Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Dog Caveolin-1 (CAV1)

Recombinant Dog Caveolin-1 (CAV1)

  • 货号：
    CSB-YP004571DO
  • 规格：
    ￥2616
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    CAV1; CAVCaveolin-1; Vesicular integral-membrane protein VIP21
  • 种属：
    Canis lupus familiaris (Dog) (Canis familiaris)
  • 蛋白长度：
    Full Length
  • 来源：
    Yeast
  • 分子量：
    22.6kDa
  • 表达区域：
    1-178a
  • 氨基酸序列
    MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMAEEMSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPFFEAVGKIFSNIRINMQKET
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.
  • 基因功能参考文献：
    1. results demonstrate that knockdown of EPLIN or Cav-1 substantially suppresses apical extrusion of transformed cells, implying that the expression of these molecules is required for the elimination of newly emerging transformed cells from the epithelium. PMID: 25609711
    2. Early intervertebral disc degeneration involves down-regulation of Caveolin-1 expression PMID: 23360510
    3. To better understand the role of caveolin-1 in bone homeostasis and response to beta-TCP scaffold, beta-TCP was implanted into mandible defects, and gene expression profiles were examined focused on the molecular components involved in caveolin-1 regulation. PMID: 23401359
    4. Malignant mammary cells showed a loss of Cav-1 expression. Our findings indicate that Cav-1 is a potential prognostic marker for canine mammary tumors. PMID: 22370882
    5. Alcohol promotes the myocardial oxidative stress and fibrosis through an elevated expression of PYK2 and a lowered expression of caveolin-1. PMID: 21914371
    6. Diminished function of human BCRP transfected into MDCK cells after canine Cav1 knockdown is likely mediated by alterations in protein-protein interactions and suggests a positive regulation of BCRP function by CAV1. PMID: 20936466
    7. these is a strong correlation between Cav-1-positive breast carcinomas and shorter overall survival in dogs. PMID: 20153868
    8. RNAi-mediated Cav-1 knock-down results in a decrease in virus titre in infected Madin-Darby canine kidney cells. PMID: 20504340
    9. These findings link increased expression of Cav-1 to neoplastic transformation and suggest that Cav-1 expression is associated with more malignant canine mammary tumours and their vascular invasion and regional lymph node metastasis. PMID: 20153867
    10. caveolin-1 does not play a major role in lipid raft-mediated biosynthetic membrane trafficking PMID: 16260622
    11. EGF-based signaling cascades phosphorylate Cav1 and have roles in caveolae assembly PMID: 16332692
    12. These data suggest that, upon stimulation, Galpha(q)(GTP) switches from having strong interactions with Gbetagamma to Cav1, thereby releasing Gbetagamma. PMID: 18397999

    显示更多

    收起更多

  • 亚细胞定位：
    Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Caveolin family
  • 数据库链接：

    KEGG: cfa:403980

    STRING: 9615.ENSCAFP00000005060

    UniGene: Cfa.3850