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  4. Recombinant Human Amyloid beta A4 precursor protein-binding family B member 2 (APBB2)

Recombinant Human Amyloid beta A4 precursor protein-binding family B member 2 (APBB2)

  • 中文名称：
    Recombinant Human Amyloid beta A4 precursor protein-binding family B member 2(APBB2),Yeast
  • 货号：
    CSB-YP821708HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Amyloid beta A4 precursor protein-binding family B member 2(APBB2),Yeast
  • 货号：
    CSB-EP821708HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Amyloid beta A4 precursor protein-binding family B member 2(APBB2),Yeast
  • 货号：
    CSB-EP821708HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Amyloid beta A4 precursor protein-binding family B member 2(APBB2),Yeast
  • 货号：
    CSB-BP821708HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Amyloid beta A4 precursor protein-binding family B member 2(APBB2),Yeast
  • 货号：
    CSB-MP821708HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    APBB2
  • Uniprot No.：
  • 别名：
    Amyloid beta (A4) precursor protein-binding; family B; member 2 (Fe65 like); Amyloid beta A4 precursor protein binding family B member 2; Amyloid beta A4 precursor protein-binding family B member 2; APBB 2; APBB2; APBB2_HUMAN; Fe65 like 1; Fe65 like; Fe65 like protein; FE65L 1; FE65L; FE65L1; Protein Fe65-like 1; Rirl 1; Rirl1; TR2 L; TR2L; Zfra; Zinc finger like protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-758
  • 氨基酸序列
    MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN AEIKHTETKN STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV KNGENQLRKA AEQGQQDPNK NLSPTAVINI TSEKLEGKEP HPQDSSSCEI LPSQPRRTKS FLNYYADLET SARELEQNRG NHHGTAEEKS QPVQGQASTI IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEKQP WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP HPDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL SYCKNDIRDT VGIWGEGKDM YLILENDMLS LVDPMDRSVL HSQPIVSIRV WGVGRDNGRD FAYVARDKDT RILKCHVFRC DTPAKAIATS LHEICSKIMA ERKNAKALAC SSLQERANVN LDVPLQVDFP TPKTELVQKF HVQYLGMLPV DKPVGMDILN SAIENLMTSS NKEDWLSVNM NVADATVTVI SEKNEEEVLV ECRVRFLSFM GVGKDVHTFA FIMDTGNQRF ECHVFWCEPN AGNVSEAVQA ACMLRYQKCL VARPPSQKVR PPPPPADSVT RRVTTNVKRG VLSLIDTLKQ KRPVTEMP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength. Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning. Activates transcription of APP.
  • 基因功能参考文献：
    1. APBB2 was differentially expressed between Fibromyalgia patients and healthy controls. PMID: 27157394
    2. results provide additional evidence of a genetic interaction between GSK3beta and APBB2 and further suggest that GSK3beta is involved in the pathophysiology of both of the primary neuropathologies of Alzheimer's disease PMID: 26194614
    3. The APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability. PMID: 23384821
    4. FE65L1 potentiates gamma-secretase processing of APP CTFs. This requires binding of FE65L1 to APP and APP CTFs. Enhanced APP CTF processing can be detected in early endosome vesicles PMID: 14527950
    5. rs13133980 associated significantly with age of onset in Alzheimer disease. Genetic variations in APBB2 may affect late onset AD susceptibility. PMID: 15714520
    6. the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF PMID: 16083851
    7. In response to TNF, Zfra is upregulated and modulates TNF-mediated cell death via interacting with TRADD, FADD and RIP (death-inducing signaling complex) at the receptor level, and downstream effectors NF-kappaB, p53, WOX1, and JNK1. PMID: 17567906
    8. The hCV1558625 G allele was over-represented in patients with onset under age 70 compared to controls in the same age range. PMID: 18852029
    9. The differential processing of amyloid-beta precursor via secretase enzymes regulates the proliferation and differentiation of human embryonic stem cell. PMID: 19542221

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  • 亚细胞定位：
    Endoplasmic reticulum. Golgi apparatus. Early endosome.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 582

    OMIM: 602710

    KEGG: hsa:323

    STRING: 9606.ENSP00000427211

    UniGene: Hs.479602