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  4. Recombinant Human 40S ribosomal protein S19 (RPS19)

Recombinant Human 40S ribosomal protein S19 (RPS19)

  • 货号：
    CSB-YP020388HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP020388HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP020388HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP020388HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP020388HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RPS19
  • Uniprot No.：
  • 别名：
    40S ribosomal protein S19; DBA; DBA1; HGNC:10402; Ribosomal protein S19; rps19; RS19_HUMAN; S19
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-145
  • 氨基酸序列
    PGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE NWFYTRAAST ARHLYLRGGA GVGSMTKIYG GRQRNGVMPS HFSRGSKSVA RRVLQALEGL KMVEKDQDGG RKLTPQGQRD LDRIAGQVAA ANKKH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for pre-rRNA processing and maturation of 40S ribosomal subunits.
  • 基因功能参考文献：
    1. Study shows that the depletion of RPS19 causes a reduction of 47S rRNA synthesis in a number of cell lines of different origins. PMID: 27734913
    2. The results show that RPS19, RPS21 or RPS24 are upregulated in malignant tissue and may serve as putative biomarkers for prostate cancer. PMID: 29016636
    3. Study of genetic risk of prevalent hrHPV infections in Nigerian women found significant associations with SNPs on ribosomal protein gene S19 (RPS19) and Thymidylate Synthase gene (TYMS), in an allelic model. This risk remained significant, after adjusting for age, body mass index, smoking, age at menarche, age at sexual debut, lifetime total number of sexual partners and the total number of pregnancies. PMID: 23826176
    4. Reducing RPS19 in tumor cells or blocking the C5a receptor 1-RPS19 interaction decreases RPS19-mediated immunosuppression, impairs tumor growth, and delays the development of tumors in a transgenic model of breast cancer PMID: 28228558
    5. RPS19-downregulated erythroleukemia cells show reduced FLVCR1a and FLVCR1b mRNA levels associated with heme overload. PMID: 26058344
    6. Loss of RPS19 expression is associated with Diamond-Blackfan anemia. PMID: 25216681
    7. Mutations R62W and R101H impair RPS19 ability to associate with the ribosome. PMID: 25069755
    8. Data indicate that GATA1 transcription factor is downregulated in ribosomal protein S19 (RPS19)-deficient cells through upregulation of TNF-alpha and p38 MAPK. PMID: 25270909
    9. RPS19 mutation is associated with Diamond Blackfan Anemia. PMID: 25132370
    10. A binding domain for RPS19 was identified and characterized in the N-terminus. PMID: 25062117
    11. increase of autophagy in cells derived from DBA patients, in CD34+ erythrocyte progenitor cells with RPS19 knock down, in the red blood cells of zebrafish embryos with RP-deficiency, and in cells from patients with Shwachman-Diamond syndrome PMID: 24875531
    12. High frequency of RPS19 gene deletion is associated with Italian Diamond-Blackfan anemia. PMID: 22689679
    13. RPS19 mutations induced a decrease in proliferation of progenitor cells, but the terminal erythroid differentiation was normal with little or no apoptosis. PMID: 22833095
    14. Single nucleotide polymorphisms in the RPS19 and RPS19 is associated with HPV persistence and cervical precancer/cancer. PMID: 22496757
    15. the monocyte C5aR selectively activates the classical pathway with the binding of C5a and the alternative pathway with the binding of C5a/RP S19. PMID: 21613290
    16. The RPS19 gene uses a broad range of transcriptional start sites and a short 5'UTR is associated with increased levels of RPS19. PMID: 21412415
    17. translocation of RP S19 from prothrombin to platelets during blood coagulation PMID: 21306436
    18. N-mediated translation initiation mechanism, which lures the host translation machinery for the preferential translation of viral transcripts, primarily depends on the N-RPS19 interaction. PMID: 21296889
    19. PIM1 may act as a sensor for ribosomal stress independently of or in concert with the known p53-dependent mechanisms. PMID: 20639905
    20. approximately 30% of RPS19 mutations are missense mutations that do not alter the stability of the RPS19 protein and are hypothesized to act by a dominant negative mechanism in Diamond-Blackfan anemia PMID: 20606162
    21. Data show that when a Gi/PI3K pathway is partially blocked, C5a receptors stimulate an alternative p38MAPK pathway. PMID: 20473571
    22. RPS19 binds specifically to the 5' untranslated region of its own mRNA; Diamond-Blackfan anemia missense mutations introduced into RPS19 impair this binding. PMID: 20395159
    23. A molecule indistinguishable from RP S19 was present in plasma, and that the RP S19-like molecule was converted to the active form by a transglutaminase-catalyzed reaction. PMID: 20093496
    24. Genetic variants in the noncoding region of RPS19 gene in Diamond-Blackfan anemia: potential implications for phenotypic heterogeneity. PMID: 20054847
    25. Study suggests that RPS19 overexpression might be a universal signal in rapid cell growth tissues. PMID: 11942409
    26. results indicated that the conversion of the RP S19 dimer from agonist to antagonist of C5a receptor is attributed to the IAGQVAAANKK moiety between Ile134 and Lys144 PMID: 12651630
    27. Histopathological grading of the HNSCC biopsies correlated significantly with the S19 mRNA expression levels. PMID: 15330156
    28. RPS19 silencing decreases the proliferative capacity of hematopoietic progenitors and leads to a defect in erythroid development PMID: 15626736
    29. Deficiency of RPS19 blocks proliferation of immature erythroid progenitor cells; dexamethasone activates proliferation of the same cell population through mechanisms independent of RPS19 PMID: 15755903
    30. Rps19 has a role in the assembly and maturation of the pre-40 S ribosomal particles PMID: 16159874
    31. The PIM-1/RPS19 interaction was demonstrated both in vitro and in living cells and led to phosphorylation of RPS19 in an in vitro kinase assay. PMID: 16266891
    32. in CD34- cells from the bone marrow of patients with DBA harboring mutations in RPS19 was revealed a pre-rRNA-processing defect similar to that observed in TF-1 cells where RPS19 expression was reduced PMID: 16990592
    33. ribosome biogenesis and nucleolar organization is altered in skin fibroblasts from DBA patients bearing mutations in the RPS19 gene PMID: 17053056
    34. RPS19 mutations affecting RPS19 conserved arginines R56Q and R62Q could significantly inhibit the rate of protein synthesis, indicating the importance of RPS19 in translation. PMID: 17082006
    35. RPS19 is a ribosomal protein linked to Diamond-Blackfan anemia PMID: 17178250
    36. The RP S19 dimer inhibits C5a-induced neutrophil migration and promotes apoptosis of neutrophils via the C5a receptor. PMID: 17199736
    37. Diamond-Blackfan anemia missense mutations affect the assembly of ribosomal protein S19 into the ribosome PMID: 17517689
    38. RPS19 deficiency causes apoptosis and accelerated loss of erythroid progenitors in RPS19-deficient Diamond-Blackfan anemia. PMID: 17962699
    39. patients with RPS19 mutations display a poorer response to steroids and a worse long-term prognosis compared to other Diamond-Blackfan anemia patients (Review) PMID: 18412286
    40. Demonstration of an important role for the proteasomal degradation pathway in regulating the expression levels and nucleolar localization of certain mutant RPS19 proteins in Diamond-Blackfan anemia. PMID: 18768533
    41. RPS19 significantly compromised CXCR2-dependent MIF-triggered adhesion of monocytes to endothelial cells under flow conditions. We, therefore, propose that RPS19 acts as an extracellular negative regulator of MIF. PMID: 19155217
    42. siRNA knock-down of RPS19 results in a relative decrease of small subunit r-proteins (S20, S21 and S24) when compared to large subunit r-proteins (L3, L9, L30 and L38). This correlates with a relative decrease in 18S rRNA with respect to 28S rRNA. PMID: 19454283
    43. Specific alleles at predicted transcription factor binding sites may alter the expression of RPS19, modify an important interaction between transcription factors with overlapping TFBS or remove an important stimulus for hematopoiesis PMID: 19587786
    44. Primary fibroblasts from Diamond-Blackfan anemia patients with truncating mutations in RPS19 or in RPS24 have a marked reduction in proliferative capacity. PMID: 19689926

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  • 相关疾病：
    Diamond-Blackfan anemia 1 (DBA1)
  • 亚细胞定位：
    Nucleus. Note=Located more specifically in the nucleoli.
  • 蛋白家族：
    Eukaryotic ribosomal protein eS19 family
  • 组织特异性：
    Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.
  • 数据库链接：

    HGNC: 10402

    OMIM: 105650

    KEGG: hsa:6223

    STRING: 9606.ENSP00000470004

    UniGene: Hs.438429