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  4. Recombinant Danio rerio Protein Wnt-4a (wnt4a)

Recombinant Danio rerio Protein Wnt-4a (wnt4a)

  • 中文名称：
    斑马鱼wnt4a重组蛋白
  • 货号：
    CSB-YP343319DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斑马鱼wnt4a重组蛋白
  • 货号：
    CSB-EP343319DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斑马鱼wnt4a重组蛋白
  • 货号：
    CSB-EP343319DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斑马鱼wnt4a重组蛋白
  • 货号：
    CSB-BP343319DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斑马鱼wnt4a重组蛋白
  • 货号：
    CSB-MP343319DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    wnt4a
  • Uniprot No.：
  • 别名：
    wnt4a; wnt-4; wnt4; Protein Wnt-4a
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-352
  • 氨基酸序列
    SNWLYLAK LSSVGSISDE ETCEKLRGLI QRQVQICKRN VEVMDAVRRG AQLAIDECQY QFRNRRWNCS TLESVPVFGK VVTQGTREAA FVYAISAASV AFAVTRACSS GELDKCGCDR NVHGVSPEGF QWSGCSDNIA YGVAFSQSFV DIRERSKGQS SNRALMNLHN NEAGRKAILN HMRVECKCHG VSGSCEVKTC WKAMPPFRKV GNVIKEKFDG ATEVELRKVG TTKVLVPRNS QFKPHTDEDL VYLDPSPDFC EHDPRTPGIM GTAGRFCNKT SKAIDGCELM CCGRGFHTEE VEVVDRCSCK FHWCCYVKCK QCRKMVEMHT CR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand for members of the frizzled family of seven transmembrane receptors. Plays an important role in embryonic development.
  • 基因功能参考文献：
    1. Fox1 activation of Wnt4a in the ectoderm signals the epithelial stabilization of pouch-forming cells during late-stage of pouch morphogenesis. PMID: 29932895
    2. Data show that in vivo, wnt11r and wnt4a initiate MuSK translocation from muscle membranes to recycling endosomes and that this transition is crucial for AChR accumulation at future synaptic sites. PMID: 22318632
    3. Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt signaling inhibitor, Dkk, and induced expression of the Wnt ligand, Wnt4a. PMID: 21911394
    4. Findings provide the first convincing line of evidence that EAF and Wnt4 form an auto-regulatory negative feedback loop in vivo. PMID: 20161747
    5. three Wnt noncanonical ligands wnt4a, silberblick/wnt11, and wnt11-related regulate the process of convergence of endoderm and organ precursors toward the embryonic midline by acting in a largely redundant way PMID: 15630025

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Wnt family
  • 组织特异性：
    Caudal forebrain and neural keel, the floor plate, the gill slit and the developing pronephros.
  • 数据库链接：

    KEGG: dre:30123

    STRING: 7955.ENSDARP00000095904

    UniGene: Dr.385