Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Chicken Protein Wnt-3a (WNT3A)

Recombinant Chicken Protein Wnt-3a (WNT3A)

  • 货号：
    CSB-YP641688CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP641688CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP641688CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP641688CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP641688CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    WNT3AProtein Wnt-3a
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-352
  • 氨基酸序列
    SY PIWWSLAIGH QYSSLGTQPI LCGSIPGLVP KQLRFCRNYV EIMPSVAEGV KIGIQECQHQ FRGRRWNCTT VNDSLAIFGP VLDKATRESA FVHAIASAGV AFAVTRSCAE GSATICGCDT RHKGSPGEGW KWGGCSEDVE FGSMVSREFA DARENRPDAR SAMNRHNNEA GRTSIIELMH LKCKCHGLSG SCEVKTCWWS QPDFRVIGDY LKDKYDSASE MVVEKHRESR GWVETLRPKY NFFKAPTEKD LVYYENSPNF CEPNPETGSF GTRDRICNVT SHGIDGCDLL CCGRGHNTRT EKRKEKCHCI FHWCCYVRCQ ECIRVYDVHT CK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube.
  • 基因功能参考文献：
    1. also enhances FGF8 activity while inhibiting BMP5 and WNT3a signaling PMID: 22898776
    2. These results identify Wif-1 as a novel extracellular Wnt modulator in cartilage biology. PMID: 19755491
    3. WNT3A up-regulates WNT/CTNNB1 signaling and regulates FGF signaling during embryonic limb development PMID: 11290326
    4. These results provide the framework for understanding how Sfrps function to regulate Wnt-3a activity in developing embryos and in cancer. PMID: 16425220
    5. there are temporal-specific responses and differential sensitivities to lithium/Wnt-3A exposure during early heart development PMID: 16804895
    6. Alternatively spliced Wnt3a variant 2 transcript is an active form of chick Wnt3a that regulates formation of the apical ectodermal ridge. PMID: 17488271
    7. Wnt-3a is involved in the myogenic induction observed after cholesterol depletion. PMID: 18037380
    8. Cardiac progenitors migrate in highly directed trajectories, which can be controlled by Wnt3a. Ectopic Wnt3a altered movement trajectories and caused cardia bifida. This was rescued by electroporation of DN-Wnt3a into prospective cardiac cells. PMID: 18256196
    9. Studied Wnt3a expression patterns in chick embryo nervous system PMID: 7577679

    显示更多

    收起更多

  • 亚细胞定位：
    [Isoform 1]: Secreted, extracellular space, extracellular matrix. Secreted.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Wnt family
  • 组织特异性：
    Expressed in cornea. Isoform 1 is expressed in the primitive streak, dorsal neural tube, proximal otic vesicle, the apical ectodermal ridge and the epithelium of feather buds.
  • 数据库链接：

    KEGG: gga:395396

    STRING: 9031.ENSGALP00000030667

    UniGene: Gga.209