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  4. Recombinant Drosophila melanogaster Stromal interaction molecule homolog (Stim), partial

Recombinant Drosophila melanogaster Stromal interaction molecule homolog (Stim), partial

  • 货号：
    CSB-YP306602DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP306602DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP306602DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP306602DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP306602DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Stim
  • Uniprot No.：
  • 别名：
    Stim; CG9126; Stromal interaction molecule homolog
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores.
  • 基因功能参考文献：
    1. These data identify an essential role for STIM in larval dopaminergic cells. PMID: 28131984
    2. after depletion of Ca(2+) stores in Drosophila, translocation of the IP3R to Endoplasmic reticulum-plasma-membrane junctions facilitates the coupling of STIM to Orai that leads to activation of Store-operated Ca(2+) entry. PMID: 27591258
    3. Data indicate that STIM functions as sensors of Ca2+ stored in the endoplasmic reticulum (ER) lumen and translocate into ER-PM (plasma membrane) junctions to tether and activate Orai channels when ER Ca2+ concentration decreases. PMID: 23512988
    4. Induced STIM1 translocation to the plasma membrane promotes intestinal epithelial cell migration after wounding by enhancing TRPC1-mediated Ca2+ signaling and provide new insight into the mechanism of intestinal epithelial restitution. PMID: 20631248
    5. proposal that STIM1 functions as the missing link between Ca2+ store depletion and store-operated calcium influx, serving as a Ca2+ sensor that translocates upon store depletion to the plasma membrane to activate CRAC channels PMID: 16208375
    6. Interaction with the C terminus of Stim thus induces Orai dimers to dimerize, forming tetramers that constitute the Ca(2+)-selective pore. PMID: 18820677
    7. dSTIM regulates growth and patterning of imaginal discs and indicate potential interactions with the Notch and Wingless signaling pathways. PMID: 18950512

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 数据库链接：

    KEGG: dme:Dmel_CG9126

    STRING: 7227.FBpp0073955

    UniGene: Dm.172