Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Chicken Pituitary homeobox 2 (PITX2)

Recombinant Chicken Pituitary homeobox 2 (PITX2)

  • 货号：
    CSB-YP018043CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP018043CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP018043CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP018043CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP018043CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    PITX2; PTX2; Pituitary homeobox 2; Homeobox protein PITX2; cPITX2; Paired-like homeodomain transcription factor 2
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-333
  • 氨基酸序列
    MSCMKDPLSL ERLGAGNNKL CSSSPSSSSS SSSCHHQQPA LAMATALAPG QARSSLEAAK HRLEVHTISD TSSPEAAEKE KSQQGKSEDA GPEDPSKKKR QRRQRTHFTS QQLQELEATF QRNRYPDMST REEIAVWTNL TEARVRVWFK NRRAKWRKRE RNQQAELCKN GFGPQFNGLM QPYDDMYPGY SYNNWAAKGL TSASLSTKSF PFFNSMNVNP LSSQSMFSPP NSISSMSMSS SMVPSAVTGV PGSGLNSLNN LNNLSNPSLN SAVPTPACPY APPTPPYVYR DTCNSSLASL RLKAKQHSSF GYASVQNPAS NLSACQYPVD RPV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis.
  • 基因功能参考文献：
    1. Pitx2 is essential for axis formation, and that it acts as a direct regulator of cVg1 expression by binding to enhancers within neighbouring genes. PMID: 25496870
    2. Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine PMID: 25482882
    3. Downregulation of PITX2 and LEF1 genes may interfere with ventral body wall formation in Cd chick model causing omphalocele by disrupting somite myogenesis. PMID: 21259014
    4. Wnt/Lef1 signaling regulates epaxial myogenesis via Pitx2. PMID: 19850024
    5. Data suggest that the Pitx2c N-terminal domain competes with endogenous Pitx2c for binding to a protein interaction partner that is required for the activation of genes that direct asymmetric morphogenesis along the left-right axis. PMID: 19681163
    6. Mechanism in females that actively promotes the underlying L-R asymmetry initiated by Pitx2 and the degeneration of the right gonad, and a mechanism in males that allows it to be ignored or overridden. PMID: 17959721
    7. Pitx2 is together with Pax6 expressed in the entire domain of the Rathke's pouch. PMID: 18647663
    8. Pitx2 activity directs asymmetrical gonad morphogenesis by controlling mitotic spindle orientation of the developing gonad cortex and how, by modulating cyclinD1 expression during asymmetric ovarian development PMID: 18678914

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family, Bicoid subfamily
  • 数据库链接：

    KEGG: gga:395862

    STRING: 9031.ENSGALP00000036884

    UniGene: Gga.3398