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  4. Recombinant Human Aurora kinase A-interacting protein (AURKAIP1)

Recombinant Human Aurora kinase A-interacting protein (AURKAIP1)

  • 中文名称：
    Recombinant Human Aurora kinase A-interacting protein(AURKAIP1),Yeast
  • 货号：
    CSB-YP889131HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Aurora kinase A-interacting protein(AURKAIP1),Yeast
  • 货号：
    CSB-EP889131HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Aurora kinase A-interacting protein(AURKAIP1),Yeast
  • 货号：
    CSB-EP889131HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Aurora kinase A-interacting protein(AURKAIP1),Yeast
  • 货号：
    CSB-BP889131HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Aurora kinase A-interacting protein(AURKAIP1),Yeast
  • 货号：
    CSB-MP889131HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    AURKAIP1
  • Uniprot No.：
  • 别名：
    28S ribosomal protein S38; AIP; AKIP_HUMAN; AURKA interacting protein; AURKA-interacting protein; AURKAIP 1; Aurkaip1; Aurora A kinase interacting protein; Aurora kinase A interacting protein 1; Aurora kinase A-interacting protein; FLJ20608; mitochondrial; MRP-S38
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-199
  • 氨基酸序列
    MLLGRLTSQL LRAVPWAGGR PPWPVSGVLG SRVCGPLYST SPAGPGRAAS LPRKGAQLEL EEMLVPRKMS VSPLESWLTA RCFLPRLDTG TAGTVAPPQS YQCPPSQIGE GAEQGDEGVA DAPQIQCKNV LKIRRRKMNH HKYRKLVKKT RFLRRKVQEG RLRRKQIKFE KDLRRIWLKA GLKEAPEGWQ TPKIYLRGK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
  • 基因功能参考文献：
    1. Encodes a mitochondrial protein PMID: 22356826
    2. Aurora-A protein increased in stomach cancer cells in response to cisplatin and was degraded upon combined treatment with capsaicin with cisplatin. PMID: 21932983
    3. Results describe the identification of a novel negative regulator of Aurora-A, named AIP (Aurora-A kinase Interacting Protein). PMID: 12244051
    4. Phe31Ile polymorphism in Aurora A may be a genetic modifier for developing breast carcinoma. PMID: 15271856
    5. We propose that AURKAIP1 might function upstream of the Az1 by enhancing the binding affinity of Az1 to Aurora-A to promote recognition, targeting to proteasome and subsequent degradation. PMID: 17452972
    6. AKURA phosphorylation of AIP and stabilization of the enzyme-substrate complex are reported. PMID: 17957726
    7. GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP. PMID: 18391981
    8. Plk1 controls Aurora A localization and function by regulating cellular levels of hBora. PMID: 18521620
    9. Aurora A is necessary for the maintenance of the mitotic delay induced in response to microtubule-perturbing agents. PMID: 19221504

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  • 亚细胞定位：
    Mitochondrion. Nucleus.
  • 蛋白家族：
    Mitochondrion-specific ribosomal protein mS38 family
  • 组织特异性：
    Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.
  • 数据库链接：

    HGNC: 24114

    OMIM: 609183

    KEGG: hsa:54998

    STRING: 9606.ENSP00000319778

    UniGene: Hs.632515