesis of Crohn's Disease in the Chinese population. PMID: 25048429
41. ATG16L1 expression could influence vascular endothelial function during atherogenesis. PMID: 25767270
42. Data suggest ATG16L1 dimer interacts with WIPI2b (WD repeat domain phosphoinositide-interacting protein 2) and this interaction is linked to phosphatidylinositol 3-phosphate production in endoplasmic reticulum and autophagosome formation. [REVIEW] PMID: 25233411
43. results showed that the prevalence of ATG16L1 and IL23R variants was not significantly different between patients and controls. However a possible role of ATG16L1 (T300A) on CD phenotype was suggested PMID: 25159710
44. Subjects carrying GG genotype were at a higher risk for colorectal cancer (OR 1.99, 95% CI: 1.02-3.91, p=0.039) when compared with the more frequent AA genotype. PMID: 24715166
45. Monocytes of Crohn's disease patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants. PMID: 24627602
46. MIR142-3p, upon transient overexpression in the cells, resulted in decreased ATG16L1 mRNA and protein levels PMID: 24401604
47. Carriage of the minor A allele of ATG16L1 was associated with septic shock with at least one organ failure (odds ratio (OR): 2.40, p: 0.036). PMID: 24791954
48. this is the first paediatric study reporting an association between the presence of the rs2241880 risk polymorphism of ATG16L1 in children with CD and a more severe phenotype of the disease. PMID: 24656308
49. The frequency of the allele G of the polymorphism T300A was higher in the group of patients with Crohn's disease (48.6%) than in controls (42.4%), although not reaching statistical significance. PMID: 25003259
50. Letter: ATG16L1 rs2241880 genetic polymorphism does not confer predisposition to rheumatoid arthritis. PMID: 23535819

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HGNC: 21498

OMIM: 610767

KEGG: hsa:55054

STRING: 9606.ENSP00000375872

UniGene: Hs.529322