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  4. Recombinant Human ADP-ribosyl cyclase 2 (BST1)

Recombinant Human ADP-ribosyl cyclase 2 (BST1)

  • 货号：
    CSB-YP611986HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP611986HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP611986HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP611986HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP611986HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BST1
  • Uniprot No.：
  • 别名：
    ADP ribosyl cyclase 2; ADP-ribosyl cyclase 2; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Bone marrow stromal antigen 1; Bone marrow stromal cell antigen 1; BST 1; BST-1; BST1; BST1_HUMAN; cADPr hydrolase 2; CD157; CD157 antigen; Cyclic ADP ribose hydrolase 2; Cyclic ADP-ribose hydrolase 2; NAD(+) nucleosidase; OTTHUMP00000217617
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    29-293
  • 氨基酸序列
    GA RARWRGEGTS AHLRDIFLGR CAEYRALLSP EQRNKNCTAI WEAFKVALDK DPCSVLPSDY DLFINLSRHS IPRDKSLFWE NSHLLVNSFA DNTRRFMPLS DVLYGRVADF LSWCRQKNDS GLDYQSCPTS EDCENNPVDS FWKRASIQYS KDSSGVIHVM LNGSEPTGAY PIKGFFADYE IPNLQKEKIT RIEIWVMHEI GGPNVESCGE GSMKVLEKRL KDMGFQYSCI NDYRPVKLLQ CVDHSTHPDC ALKSAAAATQ RKA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
  • 基因功能参考文献：
    1. SNPs rs28532698 and rs4301112 in CD157 are not significantly associated with childhood autism spectrum disorder or the severity of the disease in a Chinese Han population. PMID: 29216786
    2. the rs4698412 variant of BST-1 may increase the Parkinson disease susceptibility. [META-ANALYSIS] PMID: 25986899
    3. Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells. PMID: 24413464
    4. A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157. PMID: 25250980
    5. Studies indicate that vertebrate ADP-ribosyl cyclases (ARCs) Bst1 and CD38 with common gene structure of invertebrate ARC, suggesting the origin to the ancestor of bilaterian animals. PMID: 24896331
    6. Autism and with features of regression-previously acquired speech lost in the second year of life. The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript. PMID: 24634087
    7. BST1 rs11724635 polymorphism can interact with well water drinking to increase the risk of Parkinson's disease in a Taiwanese population. PMID: 24342025
    8. These findings indicate a central role of CD157 in cell-extracellular matrix interactions and make CD157 an attractive therapeutic target in inflammation and cancer. PMID: 24753259
    9. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in Parkinson's disease. PMID: 24795584
    10. A ligand-receptor complex SCRG1/BST1 axis facilitate mesenchymal stem cells migration, preserve OCT4 and CD271 expression, self-renewal and osteogenic differentiation. PMID: 24413464
    11. The results of this study indicated that the SNCA and BST1 SNPs generally increase the risk of developing PD and that SNCA rs11931074 in particular is associated with a higher risk of parkinson disease with family history. PMID: 23853107
    12. The results of this study showed that no causative mutation in the BST1 gene in patients with Parkinson's disease. PMID: 23827523
    13. This study confirmed the associations of BST1 with parkinson disease susceptibility and fail to show significant associations of alzheimer disease genome-wide association study (GWAS) top hits with PD susceptibility in a Korean population. PMID: 23820587
    14. BST1 SNPs rs11931532, rs12645693, & rs11724635 did not correlate with sporadic PD. The relationship of rs11724635 & sporadic PD had borderline significance. Smoking or caffeine intake did not correlate with SNP rs11724635 affecting sporadic PD. PMID: 23026536
    15. Findings implicate CD157 in the progression of EOC to metastatic disease and suggest that CD157 may represent a valuable therapeutic target. PMID: 22916288
    16. The SNPs investigated in the BST1, PARK15 and PARK9 genes associated with PD susceptibility are not associated with PD in the northern Han Chinese population. PMID: 22490479
    17. Direct replication of single nucleotide polymorphisms (SNPs) within SNCA and BST1 confirmed these two genes to be associated with the Parkinson's Disease in the Netherlands. PMID: 21248740
    18. The CD157-integrin partnership provides optimal adhesion and transmigration of human monocytes. PMID: 21478153
    19. found converging evidence of association with Parkinson's disease on 12q24 (rs4964469, combined P = 2.4 x 10(-7)) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 x 10(-6)), previously reported in Japanese data PMID: 21084426
    20. PARK16, PARK8, and PARK1 loci but not BST1 are found to be associated with Parkinson's disease. PMID: 20697102
    21. CD157 plays a pivotal role in the control of ovarian cancer cell migration and peritoneal invasion, and it may be clinically useful as a prognostic tool and therapeutic target. PMID: 20639476
    22. crystal structures of the extracellular region of human BST-1 at atomic resolution in the free form and in complexes with five substrate analogues: nicotinamide, NMN, ATPgammaS, ethenoNADP, and ethenoNAD PMID: 11866528
    23. CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties [review] PMID: 12415565
    24. Deficient in paroxysmal nocturnal hemoglobinemia; crucial to regulation of innate immunity during inflammation. PMID: 15328157
    25. The results confirm that CD157 physically interacts with CD11b/CD18 complex in human neutrophils PMID: 18211745
    26. Results show that CD38 and CD157 are expressed constitutively by corneal cells: CD38 appears as a 45-kDa monomer, while CD157 is a 42- to 45-kDa doublet. PMID: 19052657

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    ADP-ribosyl cyclase family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 1118

    OMIM: 600387

    KEGG: hsa:683

    STRING: 9606.ENSP00000265016

    UniGene: Hs.720344