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  4. Recombinant Danio rerio Protein cereblon (crbn)

Recombinant Danio rerio Protein cereblon (crbn)

  • 货号：
    CSB-YP734655DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP734655DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP734655DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP734655DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP734655DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    crbn; zgc:92404Protein cereblon; zcrbn
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-431
  • 氨基酸序列
    MGNQLQLLPE NEEEEEDDME TEDRDGEDVE KPSIINFDTS LPTSHAYLGS DMEEFHGRTL HDEDSVQNLP VLPHVALILI PGQTLPLQLF RPQEVSMFRN LVSQDRTFAV LAHSPDPSGT ETKAEFGTTA EIYAFREEQE YGIETVKIKA VGRQRFRVHD IRTQADGIRQ AKVQILPERI LPDPLCALQF LPRLHTHSPQ TKHTQTTPPQ KRCSQNYRQK KLHCASMTSW PPWVYSLYDS KTLMSRVKKQ LHEWDENLKD ESLPTNPTDF SYRVAACLPI DDALRLQLLK IGSAIQRLRC ELDIMDRCTS LCCKQCQDTE ITSKNEIFSL SLYGPMAAYV NPHGYVHETL TVYKASNLNL IGRPSTLHSW FPGYAWTIAQ CRTCSSHMGW KFSAVKKDLS PPRFWGLTRS ALLPTIPQGE EGVEGSRLLC L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CRBN family
  • 组织特异性：
    Highly expressed in brain, head, vasculature otic vesicles and developing pectoral fins.
  • 数据库链接：

    KEGG: dre:445491

    STRING: 7955.ENSDARP00000062723

    UniGene: Dr.84847