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  4. Recombinant Drosophila melanogaster Cdc42 homolog (Cdc42)

Recombinant Drosophila melanogaster Cdc42 homolog (Cdc42)

  • 货号：
    CSB-YP334771DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP334771DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP334771DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP334771DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP334771DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cdc42; CG12530Cdc42 homolog; EC 3.6.5.2
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-188
  • 氨基酸序列
    MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCQKTPF LLVGTQIDLR DENSTLEKLA KNKQKPITME QGEKLAKELK AVKYVECSAL TQKGLKNVFD EAILAALEPP EPTKKRKC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt and Frl, regulates photoreceptor cell morphogenesis. Together with Frl, has a role in the neuronal development of mushroom bodies.
  • 基因功能参考文献：
    1. Cdc42 controls protrusion formation in a cell non-autonomous manner. PMID: 28143705
    2. Cdc42 regulates binding of Crumbs protein to the Par-6 CRIB-PDZ module. PMID: 26894406
    3. We propose that the guanine nucleotide exchange factor GEFmeso is involved in a developmental process that requires the synergistic action of CDC42 and Rac1 during Drosophila development PMID: 25753922
    4. A proof-of-principle experiment in which the Cdc42 GTPase associates with its alleged partner WASp within neurons during the time and space that coincide with the newly developing CNS. PMID: 24586421
    5. The distinct buttoning mechanism we propose for dorsal vessel closure is elaborated through signaling pathways regulating Cdc42 activity in this cell type. PMID: 24949939
    6. Zir is necessary to activate the Rho-family GTPases Rac2 and Cdc42 during the Drosophila cellular immune response. PMID: 22634526
    7. Wsp activity in within the fly testis is mediated by the small GTPase Cdc42. PMID: 21652648
    8. Drosophila Rich (dRich), a conserved Cdc42-selective guanosine triphosphatase-activating protein (GAP), inhibits the Cdc42-Wsp pathway to stimulate postsynaptic Gbb release PMID: 21041451
    9. Recruitment of Cdc42 and Rac1 to the sites of filopodium and lamellipodium formation is Rab35 dependent and occurs by way of microtubule tracks. PMID: 20065041
    10. ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster. PMID: 11997505
    11. Cdc42 is a regulator for multiple aspects of dendritic development in Drosophila PMID: 12716918
    12. Both Rac1 and Cdc42 activation induced large growth cones and long filopodia, but Cdc42 did so more efficiently than Rac1. Cdc42 is specifically involved in the regulation of actin filaments in growth cones. PMID: 14750960
    13. Rho GTPases may have partially overlapping functions during planar cell polarity generation PMID: 17616927
    14. Synaptic growth activated by growth factor signaling is controlled at an endosomal compartment via coordinated Nwk and Cdc42-dependent actin assembly. PMID: 18701694
    15. The Par complex acts as an effector for Cdc42 in controlling the endocytosis of apical proteins. PMID: 19064670
    16. we propose that Ephexin/Cdc42 couples synaptic Eph signaling to the modulation of presynaptic CaV2.1 channels PMID: 19249276
    17. study showed Cdc42 remains inactive in embryos during the 1st two-thirds of embryogenesis; in the central nervous system where Cdc42 activity first becomes upregulated, individual neurons display patterns restricted to specific subcellular compartments PMID: 19498173
    18. Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension. PMID: 19805632

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  • 亚细胞定位：
    Cell junction, adherens junction. Cell membrane; Lipid-anchor. Note=Adherens junctions of developing photoreceptor cells.
  • 蛋白家族：
    Small GTPase superfamily, Rho family, CDC42 subfamily
  • 数据库链接：

    KEGG: dme:Dmel_CG12530

    STRING: 7227.FBpp0301153

    UniGene: Dm.2867