Recombinant Human Age-related maculopathy susceptibility protein 2 (ARMS2)

1. antioxidant and zinc nutritional supplement modifies risk of macular degeneration progression according to rs10490924 or 372_815del443ins54 genotype PMID: 29311295
2. Our analysis showed stronger contribution of ARMS2 in age-related macular degeneration (AMD) with reticular pseudodrusen (RPD) group versus AMD without RPD group, in comparison with CFH genotypes. PMID: 28593728
3. ARMS2 variants are likely associated with the 3-year outcomes of photodynamic therapy in patients with wet age-related macular degeneration. PMID: 28761324
4. because the ARMS2/HTRA1 genes are positioned at a locus on chromosome 10q26 in a region with strong linkage disequilibrium, it is difficult to distinguish the functions of the individual genes. a review of recent epidemiological studies of Age-related macular degeneration(AMD) is offered. An argument for a definite correlation between the ARMS2 gene and AMD is presented PMID: 28583181
5. In polypoidal choroidal vasculopathy patients, ARMS2 rs10490924 showed association with anatomic therapeutic response to anti-VEGF, suggesting pharmacogenetic relationship. PMID: 29212537
6. The ARMS2 A69S polymorphism was associated with CNV recurrence rate in our patient cohort. Prediction of a greater risk of recurrence could help to design more appropriate follow-up treatment strategies for patients with neovascular AMD. PMID: 28744656
7. Complement factor H Y402H (rs1061170) and age-related maculopathy susceptibility2 (ARMS2)/LOC387715 A69S (rs10490924) polymorphisms shown to have significant association with age-related macular degeneration (Meta-Analysis). PMID: 27269047
8. The present meta-analysis revealed that the ARMS2 A69S risk variants confer a significantly greater risk of retinal angiomatous proliferation compared with neovascular age-related macular degeneration. PMID: 28005184
9. we speculate that up-regulation of leptin and ARMS2 forms part of an important survival mechanism to compensate for placental growth discordance in monochorionic diamniotic twin pregnancies PMID: 28303777
10. This analysis revealed the synergistic effect of these two factors indicating that there is a common pathway of ARMS2/LOC387715 and smoking in AMD pathogenesis which may be the complement system pathway. PMID: 28095100
11. The findings of the present study provide evidence that CFH gene variants and ARMS2/HTRA1 genes play a major role in the genetic susceptibility to AMD in a Greek population. These findings are of direct relevance for disease and help mapping the genetic chart of AMD. PMID: 26848857
12. Development of polypoidal choroidal vasculopathy (PCV) in the unaffected fellow eye is associated with ARMS2 A69S genotype in patients with unilateral PCV. PMID: 26332911
13. OCT scans revealed lower retinal thickness in patients homozygous for CFH or ARMS2, which was caused by a significantly reduced photoreceptor layer. The number and ultrastructure of drusen were also significantly different. PMID: 28558370
14. This study suggests that in familial age-related macular degeneration patients, the common genetic risk variant in ARMS2 is less important compared to sporadic age-related macular degeneration. PMID: 27258093
15. this work we show that ARMS2 is externalized via an unconventional pathway bypassing Golgi. PMID: 27270414
16. Interaction effects between supplement groups and individual complement factor H (CFH) Y402H and age-related maculopathy susceptibility 2 (ARMS2) genotypes, and composite genetic risk groups combining the number of risk alleles for both loci, were evaluated for their association with progression PMID: 27471039
17. EMD were not AMD-independently associated with CFH or ARMS2 genotypes. Our results indicate that patients without AMD but with EMD can serve as controls in studies evaluating AMD risk factors. PMID: 26614632
18. Variants in ARMS2 carry risk of age-related macular degeneration. PMID: 27879347
19. CFH, ARMS2, and C3 were associated with specific features of neovascularization at the time patients were enrolled in Comparison of Age-Related Macular Degeneration Treatments Trials . PMID: 27099955
20. Subfoveal choroidal thickness and choroidal vascular hyperpermeability in eyes with treatment-naive polypoidal choroidal vasculopathy were associated with ARMS2 A69S (rs10490924) and CFH (rs1329428). PMID: 26745149
21. Studies indicate that the high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2, and HTRA1 with high linkage disequilibrium. PMID: 26427389
22. No significant interaction was found between DHA supplementation benefit and ARMS2 A69S SNP. PMID: 26132079
23. These results suggest that there is a contribution of the rs10490924 SNP of the LOC387715/ARMS2 gene to AMD susceptibility in this sample of the Brazilian population. PMID: 24372405
24. Determined the differential effects of genetic polymorphism in CFH and ARMS2 on risk of age-related macular degeneration (AMD) PMID: 25786237
25. The growth of choroidal neovascularization in AMD would be affected by 2 genes: MMP20, a newly confirmed gene expressed in the retina, and ARMS2/HTRA1, a well-known susceptibility gene for AMD. PMID: 26337002
26. results suggest that calcium, ARMS2 genotype, C. pneumonia infection, and age are significant factors in the development of the early stages of AMD. PMID: 25792034
27. In this study, we found that the interaction of ARMS2 and ARMS2/HTRA1 is significantly associated with nAMD, and the interaction of CFH and ARMS2 is pronounced in PCV development in Chinese population. PMID: 25771815
28. GRS using ARMS2, CFH, TNFRSF10A, VEGFA, and CFI was significantly associated with second-eye involvement. Genetic risk has high predictive ability for second-eye involvement of AMD. PMID: 26275133
29. Patients carrying 4 risk alleles in CFH and ARMS2 developed neovascular AMD 12.2 (95% CI, 6.2-18.3) years earlier than patients with zero risk alleles (P < .001). PMID: 25695752
30. Gene variants in CFH, ARMS2 and HTRA1 are related to an increased risk of age-related macular degeneration in a northern Chinese population. PMID: 24865190
31. This study shows an association between A69S polymorphism in the ARMS2 gene and the anti-angiogenesis treatment response. PMID: 25185256
32. High-risk alleles in the CFH and ARMS2/HTRA1 genes were not associated with increasing autosomal dominant radial drusen severity. PMID: 25077532
33. Chronic chronic central serous chorioretinopathy (CSC) is associated with genetic variants in ARMS2 and CFH, indicating a genetic and pathophysiologic overlap between cCSC and age-related macular degeneration. PMID: 25439433
34. The association with the CFH Y402 risk allele was less pronounced in retinal angiomatous proliferation patients (RAP) than in non-RAP CNV patients, while the association with high age and arterial hypertension appeared to be stronger. PMID: 24847905
35. HTRA1 gene is transcriptionally regulated by insertion/deletion nucleotides located at the 3' end of the ARMS2 gene in patients with age-related macular degeneration. PMID: 25519903
36. Genotypes at the CFH and ARMS2 loci did not statistically significantly alter the benefits of Age-Related Eye Disease Study (AREDS) supplements. PMID: 24974817
37. There is association of ARMS2 gene polymorphism with different subtypes of Age-related macular degeneration PMID: 25715554
38. The benefit of the AREDS formulation seems the result of a favorable response by patients in only 1 genotype group, balanced by neutral or unfavorable responses in 3 genotype groups. PMID: 25200399
39. The combined geographic atrophy/choroidal neovascularization phenotype has similar epidemiologic, clinical, and genetic features. PMID: 25091949
40. study revealed significant relationships between the plasma malondialdehyde level and ARMS2 variants and phenotypes in polypoidal choroidal vasculopathy and neovascular age-related macular degeneration PMID: 24240564
41. Eyes with exudative macular degeneration, reticular pseudodrusen is more common in eyes with retinal angiomatous proliferation having a thin choroid at the fovea, especially in old, female patients with the risk variant of ARMS2 A69S. PMID: 24595987
42. Variants in CFH, ABCA1, and ARMS2 genes are related to the presence and progression of drusen in early age-related macular degeneration. PMID: 24970616
43. Index variants of AMD, rs1061170 (CFH) and rs10490924 (ARMS2), were associated with AMD at P=3.05x10(-8) and P=6.36x10(-6), respectively, in European Americans. PMID: 25205864
44. A total of 12 weeks of exposure to mainstream cigarette smoke led to CNV rates of 7.7% for wild type (Wt) mice and 20% for HtrA1 Tg mice, but had no effect on ARMS2 Tg mice. PMID: 25205867
45. Exudative age-related macular degeneration is associated with CFH Y402H and ARMS2 A69S polymorphisms, smoking and with nutritional factors; a decreased risk with dietary omega-3 fatty acids and fruits. PMID: 24362810
46. There were no statistically significant interactions between current smoking or pack-years smoked and CFH or ARMS2 genotype in age-related macular degeneration. PMID: 24953792
47. Our results show that genotypes of ARMS2 (rs10490923), HTRA1 (rs112000638) and CFH (rs1410996) polymorphisms are related to an increased risk of suffering AMD in Spanish patients. PMID: 23534868
48. ARMS2 and C3 are major contributors to advanced age-related macular degeneration in Mexican patients, while the contributions of CFH, C2, and CFB are minor to those of other populations. PMID: 24453474
49. This study did not show a correlation between ARMS2, C3, MT-NDH2, and CFH alleles in the development of choroid neovascularization associated with ocular histoplasmosis. PMID: 24612979
50. These data suggest that polymorphisms of the ARMS2 do not modify the progression of the central field of vision in RP patients. PMID: 24217333

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HGNC: 32685

OMIM: 611313

KEGG: hsa:387715

STRING: 9606.ENSP00000436682

UniGene: Hs.120359