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  4. Recombinant Danio rerio Neuroglobin (ngb)

Recombinant Danio rerio Neuroglobin (ngb)

  • 货号：
    CSB-YP015776DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015776DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015776DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015776DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015776DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ngb
  • Uniprot No.：
  • 别名：
    ngb; si:ch211-233n24.2; Neuroglobin
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-159
  • 氨基酸序列
    MEKLSEKDKG LIRDSWESLG KNKVPHGIVL FTRLFELDPA LLTLFSYSTN CGDAPECLSS PEFLEHVTKV MLVIDAAVSH LDDLHTLEDF LLNLGRKHQA VGVNTQSFAL VGESLLYMLQ SSLGPAYTTS LRQAWLTMYS IVVSAMTRGW AKNGEHKSN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Capable of penetrating cell membranes.
  • 基因功能参考文献：
    1. The zebrafish Neuroglobin can catalyze the reduction of nitrite to nitric oxide with a broad range of reaction rate constants. PMID: 26721561
    2. Data show that the neuroglobin (Ngb) protein was upregulated in the amacrine cells after optic nerve injury. PMID: 26427474
    3. Chimeric Myoglobin has a cell-membrane-penetrating activity similar to zebrafish Ngb. PMID: 21304818
    4. Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin-like function of this protein in facilitated oxygen diffusion PMID: 15140880
    5. both zebrafish and chimeric ZHHH Ngb can penetrate cell membranes in the absence of Chariot PMID: 18416560

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  • 亚细胞定位：
    Perikaryon. Cytoplasm.
  • 蛋白家族：
    Globin family
  • 组织特异性：
    Detected in brain, eye and gill, but not in muscle and blood (at protein level). Particularly high expression in the periventral zone of tectum opticum, with significant expression detected in white matter, preglomerular nucleus, posterior tubular nucleus
  • 数据库链接：

    KEGG: dre:100000711

    STRING: 7955.ENSDARP00000069992

    UniGene: Dr.82642