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  4. Recombinant Drosophila melanogaster Drosomycin (Drs)

Recombinant Drosophila melanogaster Drosomycin (Drs)

  • 中文名称：
    黑腹果蝇Drs重组蛋白
  • 货号：
    CSB-YP331379DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Drs重组蛋白
  • 货号：
    CSB-EP331379DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Drs重组蛋白
  • 货号：
    CSB-EP331379DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Drs重组蛋白
  • 货号：
    CSB-BP331379DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Drs重组蛋白
  • 货号：
    CSB-MP331379DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Drs
  • Uniprot No.：
  • 别名：
    Drs; CRP; CG10810Drosomycin; Cysteine-rich peptide
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-70
  • 氨基酸序列
    DCLS GRYKGPCAVW DNETCRRVCK EEGRSSGHCS PSLKCWCEGC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Possesses antifungal activity and is active against a relatively broad spectrum of filamentous fungi. It inhibits spore germination at high concentrations and at low concentrations delays growth of hyphae which subsequently exhibit abnormal morphology. Spz C-106 in the hemolymph controls expression of the antifungal peptide by acting as a ligand of Tl and inducing an intracellular signaling pathway. Part of a psh-dependent Toll pathway, which may function in activating the systematic immune response in response to localized melanization of the tracheal system.
  • 基因功能参考文献：
    1. in this study drosomycin is identified as the target of miR-964 PMID: 28823799
    2. In 14-3-3epsilon mutants, there was a reduced release of the anti-microbial peptide Drosomycin into the haemolymph PMID: 21670199
    3. identified five cationic residues (R6, K8, R20, R21 and K38) whose alterations significantly affected the antifungal activity PMID: 20420852
    4. Expression of the AMP gene drosomycin (a Toll target) was blocked when expression of the Toll ligand Spatzle was knocked down in haemocytes. PMID: 19934223
    5. Similarity in sequence, structure and biological activity suggests that drosomycin and some defensin molecules from plants and fungi could originate from a common ancestor. PMID: 19754735

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Synthesized in the fat body and is secreted into the blood. In hemolymph 6 hours after immune challenge, levels of expression increase for first 24 hours and persist for the following three weeks. In larvae, expressed in the visceral branches and posterio
  • 数据库链接：

    KEGG: dme:Dmel_CG10810

    STRING: 7227.FBpp0072935

    UniGene: Dm.14479