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  4. Recombinant Human Alpha-1-antichymotrypsin (SERPINA3)

Recombinant Human Alpha-1-antichymotrypsin (SERPINA3)

  • 货号：
    CSB-YP021059HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021059HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021059HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021059HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021059HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SERPINA3
  • Uniprot No.：
  • 别名：
    SERPINA3; AACT; AACT_HUMAN; ACT; alpha 1 Antichymotrypsin; Alpha-1-antichymotrypsin His-Pro-less; Antichymotrypsin; Cell growth inhibiting gene 24/25 protein ; Cell growth-inhibiting gene 24/25 protein; GIG24; GIG25; Growth inhibiting protein 24; Growth inhibiting protein 25; MGC88254; Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase; antitrypsin) member 3; Serine (or cysteine) proteinase inhibitor clade A member 3; Serine proteinase inhibitor clade A member 3; Serpin A3; Serpin family A member 3; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3; SERPINA3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-423
  • 氨基酸序列
    HPNSPLD EENLTQENQD RGTHVDLGLA SANVDFAFSL YKQLVLKAPD KNVIFSPLSI STALAFLSLG AHNTTLTEIL KGLKFNLTET SEAEIHQSFQ HLLRTLNQSS DELQLSMGNA MFVKEQLSLL DRFTEDAKRL YGSEAFATDF QDSAAAKKLI NDYVKNGTRG KITDLIKDLD SQTMMVLVNY IFFKAKWEMP FDPQDTHQSR FYLSKKKWVM VPMMSLHHLT IPYFRDEELS CTVVELKYTG NASALFILPD QDKMEEVEAM LLPETLKRWR DSLEFREIGE LYLPKFSISR DYNLNDILLQ LGIEEAFTSK ADLSGITGAR NLAVSQVVHK AVLDVFEEGT EASAATAVKI TLLSALVETR TIVRFNRPFL MIIVPTDTQN IFFMSKVTNP KQA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
  • 基因功能参考文献：
    1. SERPINA3 silencing inhibits the migration, invasion, and liver metastasis of colon cancer cells. PMID: 29855767
    2. evaluation of serum proteins reveals that SERPINA1, SERPINA3 and SERPINC1 could be useful to discriminate healthy from colorectal carcinoma patients with a high sensitivity and specificity PMID: 27492143
    3. This study confirms the prognostic potential of SERPINA3 expression in human cutaneous melanoma PMID: 27213583
    4. AACT is downregulated in NSCLC. The GlcNAcylated AACT can effectively differentiate Stage I non-small cell lung cancer from healthy or benign lung disease samples. PMID: 26908325
    5. The ACT gene (also named SERPINA3) was mapped on chromosome 14q32.1 We studied the association between Alpha-1 antichymotrypsin (ACT) signal peptide A/T polymorphism polymorphism and risk of primary intracerebral hemorrhage PMID: 26210716
    6. Proteome demonstration of alpha-1-acid glycoprotein and alpha-1-antichymotrypsin candidate biomarkers for diagnosis of enterovirus 71 infection PMID: 25170552
    7. SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis. PMID: 24817931
    8. ACT-17 variation presents a risk factor for Alzheimer's disease in the worldwide population, especially in the Caucasian population. PMID: 22272609
    9. This study demonistrated that SERPINA3 is changed in the dorsolateral prefrontal cortex of individuals with schizophrenia PMID: 22869038
    10. Prostate specific antigen (PSA) forms complexes with alpha1-antichymotrypsin (ACT) within the prostate, which may explain, at least partially, why the ratio of serum PSA-ACT to total PSA is increased in prostate cancer. PMID: 22806587
    11. the promoter of SERPINA3 is transcriptionally activated by three transcription factors (SP1, MZF1 and ZBTB7B) PMID: 22246292
    12. The common alpha1-antichymotrypsin signal peptide -15A/T polymorphism may not be a major risk factor for Alzheimer disease (AD) but the polymorphism is capable of increasing late onset AD risk. [Meta-analysis] PMID: 22294107
    13. Pivotal role for alpha1-antichymotrypsin in skin repair PMID: 21693707
    14. alpha-1 antichymotrypsin C-terminal fragment and Apo A1 provide a plasma molecular profile, and this is associated with acute cellular renal allograft rejection. PMID: 21730889
    15. human plasma serine protease inhibitor alpha(1)-antichymotrypsin inhibits staphopain C PMID: 21296644
    16. The Alpha 1 antichymotrypsin is an independent histological prognostic marker for patients with Melanoma, especially those with Stage III melanoma. PMID: 20444200
    17. Found a marked and persistent coronary artery bypass grafting (CABG) postoperative increase in the levels of the serpin-protease inhibitor alpha(1)-antichymotrypsin that fully maintains the inhibitory activity blunting its protease substrate cathepsin G. PMID: 20302328
    18. The study concluded that the effect of the variations in the alpha-1-antichymotrypsin regulatory region must be very limited. PMID: 20378355
    19. The ANTICHYMOTRYPSIN genotype and allele frequency are not different in Indian cerebral hemorrhage and cerebral ischemia compared to controls. PMID: 19959196
    20. No cirrhosis secondary to ACT deficiency has been reported in children. PMID: 20158662
    21. AAT efficiently inhibits both heat- and chemical-induced aggregation of various test proteins. PMID: 20117085
    22. The rs4934 polymorphism of SERPINA3 is not associated with sporadic intracranial aneurysms among individuals of Chinese Han ethnicity. PMID: 19907165
    23. alpha(1)-antichymotrypsin polymorphism: a risk factor for hemorrhagic stroke in normotensive subjects. PMID: 11692021
    24. A25G and G39A substitutions in the AACT gene are probably one of the risk factors to Alzheimer's disease (AD) in Han Chinese. PMID: 11798857
    25. no association seen between alpha 1-antichymotrypsin and time to psychosis in Alzheimer's disease PMID: 11936240
    26. significantly higher in plasma of Alzheimer patients compared to controls PMID: 11959399
    27. data suggested that the ApoE epsilon2/epsilon4 genotype might be a susceptibility variant of moderate effect for sporadic idiopathic Parkinson disease in our samples, whereas the ACT gene signal peptide polymorphism might not PMID: 11992569
    28. Gene regulation of the serine proteinase inhibitors alpha1-antitrypsin and alpha1-antichymotrypsin. PMID: 12023832
    29. alpha(1)-antitrypsin and antichymotrypsin are produced by the mammary gland and are present in milk in relatively high amounts in early lactation PMID: 12324297
    30. Polymeric AACT specifically seeds the polymerization of native protein by a serpin-dependent process that occurs under physiological conditions and may be important in the deposition of AACT in plaques in patients with Alzheimer's disease. PMID: 12600202
    31. overexpression of ACT by astrocytes could thus contribute to increased beta-amyloid fibril formation in Alzheimer's disease PMID: 15530656
    32. Alpha1-antichymotrypsin-AA may confer a modest protection against developing early-onset Parkinson disease in women PMID: 15542006
    33. Multivariate analysis showed that ACT mRNA level, but not STC2 mRNA level, in HR-positive patients, was a significant prognostic factor (P = 0.042), which was independent of tumor size and lymph node metastases. PMID: 15546506
    34. The ACT TT promoter genotype was associated with an increased risk of EOAD independently from the presence of the apolipoprotein E (APOE) epsilon 4 allele. PMID: 15653173
    35. serpin/furin complex stability depends on pH and regulation at the deacylation step PMID: 15659365
    36. the A/T polymorphism of SERPINA3 gene is associated with the risk factor for aneurysmal subarachnoid hemorrhage PMID: 15718509
    37. The onset of MSA was significantly earlier and the disease progressed significantly faster in patients with ACT-AA genotype than in those with non-ACT-AA genotypes. The ACT concentration in cerebrospinal fluid was increased in patients with ACT-AA. PMID: 15907346
    38. This study findings suggest that ACT polymorphism (A/T) is a risk factor for post-stroke dementia. PMID: 15935385
    39. AP-1 is a key transcription factor that, in part, controls astrocyte-specific expression of genes including the ACT and GFAP genes PMID: 16303762
    40. SERPINA3 polymorphism does not have a role in primary intracerebral hemorrhage in a Polish population PMID: 16424370
    41. NFI-X cooperates with (activator protein 1)AP-1 by an unknown mechanism in astrocytes, which results in the expression of a subset of astrocyte-specific genes. PMID: 16565071
    42. acute myocardial infarction from information on functional gene variants that favor inflammation or modulate cholesterol metabolism: IL6 -174 G/C, TNF -308 G/A, IL10 -1082 G/A, SERPINA3 -51 G/T, IFNG +874 T/A, HMGCR -911 C/A, and APOE epsilon2/3/4 PMID: 18056971
    43. We conclude that APOE is a risk gene for amnestic mild cognitive impairment and that ACT and CHRNA7 may act in these patients as modifier genes for the time of progression to Alzheimer's disease. PMID: 18078695
    44. Nur77 overexpression and RNA interference-mediated Nur77 gene knockdown analysis confirmed that SerpinA3 is indeed a novel Nur77-targeted gene. PMID: 18248459
    45. A correlation of PSA levels and the alpha 1 antichymotrypsin genotype in young prostate carcinoma patients was found. PMID: 18383875
    46. Alpha-1-antichymotrypsin is a pathophysiologic inhibitor that controls MMP-9 activation in skin tissue. PMID: 18401426
    47. Our study did not show an association between alpha-1 antichymotrypsin signal peptide A/T polymorphism and primary intracerebral hemorrhage. PMID: 18408372
    48. increased peripheral ACT levels in APOE 4 positive patients appear to predict an accelerated clinical progression PMID: 18991685
    49. Ox-ACT promotes release of human monocyte chemoattractant protein-1 (MCP-1) and IL-8 from human lung type epithelial cells (A549) and normal human bronchial epithelial (NHBE) cells PMID: 19525388
    50. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Serpin family
  • 组织特异性：
    Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
  • 数据库链接：

    HGNC: 16

    OMIM: 107280

    KEGG: hsa:12

    STRING: 9606.ENSP00000376793

    UniGene: Hs.534293