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  4. Recombinant Human Alpha-1A adrenergic receptor (ADRA1A), partial

Recombinant Human Alpha-1A adrenergic receptor (ADRA1A), partial

  • 货号：
    CSB-YP001385HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001385HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001385HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001385HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001385HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    ADRA1A; ADRA1C; Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
  • 基因功能参考文献：
    1. This study provided proof that SNPs within ADRA1 is significantly associated with the susceptibility to and the prognosis of cervical vertigo, so that NPY and NA might serve as the precise diagnostic marker and treatment target of cervical vertigo. PMID: 29197114
    2. Our novel data, describing the alpha1A-AR phosphorylation sites, suggest that the observed different phosphorylation patterns may participate in defining adrenoceptor localization and action, under the different conditions examined PMID: 28888989
    3. The presence of ADRA1A autoantibodies is an independent predictor for aortic stiffness progression in normotensive subjects. PMID: 29097625
    4. A mutation of rs2322333, located in the intronic and 3'UTR part of the gene ADRA1A in chromosome 8, has a probability of being deleterious the abolition of ELAV-like protein 1 (ELAVL1) binding site rs2695260. SNP rs2322333 in adrenergic receptor alpha1 (ADRA1A) was higher in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis compared with healthy controls PMID: 27835969
    5. Demonstrate the utility of alpha1 -AR agonists in the treatment of traction alopecia and hair shedding during cosmetic procedures. PMID: 26678522
    6. Immunoreactivity for ADRA1A was densely distributed in vascular smooth muscle of nasal turbinates. PMID: 26739946
    7. alpha1A-adrenoceptor subtypes predominantly contributed to human IAS contraction PMID: 25913761
    8. Data are presented that indicate that Iso represents a novel type of alpha1A-AR partial agonist with signaling bias toward MAPK/ERK signaling cascade that is likely independent of coupling to Galphaq. PMID: 25606852
    9. Data suggested ADRA1A Arg347Cys polymorphism as susceptibility factor in patients with vasovagal syncope; ArgArg genotype could be a marker for vasovagal syncope susceptibility in the Mexican population PMID: 24548768
    10. The ADRA1A mutant triggers two distinct EGFR transactivation-dependent signaling pathways: 1) constitutive Gq-independent beta-arrestin-1/Src/MMP/EGFR/ERK-dependent hyperproliferation and 2) agonist-induced Gq- and EGFR/STAT-dependent hypertrophy. PMID: 24835978
    11. The alpha-AR-induced mydriasis in mice is mediated mainly by the alphaA-AR, with a smaller contribution of the alphaB-AR, matching the relative abundance of these subtypes at the mRNA level. PMID: 25425303
    12. alpha1-AR expression is greater on nerve fibers in skin affected by complex regional pain syndrome type II (CRPS) than in unaffected skin from the same patient or from pain-free controls. PMID: 24342464
    13. Adrenergic alpha1A receptor subtypes transactivate epidermal growth factor receptors. PMID: 23902938
    14. alpha1A-AR, when located in the plasma membrane, signal through calcium and ERK1/2 pathways but, when it translocates to deeper endosomes, continues signaling through ERK1/2 and could also activate the p38 pathway. PMID: 23717684
    15. Upon receptor activation, prostate alpha1A-adrenoceptors bind clathrin LCA. PMID: 23460120
    16. Presence of the Arg347 allele in the ADRA1A gene is a risk factor for occurrence of more severe metabolic abnormalities in patients with schizophrenia. PMID: 22037178
    17. Arg492Cys polymorphism in the alpha(1A) -AR gene was associated with heart rate reactivity to stress in young African Americans. PMID: 22091949
    18. [review] Altered adrenergic receptor signaling following brain trauma contributes to memory dysfunction. PMID: 21792097
    19. Data show that elevated levels of matrix metalloproteinase-7 (MMP7) and a disintegrin and metalloproteinase-12 (ADAM12) in alpha(1a)-247R-expressing cells are responsible for EGF receptor (EGFR) transactivation. PMID: 22089237
    20. Alpha1-adrenoceptor signaling in the human prostate involves regulation of p38 mitogen-activated protein kinase PMID: 21982020
    21. Data suggest that the endocytic pathway is involved in alpha(1A)-AR-induced ERK1/2 activation, which is independent of G(q)/PLC/PKC signaling. PMID: 21738688
    22. Study of alpha1-AR subtype expression on both human monocytes and macrophages illustrates a mechanism by which increased interleukin (IL)-1beta production can be modulated by alpha1-AR input. PMID: 21571945
    23. The mRNA expression of alpha1a-AR subtypes in bladder detrusor and posterior urethra was significantly higher in the inflammation group than in controls. PMID: 21223784
    24. the rs17055869 SNP near the 3' end of ADRA1A is significantly associated with metabolic syndrome and it may be involved in determining a greater level of sympathetic activation in metabolic syndrome patients PMID: 21519279
    25. interactions between metal ions and the alpha(1A)-adrenoceptor with affinities compatible with physiological concentrations PMID: 21262225
    26. Genetic variations in alpha-1A and beta-2 adrenergic receptors (ADRA1A, ADRB2) have been associated with changes in smooth muscle tone in various tissues, and implicated in bronchial hyper-responsiveness, metabolic syndrome, and other disorders. PMID: 19730237
    27. No association of the polmorphisms Arg492Cys (ADRA1A gene), Ser49Gly and Arg389Gly (ADRB1), Arg16Gly and Gln27Glu (ADRB2), 825C/T (GNB3), -1021C/T (DBH) and S/L (SLC6A4) with both tilt test outcomes and new syncopal episodes was found PMID: 20129829
    28. This study suggests the rs1048101 single nucleotide polymorphism within the alpha1a-adrenoceptor as one risk factor for the development of CRPS I after the distal radius fracture. PMID: 20173430
    29. Report a new alpha(1A)AR-CMC-online-HPLC/MS method can be applied for screening active components acting on alpha(1A)AR from traditional Chinese medicines exemplified by Radix Caulophylli. PMID: 20004544
    30. Our study suggests that the ADRA1A gene is involved in weight gain among schizophrenia patients treated with antipsychotics. PMID: 19918262
    31. alpha(1A)-adrenoceptor stimulation in androgen-independent prostate cancer cells via caveolae constitutes one of the mechanisms contributing to their protection from thapsigargin-induced apoptosis PMID: 19763272
    32. the inheritance of polymorphisms in the ADRA2A and ADRA1C genes in 113 nuclear families provided no significant evidence for linkage for these two genes; these genes are not major genetic factors contributing to the susceptibility to GTS PMID: 12707939
    33. alpha1-ARs play a role in promoting human prostate cancer epithelial cell proliferation via transient receptor potential channels PMID: 12782672
    34. Candidate gene for benign prostatic hyperplasia. PMID: 15136785
    35. alpha1A-adrenoceptor structural computer model PMID: 15474515
    36. alpha(1a)-ARs recycle rapidly by an agonist-independent, constitutive, beta-arrestin-dependent process and that this can transport "alpha-blockers" into cells carrying these receptors. PMID: 15626751
    37. The N terminus of RGS2 was required for association with alpha1A-ARs and inhibition of signaling, and amino acids Lys219, Ser220, and Arg238 within the alpha1A-AR i3 loop were found to be essential for this interaction PMID: 15917235
    38. Genetic variations in the ADRA1A gene are significantly associated with essential hypertension in this Chinese population. PMID: 16685204
    39. mTLD interacts with alpha(1A)-AR directly, alters the subcellular localization of receptor, and influences agonist-induced alpha(1A)-AR internalization and calcium signaling. PMID: 16690783
    40. The presence of alpha(1A)-adrenoceptors in epididymal smooth muscle and epithelial cells indicates their contribution to smooth muscle contractile responses and a possible role in the activities of the epithelium lining the epididymal duct. PMID: 18351393
    41. These findings suggest that stimulation of cutaneous alpha(1)-adrenoceptors increased the excitability of heat-sensitized nociceptive afferents. PMID: 18524654
    42. These data provide evidence for a potential clinical relevance for alpha(1)-AAB in hypertensive patients, and the notion of immunity as a possible cause of hypertension. PMID: 19011682
    43. Arg347Cys polymorphism is associated with blood pressure phenotypes, in a large sample of Brazilians from an urban population PMID: 19105822
    44. Administration of an alpha-1A-specific blocker reduced analgesic dosage and colic episodes after shock wave lithotripsy of lower ureteral stones. PMID: 19322003
    45. strongest signal emerged from SNPs in the promoter region (rs3808585) and in an intron (rs17426222, rs4732682, rs573514) of ADRA1A, all located within the same haplotype block PMID: 19352218
    46. Arg347Cys polymorphism of alpha1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS. PMID: 19444285
    47. The localization of alpha1AAR in lipid rafts directly impacts both basal and activated receptor signaling. PMID: 19520158
    48. Adrenergic receptor (alpha(1A)-AR, beta(2)-AR, and beta(3)-AR) gene polymorphisms are related to the risk of developing fibromyalgia (FM) and are also linked to different domains of the FM syndrome. PMID: 19565482

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  • 亚细胞定位：
    Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA1A sub-subfamily
  • 组织特异性：
    Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with hi
  • 数据库链接：

    HGNC: 277

    OMIM: 104221

    KEGG: hsa:148

    STRING: 9606.ENSP00000369960

    UniGene: Hs.52931