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  4. Recombinant Chicken Transcription factor E2F1 (E2F1)

Recombinant Chicken Transcription factor E2F1 (E2F1)

  • 货号：
    CSB-YP852673CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP852673CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP852673CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP852673CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP852673CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    E2F1Transcription factor E2F1; E2F-1
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-403
  • 氨基酸序列
    MATAGGAAGL AALLGGASPH LLIVSASEEP AGGCRPDADL LLFATPQPSR PGPAPRRPAL GRPPVKRKLN LETDHQYIAE SLPAARGRAR IPGRGAKSPG EKSRYETSLN LTTKRFLELL SQSPDGVVDL NWAAEVLKVQ KRRIYDITNV LEGIQLITKK SKNNIQWLGS QVAAGASSRQ RLLEKELRDL QAAERQLDDL IQTCTVRLRL LTEDPSNQHA AYVTCQDLRS IVDPSEQMVM VIKAPPETQL QVSDPGEAFQ VSVRSTQGPI DVFLCPEDSS GVCSPVKSPF KAPAEELSPG SSQQRASPLL HSAQDVNMLL PEALLPGTAL PTKCPTEDVS LSPLASMDTL LEHGKDDFPG FLADEFIALS PPQPQDYHFG LEEGEGISEL FDCDFGDFTH LDF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Positively regulates transcription of RRP1B.
  • 基因功能参考文献：
    1. E2F1 can bind directly to promoters of the miR-17~92 and miR-106a~363 clusters and activate their transcription, and E2F1 protein expression is correlated with the expression of pri-miR-17~92 and pri-miR-106a~363 during myoblast differentiation. PMID: 27282946
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    E2F/DP family
  • 数据库链接：

    KEGG: gga:396142

    STRING: 9031.ENSGALP00000004806

    UniGene: Gga.3213