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  4. Recombinant Danio rerio Neurogenin-1 (neurog1)

Recombinant Danio rerio Neurogenin-1 (neurog1)

  • 货号：
    CSB-YP015730DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015730DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015730DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015730DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015730DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    neurog1; neurod3; ngn1; ngr1; Neurogenin-1; NGN-1; Neurogenic differentiation factor 3; NeuroD3; Neurogenin-related protein 1
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-208
  • 氨基酸序列
    MEIVYSDMET SSCDYSFSHT DDEDSRSSLH PASPASSCGK PPASPAGLQQ KKRRRGRARN ETTVHVVKKN RRLKANDRER NRMHNLNDAL DALRSVLPAF PDDTKLTKIE TLRFAHNYIW ALSETIRIAD QKQGKSRDGP LLLPGLSCMA DAPSPGSDSC SWPSGASSSS SSPSYCNSDP GSPAAMDDFG YLQTDVVYSY RNFVPSIY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator. Activates transcription by binding to the E box-containing promoter. Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specification of dopaminergic progenitor cells. May be involved in maintaining rhombomere boundaries in the hindbrain.
  • 基因功能参考文献：
    1. zebrafish Dmrta2 controls neurogenin1 expression by repressing her6 in the posterior-dorsal telencephalon PMID: 22023386
    2. Id3 was expressed specifically in a subset of DA neurons in the ventral diencephalon, with co-expression of neurogenin1 (Ngn1). PMID: 21061380
    3. neurogenin1 (ngn1) is required for the development of all zebrafish cranial ganglia PMID: 12413897
    4. regulatory sequences with temporally and spatially distinct activities control ngn1 expression in primary neurons of the zebrafish embryo. These regions are highly similar to 5' sequences in the mouse and human ngn1 gene PMID: 12559493
    5. ash1a and ngn1 function in parallel redundant pathways to regulate neurogenesis downstream of flh PMID: 12702659
    6. In zebrafish, TCDD reduces embryonic brain development due to decreased expression of neurogenin and sonic hedgehog. PMID: 14600291
    7. Data suggest that Her5 acts as a prepattern gene to suppress both neurogenin1 (ngn1) and coe2 mRNA expression and to prevent neurogenesis in the anlage of the midbrain/hindbrain boundary in the zebrafish neural plate. PMID: 15056616
    8. the upstream region of zebrafish ngn1 is capable of faithfully recapitulating endogenous expression in the zebrafish and mouse telencephalon PMID: 15496438
    9. global 'Him+Her5' activity inhibits ngn1 expression in a dose-dependent manner and through different sensitivity thresholds along the medio-lateral axis of the neural plate PMID: 15590746
    10. identify Ngn1 as a determinant of brain dopaminergic neurons and provide insights into how forebrain embryonic zinc-finger like regulates the development of these clinically important neuronal types PMID: 16549779
    11. the emergence of two atonal homologs, ath1 and ngn1, allowed the cellular segregation of mechanoreception and signal transmission that were originally performed by a single cell type as found in insects PMID: 16678150
    12. Neurog1 acts as the key factor in this lineage to direct the formation of sensory neurons in zebrafisn. PMID: 19020048

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Embryonic nervous system. Expressed transiently in neurogenic placodes prior to delamination and formation of cranial ganglia. Expressed early (6-somite stage) in Rohon-Beard spinal sensory neurons and later in neural crest-derived dorsal root ganglion ne
  • 数据库链接：

    KEGG: dre:30239

    STRING: 7955.ENSDARP00000073024

    UniGene: Dr.75780