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  4. Recombinant Human Anion exchange protein 2 (SLC4A2), partial

Recombinant Human Anion exchange protein 2 (SLC4A2), partial

  • 货号：
    CSB-YP021667HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021667HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021667HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021667HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021667HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC4A2
  • Uniprot No.：
  • 别名：
    AE 2; AE2 anion exchanger; Anion exchange protein 2; Anion exchanger 2; B3A2_HUMAN; BAND 3-LIKE PROTEIN; BND3L; EPB3L1; erythrocyte band 3; Erythrocyte membrane protein band 3 like 1; HKB3; MPB3L; NBND3; Non-erythroid band 3-like protein; Slc4a2; Solute carrier family 4 member 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plasma membrane anion exchange protein of wide distribution.
  • 基因功能参考文献：
    1. The regulation of a basolateral located, DIDS-sensitive, Cl(-)/HCO3(-) exchanger, anion exchanger 2 (AE2; SLC4A2) which is postulated to act as an acid loader, and therefore potential regulator of HCO3(-) secretion, in human airway epithelial cells. PMID: 28455748
    2. To match the stimulatory effect on acid uptake, cell-to-cell coupling in NHDF-Ad and CCD-112-CoN cells was strengthened with TGFbeta1.Importantly, the activities of stromal AE2 and connexin-43 do not place an energetic burden on cancer cells, allowing resources to be diverted for other activities PMID: 27543333
    3. ABA transport in human nucleated cells occurs via the anion exchanger AE2 PMID: 27015766
    4. down-regulation in primary biliary cholangitis sensitizes cholangiocytes to apoptotic insults by activating soluble adenylyl cyclase PMID: 26991014
    5. regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity PMID: 26716707
    6. AE2 is a major pathway for basolateral Cl(-) loading during cAMP-stimulated secretion of Cl(-) and fluid by Calu-3 cells PMID: 22802585
    7. A novel signal pathway involved in gastrin-stimulated AE2 expression mediated by EGR1 in gastric cancer cells. PMID: 23121767
    8. miR-506 is up-regulated in primary biliary cirrhosis, binds the 3'UTR region of AE2 mRNA, and prevents protein translation, leading to diminished AE2 activity and impaired biliary secretory functions. PMID: 22383162
    9. CTLA4 and SLC4A2 genetic polymorphisms are differentially associated with primary biliary cirrhosis development and progression, as well as anti-gp210 or anti-centromere antibody production, in Japanese PBC patients PMID: 21594562
    10. Dysfunctions related to AE2 might have a role in the pathogenesis of primary biliary cirrhosis. PMID: 21691115
    11. AE2 mediated-apoptosis of endothelial cells induced by high glucose was Caspase-3-dependent. PMID: 20180022
    12. AE2 operates in parallel with NHE1 to regulate pH(i) during RVD of human cervical cancer cells. PMID: 11852051
    13. Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells. PMID: 12225956
    14. findings suggest that HNF1 may have a major role in upregulating alternative transcription of the AE2 gene in the liver, and therefore it may contribute to the biliary secretion of bicarbonate in response to certain stimuli PMID: 14575719
    15. The results indicated that overexpression of AE2 may be involved in the development of human HCC. PMID: 17058451
    16. SLC4A2 colocalized with carbonic anhydrase IX in gastric mucosa. PMID: 17652430
    17. AE2 might be associated with gastric carcinogenesis and the achlorhydria experienced by gastric cancer patients. PMID: 18438347
    18. that AE2 may play an important role in the progression of hepatocellular carcinoma cells PMID: 19224338
    19. The common genetic variation of SLC4A2 does not directly affect the risk of PBC or its clinical outcome. PMID: 19491853

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Anion exchanger (TC 2.A.31) family
  • 数据库链接：

    HGNC: 11028

    OMIM: 109280

    KEGG: hsa:6522

    STRING: 9606.ENSP00000405600

    UniGene: Hs.647069