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  4. Recombinant Drosophila melanogaster Protein escargot (esg)

Recombinant Drosophila melanogaster Protein escargot (esg)

  • 中文名称：
    黑腹果蝇esg重组蛋白
  • 货号：
    CSB-YP326585DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇esg重组蛋白
  • 货号：
    CSB-EP326585DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇esg重组蛋白
  • 货号：
    CSB-EP326585DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇esg重组蛋白
  • 货号：
    CSB-BP326585DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇esg重组蛋白
  • 货号：
    CSB-MP326585DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    esg
  • Uniprot No.：
  • 别名：
    esg; flg; CG3758Protein escargot; Protein fleabag
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-470
  • 氨基酸序列
    MHTVEDMLVE KNYSKCPLKK RPVNYQFEAP QNHSNTPNEP QDLCVKKMEI LEENPSEELI NVSDCCEDEG VDVDHTDDEH IEEEDEDVDV DVDSDPNQTQ AAALAAAAAV AAAAAASVVV PTPTYPKYPW NNFHMSPYTA EFYRTINQQG HQILPLRGDL IAPSSPSDSL GSLSPPPHHY LHGRASSVSP PMRSEIIHRP IGVRQHRFLP YPQMPGYPSL GGYTHTHHHH APISPAYSEN SYYSMRSMTP ESSCSSSLPE DLSLKHKNLN LNLNTSQPGE QAAAKTGDMS PETMPNASAK KDKNQPPRYQ CPDCQKSYST FSGLTKHQQF HCPAAEGNQV KKSFSCKDCD KTYVSLGALK MHIRTHTLPC KCNLCGKAFS RPWLLQGHIR THTGEKPFSC QHCHRAFADR SNLRAHLQTH SDIKKYSCTS CSKTFSRMSL LTKHSEGGCP GGSAGSSSSS ELNYAGYAEP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that can both stimulate and repress transcription. Binds to the consensus DNA sequence 5'-A/GCAGGTG-3'. Regulates cell motility and adhesion during tracheal morphogenesis by stimulating transcription of the DE-cadherin gene shg at branch tips, thereby promoting tracheal tube fusion. Maintains diploidy in imaginal cells by inhibiting the transcription of genes required for endoreplication. Required for development of the genital disk and acts as an intrinsic determinant of wing cell fate. The somatic protein is required for maintenance of male germ cells. Acts with other members of the snail protein family to control embryonic central nervous system development.
  • 基因功能参考文献：
    1. Esg controls specification of cell types in trachea and suppresses ERK signaling in fusion cells to control cells' differential migratory behavior. PMID: 27742749
    2. Escargot and Scratch regulate neural commitment by antagonizing Notch activity in Drosophila sensory organs PMID: 27471258
    3. CySCs mutant for esg are not maintained as stem cells, but remain capable of differentiating normally along the cyst cell lineage. In contrast, esg mutant CySCs that give rise to a closely related lineage, the apical hub cells, cannot maintain hub cell identity. this dual regulatory role is due to simultaneous control by Esg of overlapping genetic programs. Similar results were obtained with intestinal stem cells. PMID: 27077690
    4. Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch. PMID: 26077448
    5. Cell type-specific transcriptome analysis combined with Dam-ID binding studies identified Esg as a major repressor of differentiation genes in stem and progenitor cells. PMID: 25298397
    6. s demonstrate that Esg plays a pivotal role in intestinal homeostasis, maintaining the stem cell pool while influencing fate decisions through modulation of Notch activity. PMID: 25433031
    7. Escargot protein as an essential factor is required in hub cells for maintaining niche integrity by blocking conversion of hub cells to the cyst cell lineage. PMID: 24794442
    8. Escargot directly interact with Daughtherless and its mammalian homologue HEB and eliminate them through siah-1 mediated protein degradation. PMID: 20647756
    9. role as an enhancer trap that monitors male-specific gene expression in germ cells PMID: 11902678
    10. snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu. PMID: 15110709
    11. esg must be ectopically expressed during nervous system development to reduce seizure susceptibility in adult drosophila. PMID: 15654097

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Snail C2H2-type zinc-finger protein family
  • 组织特异性：
    Expression is complex and dynamic. In early embryogenesis, expression begins on the dorsal side of the embryo. Expressed in a pattern of longitudinal stripes early in germband elongation. Later in embryogenesis, expression is in cells that correspond to t
  • 数据库链接：

    KEGG: dme:Dmel_CG3758

    STRING: 7227.FBpp0080293

    UniGene: Dm.4764